String Gas Cosmology and Structure Formation

It has recently been shown that a Hagedorn phase of string gas cosmology may provide a causal mechanism for generating a nearly scale-invariant spectrum of scalar metric fluctuations, without the need for an intervening period of de Sitter expansion. A distinctive signature of this structure formation scenario would be a slight blue tilt of the spectrum of gravitational waves. In this paper we give more details of the computations leading to these results.Comment: 12 pages, 3 figure

Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains

This work was supported by grants from Cancer Research UK (C434/A13067), the Wellcome Trust (098391/Z/12/Z) and Biotechnology and Biological Sciences Research Council (BB/J016004/1).The RING E3 ligase catalysed formation of lysine 63 linked ubiquitin chains by the Ube2V2–Ubc13 E2 complex is required for many important biological processes. Here we report the structure of the RING domain dimer of rat RNF4 in complex with a human Ubc13~Ub conjugate and Ube2V2. The structure has captured Ube2V2 bound to the acceptor (priming) ubiquitin with Lys63 in a position that could lead to attack on the linkage between the donor (second) ubiquitin and Ubc13 that is held in the active “folded back” conformation by the RING domain of RNF4. The interfaces identified in the structure were verified by in vitro ubiquitination assays of site directed mutants. This represents the first view of the synthesis of Lys63 linked ubiquitin chains in which both substrate ubiquitin and ubiquitin-loaded E2 are juxtaposed to allow E3 ligase mediated catalysis.PostprintPeer reviewe

The Cosmology of Massless String Modes

We consider the spacetime dynamics of a gas of closed strings in the context of General Relativity in a background of arbitrary spatial dimensions. Our motivation is primarily late time String Gas Cosmology, where such a spacetime picture has to emerge after the dilaton has stabilized. We find that after accounting for the thermodynamics of a gas of strings, only string modes which are massless at the self-dual radius are relevant, and that they lead to a dynamics which is qualitatively different from that induced by the modes usually considered in the literature. In the context of an ansatz with three large spatial dimensions and an arbitrary number of small extra dimensions, we obtain isotropic stabilization of these extra dimensions at the self-dual radius. This stabilization occurs for fixed dilaton, and is induced by the special string states we focus on. The three large dimensions undergo a regular Friedmann-Robertson-Walker expansion. We also show that this framework for late-time cosmology is consistent with observational bounds.Comment: 15 pages, no figures, references added (again

Moduli Stabilization in Brane Gas Cosmology with Superpotentials

In the context of brane gas cosmology in superstring theory, we show why it is impossible to simultaneously stabilize the dilaton and the radion with a general gas of strings (including massless modes) and D-branes. Although this requires invoking a different mechanism to stabilize these moduli fields, we find that the brane gas can still play a crucial role in the early universe in assisting moduli stabilization. We show that a modest energy density of specific types of brane gas can solve the overshoot problem that typically afflicts potentials arising from gaugino condensation.Comment: minor changes to match the journal versio

Using the stated preference method for the calculation of social discount rate

The aim of this paper is to build the stated preference method into the social discount rate methodology. The first part of the paper presents the results of a survey about stated time preferences through pair-choice decision situations for various topics and time horizons. It is assumed that stated time preferences differ from calculated time preferences and that the extent of stated rates depends on the time period, and on how much respondents are financially and emotionally involved in the transactions. A significant question remains: how can the gap between the calculation and the results of surveys be resolved, and how can the real time preferences of individuals be interpreted using a social time preference rate. The second part of the paper estimates the social time preference rate for Hungary using the results of the survey, while paying special attention to the pure time preference component. The results suggest that the current method of calculation of the pure time preference rate does not reflect the real attitudes of individuals towards future generations

Sequestered Dark Matter

We show that hidden-sector dark matter is a generic feature of the type IIB string theory landscape and that its lifetime may allow for a discovery through the observation of very energetic gamma-rays produced in the decay. Throats or, equivalently, conformally sequestered hidden sectors are common in flux compactifications and the energy deposited in these sectors can be calculated if the reheating temperature of the standard model sector is known. Assuming that throats with various warp factors are available in the compact manifold, we determine which throats maximize the late-time abundance of sequestered dark matter. For such throats, this abundance agrees with cosmological data if the standard model reheating temperature was 10^10 - 10^11 GeV. In two distinct scenarios, the mass of dark matter particles, i.e. the IR scale of the throat, is either around 10^5 GeV or around 10^10 GeV. The lifetime and the decay channels of our dark matter candidates depend crucially on the fact that the Klebanov-Strassler throat is supersymmetric. Furthermore, the details of supersymmetry breaking both in the throat and in the visible sector play an essential role. We identify a number of scenarios where this type of dark matter can be discovered via gamma-ray observations.Comment: 36 pages, 3 figures; v2: references added, v3: introduction extended and typos correcte

Reconnection of Non-Abelian Cosmic Strings

Cosmic strings in non-abelian gauge theories naturally gain a spectrum of massless, or light, excitations arising from their embedding in color and flavor space. This opens up the possibility that colliding strings miss each other in the internal space, reducing the probability of reconnection. We study the topology of the non-abelian vortex moduli space to determine the outcome of string collision. Surprisingly we find that the probability of classical reconnection in this system remains unity, with strings passing through each other only for finely tuned initial conditions. We proceed to show how this conclusion can be changed by symmetry breaking effects, or by quantum effects associated to fermionic zero modes, and present examples where the probability of reconnection in a U(N) gauge theory ranges from 1/N for low-energy collisions to one at higher energies.Comment: 25 Pages, 3 Figures. v2: comment added, reference adde

Dynamical decompactification from brane gases in eleven-dimensional supergravity

Brane gas cosmology provides a dynamical decompactification mechanism that could account for the number of spacetime dimensions we observe today. In this work we discuss this scenario taking into account the full bosonic sector of eleven-dimensional supergravity. We find new cosmological solutions that can dynamically explain the existence of three large spatial dimensions characterised by an universal asymptotic scaling behaviour and a large number of initially unwrapped dimensions. This type of solutions enlarge the possible initial conditions of the Universe in the Hagedorn phase and consequently can potentially increase the probability of dynamical decompactification from anisotropically wrapped backgrounds.Comment: 8 figures, JHEP3 styl

Looking Beyond Inflationary Cosmology

In spite of the phenomenological successes of the inflationary universe scenario, the current realizations of inflation making use of scalar fields lead to serious conceptual problems which are reviewed in this lecture. String theory may provide an avenue towards addressing these problems. One particular approach to combining string theory and cosmology is String Gas Cosmology. The basic principles of this approach are summarized.Comment: invited talk at "Theory Canada 1" (Univ. of British Columbia, Vancouver, Canada, June 2 - 4, 2005) (references updated

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer.

Drug combinations can improve angiostatic cancer treatment efficacy and enable the reduction of side effects and drug resistance. Combining drugs is non-trivial due to the high number of possibilities. We applied a feedback system control (FSC) technique with a population-based stochastic search algorithm to navigate through the large parametric space of nine angiostatic drugs at four concentrations to identify optimal low-dose drug combinations. This implied an iterative approach of in vitro testing of endothelial cell viability and algorithm-based analysis. The optimal synergistic drug combination, containing erlotinib, BEZ-235 and RAPTA-C, was reached in a small number of iterations. Final drug combinations showed enhanced endothelial cell specificity and synergistically inhibited proliferation (p < 0.001), but not migration of endothelial cells, and forced enhanced numbers of endothelial cells to undergo apoptosis (p < 0.01). Successful translation of this drug combination was achieved in two preclinical in vivo tumor models. Tumor growth was inhibited synergistically and significantly (p < 0.05 and p < 0.01, respectively) using reduced drug doses as compared to optimal single-drug concentrations. At the applied conditions, single-drug monotherapies had no or negligible activity in these models. We suggest that FSC can be used for rapid identification of effective, reduced dose, multi-drug combinations for the treatment of cancer and other diseases