Some thoughts on the role of the Reserve Banks

Monetary policy ; Monetary policy - United States

The federal budget's effects on intergenerational equity: undone or not undone?

Deficit financing ; Budget ; Income distribution

Lepton-number violation and right-handed neutrinos in Higgs-less effective theories

Following previous work, we identify a symmetry S_nat that generalizes the concept of custodial symmetry, keeping under control deviations from the Standard Model (SM). To realize S_nat linearly, the space of gauge fields has to be extended. Covariant constraints formulated in terms of spurions reduce S_nat back to SU(2)_L x U(1)_Y. This allows for a covariant introduction of explicit S_nat-breaking parameters. We assume that S_nat is at play in a theory of electroweak symmetry-breaking without a light Higgs particle. We describe some consequences of this assumption, using a non-decoupling effective theory in which the loop expansion procedure is based on both momentum and spurion power counting, as in Chiral Perturbation Theory. A hierarchy of lepton-number violating effects follows. Leading corrections to the SM are non-oblique. The effective theory includes stable light right-handed neutrinos, with an unbroken Z_2 symmetry forbidding neutrino Dirac masses. nu_R contribution to dark matter places bounds on their masses.Comment: Corresponds to published version: added subsection VI-D about order-of-magnitude estimate

Improvements and future challenges for the research infrastructure in the field “Measuring cognitive ability”

The assessment of cognitive abilities is critical in large-scale survey studies that aim at elucidating the longitudinal interplay between the individual’s cognitive potential and socio-economic variables. The format of such studies calls for assessment methods which can not only be administered economically but also display a high (psychometric) measurement quality. In consideration of recent theoretical and empirical advances in intelligence research, we recommend the implementation of tests drawing on working memory in large-scale survey studies. Working memory is a limited-capacity system for temporary storage and processing of information and currently discussed to be the cognitive key system underlying intellectual abilities. Four types of working memory tests are exemplarily described and critically evaluated with regard to their psychometric quality and the need for further evaluation.cognitive abilities, intelligence, knowledge, information processing, mental speed, working memory

The influence of shc proteins on the whole body energetic response to calorie restriction initiated in 3-month-old mice.

There is increasing evidence that Shc proteins play a role in energy metabolism, and we have previously reported that knockdown of Shc proteins influences the energetic response to acute (3 days) calorie restriction (CR) in 18-month-old mice. Whether Shc proteins play a role in the metabolic response to CR in younger mice has yet to be elucidated. Hence, we sought to determine the impact of 3 days and longer term (2 months) CR on energy expenditure (EE) and respiratory quotient (RQ) in 3 month-old Shc knockout (ShcKO) and wild-type (WT) mice. ShcKO mice decreased (P < 0.001) EE normalized for body weight (EEBW) by 3 days of CR, while no such change was observed in WT animals. However, both ShcKO and WT mice decreased (P < 0.001) EEBW at 2 months of CR and there were no differences in body weight between the ShcKO and WT mice at either 3 days or 2 months of CR. Consistent with increased fatty acid oxidation, only ShcKO mice maintained decreased (P < 0.001) 24 h RQ through 2 months of CR, suggesting that they were able to maintain increased fatty acid oxidation for a longer period of time than WT mice. These results indicate that Shc proteins may contribute to some of the acute energetic responses to CR

The influence of shc proteins and aging on whole body energy expenditure and substrate utilization in mice.

While it has been proposed that Shc family of adaptor proteins may influence aging by regulating insulin signaling and energy metabolism, the overall impact of Shc proteins on whole body energy metabolism has yet to be elucidated. Thus, the purpose of this study was to determine the influence of Shc proteins and aging on whole body energy metabolism in a mouse model under ambient conditions (22°C) and acute cold exposure (12°C for 24 hours). Using indirect respiration calorimetry, we investigated the impact of Shc proteins and aging on EE and substrate utilization (RQ) in p66 Shc-/- (ShcKO) and wild-type (WT) mice. Calorimetry measurements were completed in 3, 15, and 27 mo mice at 22°C and 12°C. At both temperatures and when analyzed across all age groups, ShcKO mice demonstrated lower 24 h total EE values than that of WT mice when EE data was expressed as either kJ per mouse, or adjusted by body weight or crude organ mass (ORGAN) (P≤0.01 for all). The ShcKO mice also had higher (P<0.05) fed state RQ values than WT animals at 22°C, consistent with an increase in glucose utilization. However, Shc proteins did not influence age-related changes in energy expenditure or RQ. Age had a significant impact on EE at 22°C, regardless of how EE data was expressed (P<0.05), demonstrating a pattern of increase in EE from age 3 to 15 mo, followed by a decrease in EE at 27 mo. These results indicate a decline in whole body EE with advanced age in mice, independent of changes in body weight (BW) or fat free mass (FFM). The results of this study indicate that both Shc proteins and aging should be considered as factors that influence energy expenditure in mice

State-of-the-art oriented review of CIRCUS

Mathematical procedures for CIRCUS, digital computer program which is based on built-in model library and is capable of time domain analysis of certain circuit