Slow-light enhanced optical detection in liquid-infiltrated photonic crystals

Slow-light enhanced optical detection in liquid-infiltrated photonic crystals is theoretically studied. Using a scattering-matrix approach and the Wigner-Smith delay time concept, we show that optical absorbance benefits both from slow-light phenomena as well as a high filling factor of the energy residing in the liquid. Utilizing strongly dispersive photonic crystal structures, we numerically demonstrate how liquid-infiltrated photonic crystals facilitate enhanced light-matter interactions, by potentially up to an order of magnitude. The proposed concept provides strong opportunities for improving existing miniaturized absorbance cells for optical detection in lab-on-a-chip systems.Comment: Paper accepted for the "Special Issue OWTNM 2007" edited by A. Lavrinenko and P. J. Robert

Experiences of family therapists working with parents after the forced removal of children: What can the contextual model tell us?

Parents whose children have been statutorily removed by child protection services are a vulnerable, hard-to-reach, and under-focused group. Their needs are numerous and complex. The Family Counselling Services in Norway are mandated to prioritize and provide emotional support services to this parent group. The study aimed to explore and understand the experiences and needs of family therapists through the lens of the Contextual Model (Wampold, 2015). A national sample of 21 therapists currently providing services to this parent group participated in the study. Data were collected using focus-group interviews. The main categories of the initial bond, the personal relationship, expectations, and therapy-specific ingredients provided a framework to assess what therapists already know and need in the future to provide services to the parent group. Therapists showed great awareness and strength in building a personal relationship with the client. However, they felt that sharpening their generalist knowledge with therapy-specific models would make them more effective therapists. The contextual model provided new concepts and vocabulary that can enrich research and clinical efforts and lift it to a broader audience.publishedVersio

Experiences of family therapists working with parents after the forced removal of children: What can the contextual model tell us?

This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.Parents whose children have been statutorily removed by child protection services are a vulnerable, hard-to-reach, and under-focused group. Their needs are numerous and complex. The Family Counselling Services in Norway are mandated to prioritize and provide emotional support services to this parent group. The study aimed to explore and understand the experiences and needs of family therapists through the lens of the Contextual Model (Wampold, 2015). A national sample of 21 therapists currently providing services to this parent group participated in the study. Data were collected using focus-group interviews. The main categories of the initial bond, the personal relationship, expectations, and therapy-specific ingredients provided a framework to assess what therapists already know and need in the future to provide services to the parent group. Therapists showed great awareness and strength in building a personal relationship with the client. However, they felt that sharpening their generalist knowledge with therapy-specific models would make them more effective therapists. The contextual model provided new concepts and vocabulary that can enrich research and clinical efforts and lift it to a broader audience.publishedVersio

On the Cost-of-Capital Rate under Incomplete Market Valuation

In this paper we discuss the concept of the cost-of-capital (CoC) rate for an insurance company as an equilibrium in the economic triangle of policyholders, shareholders, and the regulator. This provides a possible rationalization and an economic foundation for a quantity that is widely used in practice but whose value is typically neither technically nor economically well justified. We show how it can be well founded in such a triangular equilibrium. Under a simple one-period model and a valuation procedure of a two-price economy for illiquid assets we provide a corresponding economic-theoretical quantification for the CoC rate. The resulting rates are illustrated by a number of concrete numerical examples.ISSN:0022-4367ISSN:1539-697

Ship scale validation of CFD model of self-propelled ship

This paper presents a comparison of towing tank testing, ship scale computational fluid dynamics (CFD) simulations, sea trial measurements and in-service performance. The study includes extensive convergence tests and validation of both resistance, open-water and self-propulsion CFD simulations in both model and ship scale. The self-propulsion CFD simu- lations are conducted using a novel method. This method includes calculating the wave-making resistance separately, in order to reduce the computational cost. The results of the ship scale self-propulsion CFD show an average overestimation of delivered power of 2 % compared to the sea trial results, where the predicted delivered power using the towing tank approach shows an average overestimation of delivered power of 6 %. Both predic- tions are within the uncertainty of the speed trial measurements. The study shows that both the towing tank approach and ship scale CFD can make reasonable and similar estimations of the ship scale performance of a ship. Furthermore, we find that for the present ship, CFD is able to predict performance as accurately as towing tank procedures, indicating that ship scale CFD is a mature tool for use in future ship designs

Comparison of Fish Communities in Recently Constructed Side-Channel Chutes with the Main Stem Missouri River

Two United States Army Corp of Engineers- (USACE) funded projects were conducted from 2006 to 2008 along the Missouri River to monitor fish communities in recently constructed side-channel chutes and to monitor pallid sturgeon (Scaphirhynchus albus) and the associated fish assemblage in the main stem Missouri River. Data from both monitoring projects were compared to evaluate fish assemblages among four mitigated habitats (e.g., constructed side-channel chutes) and the main-stem Missouri River. Chutes had a greater overall number of species (n = 59) and higher species richness (Margalef’s index = 5.81), but richness was not different (F1, 4 = 0.23, P = 0.22) between chutes and the Missouri River main channel. Non-metric multidimensional scaling (NMDS) showed fish assemblages in side-channel chutes separated out from that of the main river, likely due to chutes having a few unique species that were not sampled in the main river. Relative abundance of native cyprinids that are important food items for pallid sturgeon [e.g., Shoal chub (Macrhybopsis hyostoma), sturgeon chub (M. gelida), silver chub (M. storeriana), sand shiner (Notropis ludibundus), and river shiner (N. blennius)] all showed a decline in the Missouri River during the period of study but were stable or increased in Upper Hamburg Chute (oldest constructed side-channel chute). Relative abundances of these species in the remaining chutes were variable over time with the exception of silver chub and river shiner, which declined across years in Kansas and Deroin side-channel chutes. Ongoing development of habitat complexity and diversity in these chutes may eventually lead to a more diverse and abundant fish assemblage

Can vitamin D3 supplementation prevent bone loss in persons with MS? A placebo-controlled trial

Multiple sclerosis (MS) is a possible cause of secondary osteoporosis. In this phase II trial we assessed whether a weekly dose of 20,000 IU vitamin D3 prevents bone loss in ambulatory persons with MS age 18–50 years. ClinicalTrials.gov ID NCT00785473. All patients managed at the University Hospital of North Norway who fulfilled the main inclusion criteria were invited to participate in this double-blinded trial. Participants were randomised to receive 20,000 IU vitamin D3 or placebo once a week and 500 mg calcium daily for 96 weeks. The primary outcome was the effect of the intervention on percentage change in bone mineral density (BMD) at the hip, the spine, and the ultradistal radius over the study period. Of 71 participants randomised, 68 completed. Mean serum 25-hydroxyvitamin D [25(OH)D] levels in the intervention group increased from 55 nmol/L at baseline to 123 nmol/L at week 96. After 96 weeks, percentage change in BMD did not differ between groups at any site. BMD decreased at the hip, by 1.4% in the placebo group (95% CI −2.3 to −0.4, SD 2.7, p = 0.006) and by 0.7% in the treatment group (−1.6 to 0.2, 2.7, p = 0.118), difference 0.7% (−1.9 to 0.7, p = 0.332). Findings were not altered by adjustment for sex or serum 25(OH)D. Supplementation with 20,000 IU vitamin D3 a week did not prevent bone loss in this small population. Larger studies are warranted to assess the effect of vitamin D on bone health in persons with MS

Plasma level of mannose-binding lectin is associated with the risk of recurrent pregnancy loss but not pregnancy outcome after the diagnosis

STUDY QUESTION: Are low or high plasma mannose-binding lectin (p-MBL) levels associated with recurrent pregnancy loss (RPL) and the reproductive and perinatal outcomes before and after RPL? SUMMARY ANSWER: The prevalence of low p-MBL levels was significantly higher in RPL patients, while high levels were significantly less prevalent. No association was found between p-MBL level and reproductive and perinatal outcomes before and after RPL. WHAT IS KNOWN ALREADY: Mannose-binding lectin (MBL) is an important component in the innate immune system. Low p-MBL levels have been associated with RPL, while the correlation with high levels has been poorly studied. Adverse perinatal outcomes are generally more frequent among RPL patients, but reports concerning the association between maternal p-MBL levels and perinatal outcomes, including birth weight (BW) and gestational age (GA), are conflicting. STUDY DESIGN, SIZE, DURATION: This study was a combined cross-sectional and cohort study of 267 RPL patients admitted to the RPL Center of Western Denmark between January 2016 and March 2020. RPL patients were followed until birth of a liveborn child or until end of follow-up, March 2021. A sample of 185 healthy female blood donors of reproductive age was used as a MBL reference group. PARTICIPANTS/MATERIALS, SETTING, METHODS: All RPL patients had ≥3 consecutive pregnancy losses, a regular menstrual cycle and no known significant chromosomal or uterine malformations. At the first consultation, routine blood samples including p-MBL measurement and detailed obstetrical and perinatal information were collected. p-MBL levels in RPL patients were compared to the MBL reference group. A logistic regression analysis adjusted for relevant confounders assessed the association between low p-MBL levels and an unsuccessful reproductive outcome in RPL patients in first pregnancy after admission. Perinatal outcomes before and after RPL were compared between RPL subgroups according to low (≤500 µg/l), intermediate (501–3000 µg/l) and high (>3000 µg/l) p-MBL levels. MAIN RESULTS AND THE ROLE OF CHANCE: Significantly more RPL patients had low p-MBL levels (prevalence proportion ratio (PPR): 1.79, 95% CI: 1.34–2.38) and fewer had high p-MBL levels (PPR: 0.56, 95% CI: 0.40–0.79) compared to the reference group, while the prevalence of intermediate p-MBL level was not different between the groups (PPR: 0.86, 95% CI: 0.69–1.08). In the prospective study, low p-MBL level was not a significant risk factor for a pregnancy loss in the first pregnancy after admission after adjustment for age, BMI and smoking. Neither before nor after the RPL diagnosis were maternal p-MBL levels significantly associated with BW or GA. LIMITATIONS, REASONS FOR CAUTION: Only 161 (60.3%) patients had given birth after RPL during the follow-up period, which limited the possibility to detect clear associations between p-MBL levels and perinatal outcomes after RPL. WIDER IMPLICATIONS OF THE FINDINGS: In agreement with several previous studies, low p-MBL levels are strongly associated with RPL, while this study for the first time documents that high levels may play a protective role, which suggests a causal relationship. We suggest that larger prospective studies evaluate the association between p-MBL levels and RPL prognosis. STUDY FUNDING/COMPETING INTEREST(S): No external funding was received. We acknowledge the Department of Obstetrics and Gynaecology at Aalborg University Hospital for financial support. U.S.K. has reported personal fees from Merck, consulting fees from IBSA Nordic, and a grant from Gedeon Richter, Merck and IBSA Nordic outside of the submitted work. TRIAL REGISTRATION NUMBER: ID from clinicaltrials.gov is NCT04017754

Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase

BACKGROUND: Citrullination catalysed by peptidylarginine deiminases (PADs) plays an important pathogenic role in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) and, possibly, several other inflammatory diseases. Non-physiological reducing agents such as dithiothreitol (DTT) are normally added to the reaction buffer when determining PAD activity in vitro. We investigated the ability of reduced glutathione (GSH), the most abundant intracellular small-molecule thiol in vivo, to activate PADs. METHODS: Activity of recombinant human (rh) PAD2 and PAD4, PADs contained in synovial fluid (SF) samples from RA patients and PADs released from phorbol 12-myristate 13-acetate (PMA)-stimulated cells was measured using an in-house PAD activity assay detecting citrullination of fibrinogen. RESULTS: No activity of rhPAD2, rhPAD4 or PADs within SF was observed without addition of an exogenous reducing agent. Activity of both recombinant and SF PAD was observed in the presence of 1 mM DTT or 10–15 mM GSH. Following stimulation with PMA, human isolated leucocytes, but not mononuclear cells, released enzymatically active PAD, the activity of which was abolished upon pre-incubation of the cells with the glutathione reductase inhibitor 2-AAPA. No PAD activity was observed in the corresponding supernatants, but addition of exogenous GSH restored activity. CONCLUSIONS: Catalytic activity of PAD requires reducing conditions. GSH meets this requirement at concentrations comparable with those found within cells. Active PAD, reduced by GSH, is released from PMA-stimulated granulocytes, but becomes inactivated in the extracellular space