7,739 research outputs found
Applications of Partial Supersymmetry
I examine quantum mechanical Hamiltonians with partial supersymmetry, and
explore two main applications. First, I analyze a theory with a logarithmic
spectrum, and show how to use partial supersymmetry to reveal the underlying
structure of this theory. This method reveals an intriguing equivalence between
two formulations of this theory, one of which is one-dimensional, and the other
of which is infinite-dimensional. Second, I demonstrate the use of partial
supersymmetry as a tool to obtain the asymptotic energy levels in
non-relativistic quantum mechanics in an exceptionally easy way. In the end, I
discuss possible extensions of this work, including the possible connections
between partial supersymmetry and renormalization group arguments.Comment: 11 pages, harvmac, no figures; typo corrected in identifying info on
title pag
A BPS Interpretation of Shape Invariance
We show that shape invariance appears when a quantum mechanical model is
invariant under a centrally extended superalgebra endowed with an additional
symmetry generator, which we dub the shift operator. The familiar mathematical
and physical results of shape invariance then arise from the BPS structure
associated with this shift operator. The shift operator also ensures that there
is a one-to-one correspondence between the energy levels of such a model and
the energies of the BPS-saturating states. These findings thus provide a more
comprehensive algebraic setting for understanding shape invariance.Comment: 15 pages, 2 figures, LaTe
Characterization of optical systems for the ALPS II experiment
ALPS II is a light shining through a wall style experiment that will use the
principle of resonant enhancement to boost the conversion and reconversion
probabilities of photons to relativistic WISPs. This will require the use of
long baseline low-loss optical cavities. Very high power build up factors in
the cavities must be achieved in order to reach the design sensitivity of ALPS
II. This necessitates a number of different sophisticated optical and control
systems to maintain the resonance and ensure maximal coupling between the laser
and the cavity. In this paper we report on the results of the characterization
of these optical systems with a 20 m cavity and discuss the results in the
context of ALPS II
Listening to the Enemy: Key Documents on the Role of Communications Intelligence in the War with Japan
Some Problems in Liquidating Personal Holding Companies
Ordinarily, distributions by a personal holding company qualify for the dividends paid deduction only if they are dividends under section 316. However, certain distributions in liquidation may also qualify. These liquidating distributions of a personal holding company are divided into two categories: (1) Distributions to the extent of earnings and profits for the taxable year (computed without regard to capital losses) made in complete liquidation of the corporation occurring within 24 months after the adoption of the plan of liquidation; and (2) distributions in liquidation properly chargeable to earnings and profits accumulated after February 28, 1913
Formation of a high quality two-dimensional electron gas on cleaved GaAs
We have succeeded in fabricating a two-dimensional electron gas (2DEG) on the cleaved (110) edge of a GaAs wafer by molecular beam epitaxy (MBE). A (100) wafer previously prepared by MBE growth is reinstalled in the MBE chamber so that an in situ cleave exposes a fresh (110) GaAs edge for further MBE overgrowth. A sequence of Si-doped AlGaAs layers completes the modulation-doped structure at the cleaved edge. Mobilities as high as 6.1Ă—10^5 cm^2/V s are measured in the 2DEG at the cleaved interface
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Selective cell death of latently HIV-infected CD4+ T cells mediated by autosis inducing nanopeptides.
Despite significant advances in the treatment of human immunodeficiency virus type-1 (HIV) infection, antiretroviral therapy only suppresses viral replication but is unable to eliminate infection. Thus, discontinuation of antiretrovirals results in viral reactivation and disease progression. A major reservoir of HIV latent infection resides in resting central memory CD4+ T cells (TCM) that escape clearance by current therapeutic regimens and will require novel strategies for elimination. Here, we evaluated the therapeutic potential of autophagy-inducing peptides, Tat-Beclin 1 and Tat-vFLIP-α2, which can induce a novel Na+/K+-ATPase dependent form of cell death (autosis), to kill latently HIV-infected TCM while preventing virologic rebound. In this study, we encapsulated autophagy inducing peptides into biodegradable lipid-coated hybrid PLGA (poly lactic-co-glycolic acid) nanoparticles for controlled intracellular delivery. A single dose of nanopeptides was found to eliminate latent HIV infection in an in vitro primary model of HIV latency and ex vivo using resting CD4+ T cells obtained from peripheral blood mononuclear cells of HIV-infected patients on antiretroviral with fully suppressed virus for greater than 12 months. Notably, increased LC3B lipidation, SQSTM1/p62 degradation and Na+/K+-ATPase activity characteristic of autosis, were detected in nanopeptide treated latently HIV-infected cells compared to untreated uninfected or infected cells. Nanopeptide-induced cell death could be reversed by knockdown of autophagy proteins, ATG5 and ATG7, and inhibition or knockdown of Na+/K+-ATPase. Importantly, viral rebound was not detected following the induction of the Na+/K+-ATPase dependent form of cell death induced by the Tat-Beclin 1 and Tat-vFLIP-α2 nanopeptides. These findings provide a novel strategy to eradicate HIV latently infected resting memory CD4+ T cells, the major reservoir of HIV latency, through the induction of Na+/K+-ATPase dependent autophagy, while preventing reactivation of virus and new infection of uninfected bystander cells
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