189 research outputs found
Intense high-quality medical proton beams via laser fields
During the past decade, the interaction of high-intensity lasers with solid
targets has attracted much interest, regarding its potential in accelerating
charged particles. In spite of tremendous progress in laser-plasma based
acceleration, it is still not clear which particle beam quality will be
accessible within the upcoming multi petawatt (1 PW = 10 W) laser
generation. Here, we show with simulations based on the coupled relativistic
equations of motion that protons stemming from laser-plasma processes can be
efficiently post-accelerated using crossed laser beams focused to spot radii of
a few laser wavelengths. We demonstrate that the crossed beams produce
monoenergetic accelerated protons with kinetic energies MeV, small
energy spreads ( 1) and high densities as required for hadron
cancer therapy. To our knowledge, this is the first scheme allowing for this
important application based on an all-optical set-up.Comment: 14 pages, 3 figures, 1 tabl
Feasibility of electron cyclotron autoresonance acceleration by a short terahertz pulse
A vacuum autoresonance accelerator scheme for electrons, which employs
terahertz radiation and currently available magnetic fields, is suggested.
Based on numerical simulations, parameter values, which could make the scheme
experimentally feasible, are identified and discussed
High-quality multi-GeV electron bunches via cyclotron autoresonance
Autoresonance laser acceleration of electrons is theoretically investigated
using circularly polarized focused Gaussian pulses. Many-particle simulations
demonstrate feasibility of creating over 10-GeV electron bunches of ultra-high
quality (relative energy spread of order 10^-4), suitable for fundamental
high-energy particle physics research. The laser peak intensities and axial
magnetic field strengths required are up to about 10^18 W/cm^2 (peak power ~10
PW) and 60 T, respectively. Gains exceeding 100 GeV are shown to be possible
when weakly focused pulses from a 200-PW laser facility are used
Direct High-Power Laser Acceleration of Ions for Medical Applications
Theoretical investigations show that linearly and radially polarized
multiterawatt and petawatt laser beams, focused to subwavelength waist radii,
can directly accelerate protons and carbon nuclei, over micron-size distances,
to the energies required for hadron cancer therapy. Ions accelerated by
radially polarized lasers have generally a more favorable energy spread than
those accelerated by linearly polarized lasers of the same intensity.Comment: 4 pages, 5 figure
Relativistic ionization-rescattering with tailored laser pulses
The interaction of relativistically strong tailored laser pulses with an
atomic system is considered. Due to a special tailoring of the laser pulse, the
suppression of the relativistic drift of the ionized electron and a dramatic
enhancement of the rescattering probability is shown to be achievable. The high
harmonic generation rate in the relativistic regime is calculated and shown to
be increased by several orders of magnitude compared to the case of
conventional laser pulses. The energies of the revisiting electron at the
atomic core can approach the MeV domain, thus rendering hard x-ray harmonics
and nuclear reactions with single atoms feasible
Coev-web: a web platform designed to simulate and evaluate coevolving positions along a phylogenetic tree.
BACKGROUND: Available methods to simulate nucleotide or amino acid data typically use Markov models to simulate each position independently. These approaches are not appropriate to assess the performance of combinatorial and probabilistic methods that look for coevolving positions in nucleotide or amino acid sequences.
RESULTS: We have developed a web-based platform that gives a user-friendly access to two phylogenetic-based methods implementing the Coev model: the evaluation of coevolving scores and the simulation of coevolving positions. We have also extended the capabilities of the Coev model to allow for the generalization of the alphabet used in the Markov model, which can now analyse both nucleotide and amino acid data sets. The simulation of coevolving positions is novel and builds upon the developments of the Coev model. It allows user to simulate pairs of dependent nucleotide or amino acid positions.
CONCLUSIONS: The main focus of our paper is the new simulation method we present for coevolving positions. The implementation of this method is embedded within the web platform Coev-web that is freely accessible at http://coev.vital-it.ch/, and was tested in most modern web browsers
Optimization strategies for fast detection of positive selection on phylogenetic trees.
MOTIVATION: The detection of positive selection is widely used to study gene and genome evolution, but its application remains limited by the high computational cost of existing implementations. We present a series of computational optimizations for more efficient estimation of the likelihood function on large-scale phylogenetic problems. We illustrate our approach using the branch-site model of codon evolution.
RESULTS: We introduce novel optimization techniques that substantially outperform both CodeML from the PAML package and our previously optimized sequential version SlimCodeML. These techniques can also be applied to other likelihood-based phylogeny software. Our implementation scales well for large numbers of codons and/or species. It can therefore analyse substantially larger datasets than CodeML. We evaluated FastCodeML on different platforms and measured average sequential speedups of FastCodeML (single-threaded) versus CodeML of up to 5.8, average speedups of FastCodeML (multi-threaded) versus CodeML on a single node (shared memory) of up to 36.9 for 12 CPU cores, and average speedups of the distributed FastCodeML versus CodeML of up to 170.9 on eight nodes (96 CPU cores in total).Availability and implementation: ftp://ftp.vital-it.ch/tools/FastCodeML/.
CONTACT: [email protected] or [email protected]
Microwave-induced control of Free Electron Laser radiation
The dynamical response of a relativistic bunch of electrons injected in a
planar magnetic undulator and interacting with a counterpropagating
electromagnetic wave is studied. We demonstrate a resonance condition for which
the free electron laser (FEL) dynamics is strongly influenced by the presence
of the external field. It opens up the possibility of control of short
wavelength FEL emission characteristics by changing the parameters of the
microwave field without requiring change in the undulator's geometry or
configuration. Numerical examples, assuming realistic parameter values
analogous to those of the TTF-FEL, currently under development at DESY, are
given for possible control of the amplitude or the polarization of the emitted
radiation.Comment: 14 pages, 5 figures, accepted for publication in Phys. Rev.
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