Rad62 protein functionally and physically associates with the Smc5/Smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast

Smc5 and Smc6 proteins form a heterodimeric SMC (structural maintenance of chromosome) protein complex like SMC1-SMC3 cohesin and SMC2-SMC4 condensin, and they associate with non-SMC proteins Nse1 and Nse2 stably and Rad60 transiently. This multiprotein complex plays an essential role in maintaining chromosome integrity and repairing DNA double strand breaks (DSBs). This study characterizes a Schizosaccharomyces pombe mutant rad62-1, which is hypersensitive to methyl methanesulfonate (MMS) and synthetically lethal with rad2 (a feature of recombination mutants). rad62-1 is hypersensitive to UV and gamma rays, epistatic with rhp51, and defective in repair of DSBs. rad62 is essential for viability and genetically interacts with rad60, smc6, and brc1. Rad62 protein physically associates with the Smc5-6 complex. rad62-1 is synthetically lethal with mutations in the genes promoting recovery from stalled replication, such as rqh1, srs2, and mus81, and those involved in nucleotide excision repair like rad13 and rad16. These results suggest that Rad62, like Rad60, in conjunction with the Smc5-6 complex, plays an essential role in maintaining chromosome integrity and recovery from stalled replication by recombination

Observation of Infrared and Radio Lines of Molecules toward GL2591 and Comparison to Physical and Chemical Models

We have observed rovibrational transitions of acetylene and HCN near 13 microns in absorption toward GL2591. We also observed rotational lines of CS, HCN, H2CO, and HCO+. The combined data are analyzed in terms of models with a cloud envelope with density gradients and discrete regions of hot, dense gas, probably near the infrared source. The abundance of HCN is enhanced by a factor of 400 in the gas producing the infrared absorption, in agreement with chemical models which involve depletion of molecules onto grains and subsequent sublimation when temperatures are raised.Comment: 34 pages, postscript with 14 postscript figure files, uuencoded compressed and tar'ed; unpacks self with csh. In case of problems, contact [email protected]

Investigation of infrared phonon modes in multiferroic single-crystal FeTe2_{2}O5_{5}Br

Reflection and transmission as a function of temperature (5--300 K) have been measured on single crystals of the multiferroic compound FeTe$_{2}$O$_{5}$Br utilizing light spanning the far infrared to the visible portions of the electromagnetic spectrum. The complex dielectric function and optical properties were obtained via Kramers-Kronig analysis and by fits to a Drude-Lortentz model. Analysis of the anisotropic excitation spectra via Drude-Lorentz fitting and lattice dynamical calculations have lead to the observation of all 52 IR-active modes predicted in the $ac$ plane and 43 or the 53 modes predicted along the b axis of the monoclinic cell. Assignments to groups (clusters) of phonons have been made and trends within them are discussed in light of our calculated displacement patterns.Comment: 9 pages, 7 figure

Pricing and hedging of Asian options: Quasi-explicit solutions via Malliavin calculus

We use Malliavin calculus and the Clark-Ocone formula to derive the hedging strategy of an arithmetic Asian Call option in general terms. Furthermore we derive an expression for the density of the integral over time of a geometric Brownian motion, which allows us to express hedging strategy and price of the Asian option as an analytic expression. Numerical computations which are based on this expression are provided

Asymptotically Friedmann self-similar scalar field solutions with potential

We investigate self-similar solutions which are asymptotic to the Friedmann universe at spatial infinity and contain a scalar field with potential. The potential is required to be exponential by self-similarity. It is found that there are two distinct one-parameter families of asymptotic solutions,one is asymptotic to the proper Friedmann universe, while the other is asymptotic to the quasi-Friedmann universe, i.e., the Friedmann universe with anomalous solid angle. The asymptotically proper Friedmann solution is possible only if the universe is accelerated or the potential is negative. If the potential is positive, the density perturbation in the asymptotically proper Friedmann solution rapidly falls off at spatial infinity, while the mass perturbation is compensated. In the asymptotically quasi-Friedmann solution, the density perturbation falls off only in proportion to the inverse square of the areal radius and the relative mass perturbation approaches a nonzero constant at spatial infinity. The present result shows that a necessary condition holds in order that a self-gravitating body grows self-similarly due to the constant accretion of quintessence in an accelerating universe.Comment: accepted for publication in Physical Review D, minor correction, typos correcte

Exact Dynamics of Multicomponent Bose-Einstein Condensates in Optical Lattices in One, Two and Three Dimensions

Numerous exact solutions to the nonlinear mean-field equations of motion are constructed for multicomponent Bose-Einstein condensates on one, two, and three dimensional optical lattices. We find both stationary and nonstationary solutions, which are given in closed form. Among these solutions are a vortex-anti-vortex array on the square optical lattice and modes in which two or more components slosh back and forth between neighboring potential wells. We obtain a variety of solutions for multicomponent condensates on the simple cubic lattice, including a solution in which one condensate is at rest and the other flows in a complex three-dimensional array of intersecting vortex lines. A number of physically important solutions are stable for a range of parameter values, as we show by direct numerical integration of the equations of motion.Comment: 22 pages, 9 figure

Stability criterion for self-similar solutions with a scalar field and those with a stiff fluid in general relativity

A stability criterion is derived in general relativity for self-similar solutions with a scalar field and those with a stiff fluid, which is a perfect fluid with the equation of state $P=\rho$. A wide class of self-similar solutions turn out to be unstable against kink mode perturbation. According to the criterion, the Evans-Coleman stiff-fluid solution is unstable and cannot be a critical solution for the spherical collapse of a stiff fluid if we allow sufficiently small discontinuity in the density gradient field in the initial data sets. The self-similar scalar-field solution, which was recently found numerically by Brady {\it et al.} (2002 {\it Class. Quantum. Grav.} {\bf 19} 6359), is also unstable. Both the flat Friedmann universe with a scalar field and that with a stiff fluid suffer from kink instability at the particle horizon scale.Comment: 15 pages, accepted for publication in Classical and Quantum Gravity, typos correcte

Binaural Interaction in the Nucleus Laminaris of the Barn Owl : A Quantitative Model

A quantitative, neuronal model is proposed for the computation of interaural time difference (ITD) in the auditory system of the barn owl. The model uses a general, probabilistic approach, and is composed of two stages, the characteristics of which are based on anatomical and physiological evidence. Excitatory inputs from both ears, phase-locked to the waveform of tonal stimuli, together with phase-independent inhibitory inputs are summated linearly. The result is transformed into a probability of spike generation by a sigmoid nonlinearity, constituting a stochastic, ’soft’ threshold with saturation. The model incorporates inhibition as a control parameter on the nonlinearity, and includes the usual crosscorrelation-type models as a special case. It has a minimum number of parameters, the values of which can be estimated from physiological data in a straightforward manner. This simple, general model accounts for the binaural response properties of physiologically recorded neurons. In particular, it explains the experimentally observed ITD-tuning and the increase of phase-locking from input to output neurons. The model predicts that a decrease in inhibition causes a non-monotonic change in sensitivity to ITD

TWINLATIN: Twinning European and Latin-American river basins for research enabling sustainable water resources management. Combined Report D3.1 Hydrological modelling report and D3.2 Evaluation report

Water use has almost tripled over the past 50 years and in some regions the water demand already exceeds supply (Vorosmarty et al., 2000). The world is facing a “global water crisis”; in many countries, current levels of water use are unsustainable, with systems vulnerable to collapse from even small changes in water availability. The need for a scientifically-based assessment of the potential impacts on water resources of future changes, as a basis for society to adapt to such changes, is strong for most parts of the world. Although the focus of such assessments has tended to be climate change, socio-economic changes can have as significant an impact on water availability across the four main use sectors i.e. domestic, agricultural, industrial (including energy) and environmental. Withdrawal and consumption of water is expected to continue to grow substantially over the next 20-50 years (Cosgrove & Rijsberman, 2002), and consequent changes in availability may drastically affect society and economies. One of the most needed improvements in Latin American river basin management is a higher level of detail in hydrological modelling and erosion risk assessment, as a basis for identification and analysis of mitigation actions, as well as for analysis of global change scenarios. Flow measurements are too costly to be realised at more than a few locations, which means that modelled data are required for the rest of the basin. Hence, TWINLATIN Work Package 3 “Hydrological modelling and extremes” was formulated to provide methods and tools to be used by other WPs, in particular WP6 on “Pollution pressure and impact analysis” and WP8 on “Change effects and vulnerability assessment”. With an emphasis on high and low flows and their impacts, WP3 was originally called “Hydrological modelling, flooding, erosion, water scarcity and water abstraction”. However, at the TWINLATIN kick-off meeting it was agreed that some of these issues resided more appropriately in WP6 and WP8, and so WP3 was renamed to focus on hydrological modelling and hydrological extremes. The specific objectives of WP3 as set out in the Description of Work are