Randomised comparison of oral and vaginal misoprostol when combined with mifepristone for termination of second trimester pregnancy

Background: Objective of the study was to compare the effectiveness of vaginal (200µg) and oral (400µg) misoprostol when combined with mifepristone (200 mg) in termination of second trimester pregnancy.Methods: 60 women who were pregnant between 13 and 20 weeks were included in the study. They were divided into two groups by random sampling method and they all received 200 mg of mifepristone orally on day 1. 36 hours later they received 200 µg of misoprostol vaginally or 400 µg of misoprostol orally every 3 hours as determined by the random sampling method. Main outcome measures were induction abortion interval, complete abortion rate and side effects.Results: There was a statistical difference in the amount of misoprostol required in the oral and the vaginal group, the total dose being higher in the oral group. The mean induction-abortion interval in the vaginal group was 6.2 hrs  and oral group was 11.6 hrs and this difference was statistically significant. There was no statistical difference in the complete abortion rate of the two groups. There was no difference in the side effects caused by both routes of misoprostol administration.Conclusion: 200 µg misoprostol inserted vaginally is better than 400 µg of oral misoprostol, 36 hours after administration of tab. Mifepristone 200 mg for termination of second trimester pregnancy

Standardization of Spacing and Soil Volume Wetting for Drip Irrigationin Papaya (Carica papaya L.)

Field experiments in two crops of papaya were conducted at ICAR-Indian Institute of Horticultural Research for four years during 2016-19 to standardise spacing with optimum soil volume wetting for drip irrigation. Narrowing the plant rows drastically reduced the plant height while leaf production affected significantly due to reduction in intra row spacing. The height at first fruiting was significantly lower with a spacing of 1.8 m x 1.5 m (56.4 cm) significantly differing from both 1.5 m x 1.5 m (60.9 cm) or 1.8 m x 1.8 m (66.8 cm). Significantly higher mean fruit yield (42.2 t/ha) was recorded with the spacing of 1.5 m x 1.5m as compared to either 1.8m x 1.5m (23.4 t/ha) or 1.8m x 1.8m (22.1 t/ha). Significantly higher water use efficiency (71.3 kg/ha.mm) was recorded in papaya by following closer spacing of 1.5 m x 1.5 m. Among the interactions, higher papaya yield (48.0 t/ha) was recorded with normal drip irrigation (80% soil volume wetting) under closer spacing (1.5 m. x 1.5 m). Further, higher water use efficiency (129 kg/ha. mm) could be obtained by scheduling the irrigation at 30% soil volume wetting especially by planting at 1.5 m. x 1.5 m. spacing suggesting its suitability for water scarcity areas

Partial root zone drying irrigation in papaya (Carica papaya L.) for enhanced water use efficiency under limited water situations

Field experiments were conducted during 2015-17 at ICAR-Indian Institute of Horticultural Research, Hessaraghatta, Bengaluru, to standardize the partial root zone drying irrigation in papaya with 12 treatments in RBD design. The results indicated that better soil moisture in the root zone could be maintained under drip irrigation by shifting laterals on either side at fortnightly intervals as compared to fixed laterals with thesame amount of water. Significantly more primary roots (16.5/plant) were observed when irrigation was scheduled on one side with single emitter meeting 60% of the evaporative demand. PRD irrigation through shifting of laterals recorded significantly higher transpiration rate especially at 50% of ER (8.05 m mol m-2 s-1) as compared to the control (3.95m mol m-2 s-1). Further, the same treatment recorded significantly lower fruit cavity index (0.26) with relatively higher fruit volume (1388 cm3). Irrigating papaya only on one side with single emitter resulted in significantly higher T.S.S (13.0%). Higher water productivity (23.7 kg/m3) could be obtained by scheduling the irrigation at 40% evaporation replenishment through shifting of laterals with saving of substantial water (1285m3/ha) resulting in higher water use efficiency (237.4 kg/ha.mm)

Comparative study (II): On the longevity of pupa and adult moths in selected few bivoltine purelines of silkworm Bombyx mori (L) in all the seasons of the year.

A comparative study utilizing the six multivoltines, in three seasons of the year between pupal and adult moth stage of silkworm of reveals a positive significance. Pupal duration was calculated after chrysalis stage among six multivoltines clearly indicated that the duration of pupae in the pre race is lowest where as the Daizo race exhibited the longest pupal duration of 240 hours. Silkworm adult life span evaluated in three seasons in the two sexes (male moth and female moth) it is clear that race pre exhibited shortest adult life span of 84 hours in mated males and 114 hours in mated females during pre-monsoon period and Daizo race revealed prolonged adult life span 222 hours in unmated males and 242 hours in unmated females during post-monsoon period. In the present studies among the two sexes, the unmated (virgin) male and females moths exhibited the longest life span than those of mated male and female moths. The influence of three seasons on adult life span is very clear from the experiment. The effect of pre-monsoon is more conspicuous (revealing short lifespan) where as in post-monsoon season lifespan is longest both in the pupal and adult. The results obtained from the present studies clearly demonstrate that racial differences, seasonal impact and sex wise differences are important in the expression of adult longevity

Standardisation of soil volume wetting for drip irrigation in mango (Mangifera indica L.,)

Field experiments were conducted in mango for four years during 2017-2020 at ICAR-Indian Institute of Horticultural Research to standardise optimum soil volume wetting for drip irrigation. Wetting soil volume upto 70% recorded higher mean fruit yield of 34.8 kg/plant (9.68 t/ha)and with further increase in the level of soil volume wetting irrigation (upto 80%), there was a decline in the mango yield (7.40 t/ha). Similarly, significantly increased response was observed in fruit weight upto 70% soil volume irrigation (226 g) although there were no significant differences in the TSS of the fruit. Significantly higher water use efficiency was observed for 30% soil volume wetting irrigation (274.1 kg/m3) and further no significant differences were observed in water use efficiency between 50% and 70% soil volume wetting irrigations indicating that in areas of water scarcity, it is enough to scheduling the irrigation only upto 50% soil volume wetting in mango for economising the water (232.1 kg/m3)

Comparative study between open versus laparoscopic inguinal hernioplasty

Background: Inguinal hernia repair is one of the commonly performed procedure and has undergone a paradigm shift from open to laparoscopic approach in the era of minimally invasive surgery but the superiority is still debatable. The aim was to compare open (Lichtenstein) versus laparoscopic transabdominal preperitoneal approach (TAPP) hernia repair techniques. Methods: A total of 60 patients were enrolled in the study and divided into two equal groups (open versus laparoscopic) were compared. Results: It was observed that laparoscopic repair (TAPP) has statistically significant superiority than open inguinal hernioplasty in terms of lesser post-operative pain (VAS score of 4.8±0.66, 3.67±0.66, 2.53±0.82 versus 6.7±0.92, 5.03±0.72, 3.83±0.65 at 24 hours, 48 hours and 72 hours post operatively, p value <0.001), shorter duration of hospital stay (3.1±0.71 days versus 5.83±0.75 days, p value <0.001) and early resumption to regular activities (10.57±2.28 days versus 12.2±1.52 days, p value 0.002). It also showed that incidence intra operative and post-operative complications was lesser in laparoscopic group but not statistically significant. Whereas duration of surgery was prolonged in laparoscopic group (104±27.49 min versus 61.5±17.08 min, p value <0.001). Conclusions: Laparoscopic inguinal hernioplasty (TAPP) is superior to open inguinal hernioplasty in terms of lesser intra operative and post-operative complications, lesser post-operative pain, shorter duration of hospital stay with early resumption to regular activities having better subjective and objective cosmetic results in short term follow-up. However, duration of surgery was prolonged on comparison with Lichtenstein open inguinal hernioplasty

Beyond Breathless: Unravelling The Enigma Of Pulmonary Arteriovenous Malformations

Pulmonary Arteriovenous Malformations (AVMs) are abnormal connections between the pulmonary arteries and veins, leading to a direct shunting of blood without passing through the normal capillary bed. These AVMs can be associated with a rare genetic disorder called Hereditary Hemorrhagic Telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome. HHT is an autosomal dominant disorder characterized by the development of fragile telangiectasias in various organs, including the skin and mucous membranes. These telangiectasias are prone to bleeding, leading to recurrent nosebleeds and mucocutaneous bleeding. In patients with HHT, the most common site of AVMs is in the lungs. Pulmonary AVMs can cause significant health risks due to the right-to-left shunting of blood, leading to hypoxemia and possible complications like stroke, cerebral abscesses, and heart failure

N-[4-Cyano-3-(trifluoro­meth­yl)phen­yl]-2-eth­oxy­benzamide

In the title compound, C17H13F3N2O2, the two aromatic rings are essentially coplanar, forming a dihedral angle of 2.78 (12)°. The non-H atoms of the eth­oxy group are coplanar with the attached ring [maximum deviation = 0.271 (3) Å]. An intra­molecular N—H⋯O hydrogen bond occurs. In the crystal structure, mol­ecules are linked by inter­molecular C—H⋯N and C—H⋯F hydrogen bonds

N-[4-Cyano-3-(trifluoro­meth­yl)phen­yl]-2-meth­oxy­benzamide

In the title compound, C16H11F3N2O2, the carboxamide group connecting the two aromatic rings is in a syn-periplanar configuration; the mol­ecule is non-planar; the dihedral angle between the two aromatic rings is 13.95 (18)°. Intra­molecular N—H⋯O and C—H⋯O hydrogen bonds occur. In the crystal, mol­ecules are linked by inter­molecular C—H⋯O hydrogen bonds