1,317 research outputs found
Bebida contendo abacaxi (Ananas comosus) e beterraba (Beta vulgaris) para crianças: tratar termicamente ou não?
Edição dos Resumos do VI Congresso Latinoamericano e XII Congresso Brasileiro de Higienistas de Alimentos, II Encontro Nacional de Vigilância das Zoonoses, IV Encontro do Sistema Brasileiro de Inspeção de Produtos de Origem Animal, Gramado, abr. 2013
Casimir forces in modulated systems
For the first time we present analytical results for the contribution of
electromagnetic fluctuations into thermodynamic properties of modulated
systems, like cholesteric or smectic liquid crystalline films. In the case of
small dielectric anisotropy we have derived explicit analytical expressions for
the chemical potential of such systems. Two limiting cases were specifically
considered: (i) the Van der Waals (VdW) limit, i.e., in the case when the
retardation of the electromagnetic interactions can be neglected; and (ii) the
Casimir limit, i.e. when the effects of retardation becomes considerable. It
was shown that in the Casimir limit, the film chemical potential oscillates
with the thickness of the film. This non-monotonic dependence of the chemical
potential on the film thickness can lead to step-wise wetting phenomena,
surface anchoring reorientation and other important effects. Applications of
the results may concern the various systems in soft matter or condensed matter
physics with multilayer or modulated structures.Comment: 13 page
Population pharmacokinetics of lopinavir and ritonavir in combination with rifampicin-based antitubercular treatment in HIV-infected children
Children with HIV associated tuberculosis often require co-formulated lopinavir/ritonavir (LPV/RTV)-based antiretroviral treatment with rifampicin-based antitubercular treatment (ATT). Rifampicin (RIF), a potent inducer of drug-metabolizing systems, profoundly reduces the bioavailability of LPV. The aims of this study were to develop an integrated population pharmacokinetic (PK) model describing LPV and RTV PK in children with and without concomitant ATT using two different dosing approaches and to estimate doses of LPV/RTV achieving target exposures during ATT in young children
Dynamic Fluctuation Phenomena in Double Membrane Films
Dynamics of double membrane films is investigated in the long-wavelength
limit including the overdamped squeezing mode. We demonstrate that thermal
fluctuations essentially modify the character of the mode due to its nonlinear
coupling to the transversal shear hydrodynamic mode. The corresponding Green
function acquires as a function of the frequency a cut along the imaginary
semi-axis. Fluctuations lead to increasing the attenuation of the squeezing
mode it becomes larger than the `bare' value.Comment: 7 pages, Revte
Correlated terahertz acoustic and electromagnetic emission in dynamically screened InGaN/GaN quantum wells
We investigate acoustic and electromagnetic emission from optically excited strained piezoelectric In0.2Ga0.8N/GaN multiple quantum wells (MQWs), using optical pump-probe spectroscopy, time-resolved Brillouin scattering, and THz emission spectroscopy. A direct comparison of detected acoustic signals and THz electromagnetic radiation signals demonstrates that transient strain generation in InGaN/GaN MQWs is correlated with electromagnetic THz generation, and both types of emission find their origin in ultrafast dynamical screening of the built-in piezoelectric field in the MQWs. The measured spectral intensity of the detected Brillouin signal corresponds to a maximum strain amplitude of generated acoustic pulses of 2%. This value coincides with the static lattice-mismatch-induced strain in In0.2Ga0.8N/GaN, demonstrating the total release of static strain in MQWs via impulsive THz acoustic emission. This confirms the ultrafast dynamical screening mechanism in MQWs as a highly efficient method for impulsive strain generatio
Coexistence and Phase Separation in Sheared Complex Fluids
We demonstrate how to construct dynamic phase diagrams for complex fluids
that undergo transitions under flow, in which the conserved composition
variable and the broken-symmetry order parameter (nematic, smectic,
crystalline, etc.) are coupled to shear rate. Our construction relies on a
selection criterion, the existence of a steady interface connecting two stable
homogeneous states. We use the (generalized) Doi model of lyotropic nematic
liquid crystals as a model system, but the method can be easily applied to
other systems, provided non-local effects are included.Comment: 4 pages REVTEX, 5 figures using epsf macros. To appear in Physical
Review E (Rapid Communications
Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury
Peribiliary glands (PBG) are a source of stem/progenitor cells organized in a cellular network encircling large bile ducts. Severe cholangiopathy with loss of luminal biliary epithelium has been proposed to activate PBG, resulting in cell proliferation and differentiation to restore biliary epithelial integrity. However, formal evidence for this concept in human livers is lacking. We, therefore, developed a novel ex vivo model using precision-cut slices of extrahepatic human bile ducts obtained from discarded donor livers, providing an intact anatomical organization of cell structures, to study spatiotemporal differentiation and migration of PBG cells after severe biliary injury. Post-ischemic bile duct slices were incubated in oxygenated culture medium for up to a week. At baseline, severe tissue injury was evident with loss of luminal epithelial lining and mural stroma necrosis. In contrast, PBG remained relatively well preserved and different reactions of PBG were noted, including PBG dilatation, cell proliferation and maturation. Proliferation of PBG cells increased after 24 h of oxygenated incubation, reaching a peak after 72 h. Proliferation of PBG cells was paralleled by a reduction in PBG apoptosis and differentiation from a primitive and pluripotent (Nanog+/Sox9+) to a mature (CFTR+/secretin receptor+) and activated phenotype (increased expression of HIF-1α, Glut-1, and VEGF-A). Migration of proliferating PBG cells in our ex vivo model was unorganized, but resulted in generation of epithelial monolayers at stromal surfaces. CONCLUSION: Human PBG contain biliary progenitor cells and are able to respond to bile duct epithelial loss with proliferation, differentiation, and maturation to restore epithelial integrity. The ex vivo spatiotemporal behaviour of human PBG cells provides evidence for a pivotal role of PBG in biliary regeneration after severe injury. This article is protected by copyright. All rights reserved
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