Subjective localization of electrocutaneous stimuli

Studying the perception of spatiotemporal stimulus patterns in various modalities may yield important information on the way in which humans process sensory information. The perception of tactile and nociceptive cutaneous stimulus patterns have been studied by Stolle et al. [1] and Trojan et al. [2][4] respectively. Among other things, both authors studied subjective localization of single stimuli. In Trojan et al. [4], two types of mislocalization patterns were observed for nociceptive single stimuli when comparing the localization reports with the stimulus locations: (1) overall proximal or distal displacement and (2) expansion or contraction of the stimulus area.\ud It is unknown whether tactile and nociceptive stimuli at the same skin site are perceived as being at the same site. Therefore, comparing the spatial perception of tactile and nociceptive cutaneous stimuli may provide new insights into their processing. This comparison can only be successfully made by applying nociceptive and tactile stimuli at the same skin site in the same experiment. This can be done by using a device which has recently been developed at our institute and which we refer to as the bimodal stimulation electrode [3]. \ud Recording the perceived locations of stimuli can be done by letting subjects report these on a scale. The most intuitive scale for this is the stimulated arm itself. However, this would bias the perception of stimulus location by providing visual information of the electrode locations. The goal of the present research was to (1) create and (2) test a setup which allows subjects to report perceived stimulus locations on their own arm without seeing the electrode positions. This was achieved by building a setup consisting of a touch screen (Provision Visboard) which presents a digital image of the subject’s own arm (without electrodes) and which is positioned over this arm after the electrodes have been attached. Subjects can report the localizations by pointing at the screen using a pointer

Looking for outflow and infall signatures in high mass star forming regions

(Context) Many physical parameters change with time in star forming regions. Here we attempt to correlate changes in infall and outflow motions in high mass star forming regions with evolutionary stage using JCMT observations. (Aims) From a sample of 45 high mass star forming regions in three phases of evolution, we investigate the presence of established infall and outflow tracers to determine whether there are any trends attributable to the age of the source. (Methods) We obtained JCMT observations of HCO+/H13CO+ J=4-3 to trace large scale infall, and SiO J=8-7 to trace recent outflow activity. We compare the infall and outflow detections to the evolutionary stage of the host source (high mass protostellar objects, hypercompact HII regions and ultracompact HII regions). We also note that the integrated intensity of SiO varies with the full width at half maximum of the H13CO+. (Results) We find a surprising lack of SiO detections in the middle stage (Hypercompact HII regions), which may be due to an observational bias. When SiO is detected, we find that the integrated intensity of the line increases with evolutionary stage. We also note that all of the sources with infall signatures onto Ultracompact HII regions have corresponding outflow signatures as well.Comment: 9 pages, 5 figures, 5 tables. Accepted by A&

Costs, Sulfur Emissions and Deposition of the EC Directive on Large Combustion Plants

The European Community (EC) has agreed upon a Directive to reduce acidifying emissions from large combustion installations. This policy sets emissions standards for new plants and requires an overall reduction in emissions from existing ones. As a result sulfur dioxide emissions in the EC will be reduced by an additional 15% over national legislation. The annual costs of the Directive are estimated at DM 9.2 billion, DM 3.1 billion more than the present national legislation. The area exposed to a sulfur deposition higher than 1 gram will decrease. However, the same emission reductions could have been reached with only DM 6.3 billion of annual costs

Why Frequency Matters for Unit Root Testing

It is generally believed that for the power of unit root tests, only the time span and not the observation frequency matters. In this paper we show that the observation frequency does matter when the high-frequency data display fat tails and volatility clustering, as is typically the case for financial time series such as exchange rate returns. Our claim builds on recent work on unit root and cointegration testing based non-Gaussian likelihood functions. The essential idea is that such methods will yield power gains in the presence of fat tails and persistent volatility clustering, and the strength of these features (and hence the power gains) increases with the observation frequency. This is illustrated using both Monte Carlo simulations and empirical applications to real exchange rates

Computational Screening of Tip and Stalk Cell Behavior Proposes a Role for Apelin Signaling in Sprout Progression

Angiogenesis involves the formation of new blood vessels by sprouting or splitting of existing blood vessels. During sprouting, a highly motile type of endothelial cell, called the tip cell, migrates from the blood vessels followed by stalk cells, an endothelial cell type that forms the body of the sprout. To get more insight into how tip cells contribute to angiogenesis, we extended an existing computational model of vascular network formation based on the cellular Potts model with tip and stalk differentiation, without making a priori assumptions about the differences between tip cells and stalk cells. To predict potential differences, we looked for parameter values that make tip cells (a) move to the sprout tip, and (b) change the morphology of the angiogenic networks. The screening predicted that if tip cells respond less effectively to an endothelial chemoattractant than stalk cells, they move to the tips of the sprouts, which impacts the morphology of the networks. A comparison of this model prediction with genes expressed differentially in tip and stalk cells revealed that the endothelial chemoattractant Apelin and its receptor APJ may match the model prediction. To test the model prediction we inhibited Apelin signaling in our model and in an \emph{in vitro} model of angiogenic sprouting, and found that in both cases inhibition of Apelin or of its receptor APJ reduces sprouting. Based on the prediction of the computational model, we propose that the differential expression of Apelin and APJ yields a "self-generated" gradient mechanisms that accelerates the extension of the sprout.Comment: 48 pages, 10 figures, 8 supplementary figures. Accepted for publication in PLoS ON

High Resolution CO Observations of Massive Star Forming Regions

Context. To further understand the processes involved in the formation of massive stars, we have undertaken a study of the gas dynamics surrounding three massive star forming regions. By observing the large scale structures at high resolution, we are able to determine properties such as driving source, and spatially resolve the bulk dynamical properties of the gas such as infall and outflow. Aims. With high resolution observations, we are able to determine which of the cores in a cluster forming massive stars is responsible for the large scale structures. Methods. We present CO observations of three massive star forming regions with known HII regions and show how the CO traces both infall and outflow. By combining data taken in two SMA configurations with JCMT observations, we are able to see large scale structures at high resolution. Results. We find large (0.26-0.40 pc), massive (2-3 M_sun) and energetic (13-17 \times 10^44 erg) outflows emanating from the edges of two HII regions suggesting they are being powered by the protostar(s) within. We find infall signatures in two of our sources with mass infall rates of order 10-4 M_sun/yr. Conclusions. We suggest that star formation is ongoing in these sources despite the presence of HII regions. We further conclude that the source(s) within a single HII region are responsible for the observed large scale structures; that these large structures are not the net effect of multiple outflows from multiple HII regions and hot cores.Comment: 8 pages,2 figures, accepted for publication in A&

Possible impacts of climate change on freezing rain in south-central Canada using downscaled future climate scenarios

Freezing rain is a major atmospheric hazard in mid-latitude nations of the globe. Among all Canadian hydrometeorological hazards, freezing rain is associated with the highest damage costs per event. Using synoptic weather typing to identify the occurrence of freezing rain events, this study estimates changes in future freezing rain events under future climate scenarios for south-central Canada. Synoptic weather typing consists of principal components analysis, an average linkage clustering procedure (i.e., a hierarchical agglomerative cluster method), and discriminant function analysis (a nonhierarchical method). Meteorological data used in the analysis included hourly surface observations from 15 selected weather stations and six atmospheric levels of six-hourly National Centers for Environmental Prediction (NCEP) upper-air reanalysis weather variables for the winter months (November&ndash;April) of 1958/59&ndash;2000/01. A statistical downscaling method was used to downscale four general circulation model (GCM) scenarios to the selected weather stations. Using downscaled scenarios, discriminant function analysis was used to project the occurrence of future weather types. The within-type frequency of future freezing rain events is assumed to be directly proportional to the change in frequency of future freezing rain-related weather types <br><br> The results showed that with warming temperatures in a future climate, percentage increases in the occurrence of freezing rain events in the north of the study area are likely to be greater than those in the south. By the 2050s, freezing rain events for the three colder months (December&ndash;February) could increase by about 85% (95% confidence interval &ndash; CI: &plusmn;13%), 60% (95% CI: &plusmn9%), and 40% (95% CI: &plusmn;6%) in northern Ontario, eastern Ontario (including Montreal, Quebec), and southern Ontario, respectively. The increase by the 2080s could be even greater: about 135% (95% CI: &plusmn;20%), 95% (95% CI: &plusmn;13%), and 45% (95% CI: &plusmn;9%). For the three warmer months (November, March, April), the percentage increases in future freezing rain events are projected to be much smaller with some areas showing either a decrease or little change in frequency of freezing rain. On average, northern Ontario could experience about 10% (95% CI: &plusmn;2%) and 20% (95% CI: &plusmn;4%) more freezing rain events by the 2050s and 2080s, respectively. However, future freezing rain events in southern Ontario could decrease about 10% (95% CI: &plusmn;3%) and 15% (95% CI: &plusmn;5%) by the 2050s and 2080s, respectively. In eastern Ontario (including Montreal, Quebec), the frequency of future freezing rain events is projected to remain the same as it is currently

Assessment and visualisation of daily-life arm movements after stroke

For an optimal guidance of the rehabilitation therapy of stroke patients in an in-home setting, objective, and patient specific assessment of upper extremity task performance is needed. Towards this goal, metrics of hand position relative to the pelvis were estimated and visualized. Metrics, including work area and maximum reaching distance, appeared to strongly correlate with the upper extremity part of the Fugl-Meyer Assessment scale (r>0.84, p<0.001). Proposed metrics and visualisation can be used to objectively assess the arm movement performance over a longer period of time in a daily-life setting, if combined with info about performed task derived from a activity monitor