Manipulating Memory Associations Changes Decision-making Preferences in a Preconditioning Task

Memories of past experiences can guide our decisions. Thus, if memories are undermined or distorted, decision making should be affected. Nevertheless, little empirical research has been done to examine the role of memory in reinforcement decision-making . We hypothesized that if memories guide choices in a conditioning decision-making task, then manipulating these memories would result in a change of decision preferences to gain reward. We manipulated participants’ memories by providing false feedback that their memory associations were wrong before they made decisions that could lead them to win money . Participants’ memory ratings decreased significantly after receiving false feedback. More importantly, we found that false feedback led participants’ decision bias to disappear after their memory associations were undermined . Our results suggest that reinforcement decision-making can be altered by fasle feedback on memories . The results are discussed using memory mechanisms such as spreading activation theories

The nature and consequences of false memories for visual stimuli

Different theoretical views exist regarding whether false memories contain perceptual information or are merely conceptual in nature. To address this question, we conducted three experiments to examine whether false memories for pictures had a priming effect on a perceptual closure task. In Experiment 1, participants were presented with pictorial versions of Deese/Roediger - McDermott (DRM) lists and received a recognition task. Finally, in the perceptual closure task (PCT), participants were shown degraded pictures (studied pictures, critical pictures , unrelated pictures) that became clearer over time and had to identify the object depicted as quickly as possible. The results showed that false memories for pictures did not exhibit a priming effect in the PCT. Specifically, picture identifications based on false memories for visual stimuli were significantly slower than those based on true memories and the former did not differ from that of unrelated items . In Experiments 2 and 3, we manipulated the modality (ve rbal vs. pictorial) of the study phase and the PCT phase . In both experiments , false memories for pictures primed pictures significantly slower than true memories in the pictorial PCT, but false memories for pictures primed words faster than true memories in the verbal PCT. Our results suggest that false memories for pictures are unlikely to contain perceptual information but rather that they are conceptual in nature

The nature and consequences of false memories for visual stimuli

Different theoretical views exist regarding whether false memories contain perceptual information or are merely conceptual in nature. To address this question, we conducted three experiments to examine whether false memories for pictures had a priming effect on a perceptual closure task. In Experiment 1, participants were presented with pictorial versions of Deese/Roediger - McDermott (DRM) lists and received a recognition task. Finally, in the perceptual closure task (PCT), participants were shown degraded pictures (studied pictures, critical pictures , unrelated pictures) that became clearer over time and had to identify the object depicted as quickly as possible. The results showed that false memories for pictures did not exhibit a priming effect in the PCT. Specifically, picture identifications based on false memories for visual stimuli were significantly slower than those based on true memories and the former did not differ from that of unrelated items . In Experiments 2 and 3, we manipulated the modality (ve rbal vs. pictorial) of the study phase and the PCT phase . In both experiments , false memories for pictures primed pictures significantly slower than true memories in the pictorial PCT, but false memories for pictures primed words faster than true memories in the verbal PCT. Our results suggest that false memories for pictures are unlikely to contain perceptual information but rather that they are conceptual in nature

The Consequences of Implicit and Explicit Beliefs on Food Preferences

Memories can have consequences on people's eating behavior. In the current experiment, we examined the effect of belief versus recollection on food preferences and then investigated whether explicit belief (i.e., self- reported) or implicit belief (i.e., measured by an autobiographical implicit association test; aIAT) had a similar effect on food preferences. Participants (N = 163) were falsely told that they got sick after eating egg salad in their childhood and then received guided imagery to induce false beliefs/recollections concerning the food-aversive event. Half of the participants with false memories were debriefed and told that the event was false to reduce their belief in the event. Belief, not recollection regarding the food-aversive event, impacted participants' food preferences. Furthermore, we found that explicit, but not implicit, belief predicted participants' food preferences. The current results suggest that explicit judgments of belief in a memory may explain the consequences resulting from memories

Phase I study of high-dose epirubicin and vinorelbine in previously untreated non-small-cell lung cancer stage IIIB-IV.

The aim of the study was to determine the maximum tolerated dose (MTD) for the combination of high-dose epirubicin and vinorelbine in chemotherapy-naive patients with inoperable non-small-cell lung cancer (NSCLC). Twenty-one patients with stage IIIB and IV NSCLC were treated in a single-centre study with escalating doses of epirubicin and vinorelbine given on an outpatient basis. The first dose level comprised epirubicin 100 mg m-2 on day 1 and vinorelbine 20 mg m-2 (days 1 and 8) given intravenously every 3 weeks. Escalating doses for epirubicin and vinorelbine were respectively 120 (day 1) and 20 (days 1 and 8), 120 (day 1) and 25 (days 1 and 8) and 135 (day 1) and 25 (days 1 and 8) mg m-2. Inclusion criteria were age < or = 75 years, ECOG performance score < or = 2 and normal renal, hepatic and bone marrow functions. Dose-limiting toxicities were thrombocytopenia grade II and neutropenia grade III on day 8, febrile neutropenia, and neutropenia lasting > 7 days. No dose-limiting toxicity (DLT) was observed at the first dose level; at the 135/25 mg m-2 dose level three out of six patients had a DLT which was considered as unacceptable. The only non-haematological toxicity reaching grade III was nausea/vomiting. One patient showed cardiac toxicity. No neurotoxicity and no treatment-related deaths were seen. The maximum tolerated dose of epirubicin and vinorelbine is 135 mg m-2 (day 1) and 25 mg m-2 (days 1 and 8) respectively, causing mainly haematological toxicity. The recommended dose of epirubicin and vinorelbine for phase II studies is found to be 120 mg m-2 and 20 mg m-2 respectively

Grasping trapezoidal objects

When grasping rectangular or circular objects with a precision grip the digits close in on the object in opposite directions. In doing so the digits move perpendicular to the local surface orientation as they approach opposite sides of the object. This perpendicular approach is advantageous for accurately placing the digits. Trapezoidal objects have non-parallel surfaces so that moving the digits in opposite directions would make the digits approach the contact surfaces at an angle that is not 90°. In this study we examined whether this happens, or whether subjects tend to approach trapezoidal objects’ surfaces perpendicularly. We used objects of different sizes and with different surface slants. Subjects tended to approach the object’s surfaces orthogonally, suggesting that they aim for an optimal precision of digit placement rather than simply closing their hand as it reaches the object

Metabolism and growth inhibition of four retinoids in head and neck squamous normal and malignant cells

Isotretinoin (13- cis -retinoic acid, 13cRA) has proven to be active in chemoprevention of head and neck squamous cell carcinoma (HNSCC). Moreover, both all-trans-retinoic acid (ATRA) and 13cRA induce objective responses in oral premalignant lesions. After binding of retinoids to retinoic acid receptors (RARs and RXRs) dimers are formed that are able to regulate the expression of genes involved in growth and differentiation. We compared the metabolism and level of growth inhibition of 13cRA with that of ATRA, 9cRA and retinol in four HNSCC cell lines and normal oral keratinocyte cultures (OKC). These retinoid compounds are known to bind with different affinities to the retinoic acid receptors. We observed that all retinoids were similar with respect to their capacity to induce growth inhibition. One HNSCC line could be ranked as sensitive, one as moderately sensitive and the remaining two were totally insensitive; OKC were moderately sensitive. The rate at which the cells were able to catabolize the retinoid was similar for all compounds. Retinoid metabolism in HNSCC cells resulted in a profile of metabolites that was unique for each retinoid. These metabolic profiles were different in OKC. Our findings indicate that differences in retinoid receptor selectivity of these retinoids do not influence the level of growth inhibition and rate of metabolism. © 2001 Cancer Research Campaign http://www.bjcancer.co

Subtherapeutic triazole concentrations as result of a drug-drug interaction with lumacaftor/ivacaftor

Lumacaftor/ivacaftor (Orkambi®, LUM/IVA) is indicated for the treatment of cystic fibrosis (CF) patients aged ≥ 2 years with homozygous F580del mutation in the CFTR gene. Triazole fungal agents are used to treat fungal disease in CF. The use of triazoles is limited by pharmacokinetic challenges, such as drug-drug interactions. The most notable drug-drug interaction between triazoles and LUM/IVA is due to strong induction of CYP3A4 and UGT by LUM. In this real-world retrospective observational study, we described the effect of LUM/IVA on the trough concentration of triazoles. Concomitant use of LUM/IVA with itraconazole, posaconazole or voriconazole resulted in subtherapeutic triazole levels in 76% of the plasma samples. In comparison, in patients with triazole agents without LUM/IVA only 30.6% of the plasma samples resulted in subtherapeutic concentrations. Subtherapeutic plasma concentrations of triazoles should be considered in CF patients on LUM/IVA and further research is warranted for other dosing strategies and alternative antifungal therapy.</p

Subtherapeutic triazole concentrations as result of a drug-drug interaction with lumacaftor/ivacaftor

Lumacaftor/ivacaftor (Orkambi®, LUM/IVA) is indicated for the treatment of cystic fibrosis (CF) patients aged ≥ 2 years with homozygous F580del mutation in the CFTR gene. Triazole fungal agents are used to treat fungal disease in CF. The use of triazoles is limited by pharmacokinetic challenges, such as drug-drug interactions. The most notable drug-drug interaction between triazoles and LUM/IVA is due to strong induction of CYP3A4 and UGT by LUM. In this real-world retrospective observational study, we described the effect of LUM/IVA on the trough concentration of triazoles. Concomitant use of LUM/IVA with itraconazole, posaconazole or voriconazole resulted in subtherapeutic triazole levels in 76% of the plasma samples. In comparison, in patients with triazole agents without LUM/IVA only 30.6% of the plasma samples resulted in subtherapeutic concentrations. Subtherapeutic plasma concentrations of triazoles should be considered in CF patients on LUM/IVA and further research is warranted for other dosing strategies and alternative antifungal therapy.</p