Infrared renormalons and single meson production in proton-proton collisions

In this article, we investigate the contribution of the higher twist Feynman diagrams to the large-$p_T$ inclusive pion production cross section in proton-proton collisions and present the general formulae for the higher twist differential cross sections in the case of the running coupling and frozen coupling approaches. The structure of infrared renormalon singularities of the higher twist subprocess cross section and the resummed expression (the Borel sum) for it are found. We compared the resummed higher twist cross sections with the ones obtained in the framework of the frozen coupling approximation and leading twist cross section. We obtain, that ratio $R$ for all values of the transverse momentum $p_{T}$ of the pion identical equivalent to ratio $r$. It is shown that the resummed result depends on the choice of the meson wave functions used in calculation. Phenomenological effects of the obtained results are discussed.Comment: 28 pages, 13 figure

Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial

Few treatments with a distinct mechanism of action are available for patients with platinum-refractory advanced or metastatic urothelial carcinoma. We assessed the efficacy and safety of treatment with docetaxel plus either ramucirumab-a human IgG1 VEGFR-2 antagonist-or placebo in this patient population

Prrx1 controls endodermal organ laterality in vertebrates

Resumen del póster presentado al European Developmental Biology Congress (EDBC), celebrado en Alicante del 23 al 26 de octubre de 2019.The establishment of left-right asymmetries is crucial during embryonic development for the proper positioning and morphogenesis of internal organs. A transient L/R asymmetric expression of Prrx1 in the lateral plate mesoderm (LMP) leads to L/R asymmetric cell movements that displace the posterior pole of the heart to the left, promoting its normal position. We have now examined whether a similar mechanism in also involved in the lateralization of endodermal organs. We show here that prrx1a “crispant” zebrafish embryos present gut looping defects together with abnormal positioning of the liver and pancreas all remaining at their initial position in the midline. A prrx1a expression reporter line shows that LPM cells descendants from prrx1a+ cells have a L/R asymmetric pattern of migration. Cells from the right LPM move ventrally as previously described and push the gut to left. In prrx1a crispants, this migratory pathway if defective, disturbing not only the displacement of the gut from the midline but also affecting the cellular organisation and morphological asymmetry of the LPM. We also show that this mechanism is conserved in chick embryo. Thus, we propose that, similarly to the situation in the heart, a differential L/R EMT regulates the epithelial and migratory properties of the LPM and drives endodermal organ laterality in vertebrates.Peer reviewe

Carnitine levels in patients with chronic rheumatic heart disease

Objective: Carnitine, a small aminoacid derivative plays a major role in fatty acid oxidation. Myocardial carnitine deficiency may cause malfunction of the heart. Rheumatic valvular heart disease can be associated with myocardial dysfunction. We have investigated myocardial and plasma-free carnitine levels in patients with chronic rheumatic heart disease

Reply to: Zebrafish prrx1a mutants have normal hearts

Work in the laboratory is supported by grants from the Ministry of Science and Innovation through the Spanish State Research Agency (AEI) (MICIU RTI2018-096501-B-I00) and from Generalitat Valenciana (PROMETEOII/2017/150). M.A.N. also acknowledges the ‘Severo Ochoa’ Programme for Centres of Excellence in R&D (SEV-2017-0273) to Instituto de Neurociencias.Peer reviewe