1,857 research outputs found
Isolated Light Chain of Tetanus Toxin Inhibits Exocytosis: Studies in Digitonin-Permeabilized Cells
Previous work indicates that the heavy chain of tetanus toxin is responsible for the binding of the toxin to the neuronal membrane and its subsequent internalization. In the present study, the light chain of tetanus toxin mimicked the holotoxin in inhibiting Ca 2+ -dependent secretion of [ 3 H]norepinephrine from digitonin-permeabilized adrenal chromaffin cells. Preincubation of tetanus toxin with monoclonal antibodies to the light chain prevented the inhibition by tetanus toxin. Preincubation of tetanus toxin with nonimmune ascites fluid or with monoclonal antibodies directed against the C fragment (the C-terminal of the heavy chains or the heavy-chain portion of the B fragment did not prevent inhibition by tetanus toxin. The data indicate that the light chain is responsible for the intracellular blockade of exostosis.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65694/1/j.1471-4159.1989.tb11800.x.pd
On Neutrinos and Fermionic Mass Patterns
Recent data on neutrino mass differences are consistent with a hierarchical
neutrino mass structure strikingly similar to what is observed for the other
fermionic masses.Comment: 8pages, 2figure
Muon Simulations for Super-Kamiokande, KamLAND and CHOOZ
Muon backgrounds at Super-Kamiokande, KamLAND and CHOOZ are calculated using
MUSIC. A modified version of the Gaisser sea level muon distribution and a
well-tested Monte Carlo integration method are introduced. Average muon energy,
flux and rate are tabulated. Plots of average energy and angular distributions
are given. Implications on muon tracker design for future experiments are
discussed.Comment: Revtex4 33 pages, 16 figures and 4 table
No anomalous supersaturation in ultracold cirrus laboratory experiments
High-altitude cirrus clouds are climatically important: their formation freeze-dries air ascending to the stratosphere to its final value, and their radiative impact is disproportionately large. However, their formation and growth are not fully understood, and multiple in situ aircraft campaigns have observed frequent and persistent apparent water vapor supersaturations of 5 %–25 % in ultracold cirrus (T<205 K), even in the presence of ice particles. A variety of explanations for these observations have been put forth, including that ultracold cirrus are dominated by metastable ice whose vapor pressure exceeds that of hexagonal ice. The 2013 IsoCloud campaign at the Aerosol Interaction and Dynamics in the Atmosphere (AIDA) cloud and aerosol chamber allowed explicit testing of cirrus formation dynamics at these low temperatures. A series of 28 experiments allows robust estimation of the saturation vapor pressure over ice for temperatures between 189 and 235 K, with a variety of ice nucleating particles. Experiments are rapid enough (∼10 min) to allow detection of any metastable ice that may form, as the timescale for annealing to hexagonal ice is hours or longer over the whole experimental temperature range. We show that in all experiments, saturation vapor pressures are fully consistent with expected values for hexagonal ice and inconsistent with the highest values postulated for metastable ice, with no temperature-dependent deviations from expected saturation vapor pressure. If metastable ice forms in ultracold cirrus clouds, it appears to have a vapor pressure indistinguishable from that of hexagonal ice to within about 4.5 %
Effects of combined exposures of fluoranthene and polyethylene or polyhydroxybutyrate microplastics on oxidative stress biomarkers in the blue mussel (Mytilus edulis)
Direct versus indirect detection in mSUGRA with self-consistent halo models
We perform a detailed analysis of the detection prospects of neutralino dark
matter in the mSUGRA framework. We focus on models with a thermal relic
density, estimated with high accuracy using the DarkSUSY package, in the range
favored by current precision cosmological measurements. Direct and indirect
detection rates are computed implementing two models for the dark matter halo,
tracing opposite regimes for the phase of baryon infall, with fully consistent
density profiles and velocity distribution functions. This has allowed, for the
first time, a fully consistent comparison between direct and indirect detection
prospects. We discuss all relevant regimes in the mSUGRA parameter space,
underlining relevant effects, and providing the basis for extending the
discussion to alternative frameworks. In general, we find that direct detection
and searches for antideuterons in the cosmic rays seems to be the most
promising ways to search for neutralinos in these scenarios.Comment: 26 pages, 9 figure
Search for Dark Matter WIMPs using Upward Through-going Muons in Super-Kamiokande
We present the results of indirect searches for Weakly Interacting Massive
Particles (WIMPs) with 1679.6 live days of data from the Super-Kamiokande
detector using neutrino-induced upward through-going muons. The search is
performed by looking for an excess of high energy muon neutrinos from WIMP
annihilations in the Sun, the core of the Earth, and the Galactic Center, as
compared to the number expected from the atmospheric neutrino background. No
statistically significant excess was seen. We calculate flux limits in various
angular cones around each of the above celestial objects. We obtain
conservative model-independent upper limits on WIMP-nucleon cross-section as a
function of WIMP mass and compare these results with the corresponding results
from direct dark matter detection experiments.Comment: 10 pages, 14 figures, Submitted to Phys. Rev.
- …