Spin and Orbital Splitting in Ferromagnetic Contacted Single Wall Carbon Nanotube Devices

We observed the coulomb blockade phenomena in ferromagnetic contacting single wall semiconducting carbon nanotube devices. No obvious Coulomb peaks shift was observed with existing only the Zeeman splitting at 4K. Combining with other effects, the ferromagnetic leads prevent the orbital spin states splitting with magnetic field up to 2 Tesla at 4K. With increasing magnetic field further, both positive or negative coulomb peaks shift slopes are observed associating with clockwise and anticlockwise orbital state splitting. The strongly suppressed/enhanced of the conductance has been observed associating with the magnetic field induced orbital states splitting/converging

Spectral element - Fourier methods applied to simulation of turbulent pipe flow

This paper is made available with the permission of the Australian Mathematical Society Inc.We present results from direct numerical simulations of turbulent pipe flow at a Reynolds number of 5000. The spatial discretisation employs Fourier expansions in one geometrically homogeneous direction coupled with two-dimensional spectral elements in the remaining two coordinates. The geometry under study has two geometrically homogeneous directions, axial and azimuthal, and we compare statistics from two sets of simulations that employ Fourier expansions for each of these two directions in turn. For the case with Fourier expansions in the azimuthal direction, a cylindrical coordinate system is used.D. M. McIver, H. M. Blackburn and G. J. Natha

Metabolomic profiling and stable isotope labelling of Trichomonas vaginalis and Tritrichomonas foetus reveal major differences in amino acid metabolism including the production of 2-hydroxyisocaproic acid, cystathionine and S-methylcysteine

Trichomonas vaginalis and Tritrichomonas foetus are pathogens that parasitise, respectively, human and bovine urogenital tracts causing disease. Using LC-MS, reference metabolomic profiles were obtained for both species and stable isotope labelling with D-[U-13C6] glucose was used to analyse central carbon metabolism. This facilitated a comparison of the metabolic pathways of T. vaginalis and T. foetus, extending earlier targeted biochemical studies. 43 metabolites, whose identities were confirmed by comparison of their retention times with authentic standards, occurred at more than 3-fold difference in peak intensity between T. vaginalis and T. foetus. 18 metabolites that were removed from or released into the medium during growth also showed more than 3-fold difference between the species. Major differences were observed in cysteine and methionine metabolism in which homocysteine, produced as a bi-product of trans-methylation, is catabolised by methionine γ-lyase in T. vaginalis but converted to cystathionine in T. foetus. Both species synthesise methylthioadenosine by an unusual mechanism, but it is not used as a substrate for methionine recycling. T. vaginalis also produces and exports high levels of S-methylcysteine, whereas only negligible levels were found in T. foetus which maintains significantly higher intracellular levels of cysteine. 13C-labeling confirmed that both cysteine and S-methylcysteine are synthesised by T. vaginalis; S-methylcysteine can be generated by recombinant T. vaginalis cysteine synthase using phosphoserine and methanethiol. T. foetus contained higher levels of ornithine and citrulline than T. vaginalis and exported increased levels of putrescine, suggesting greater flux through the arginine dihydrolase pathway. T. vaginalis produced and exported hydroxy acid derivatives of certain amino acids, particularly 2-hydroxyisocaproic acid derived from leucine, whereas negligible levels of these metabolites occurred in T. foetus

Distinct telomere differences within a reproductively bimodal common lizard population

1. Different strategies of reproductive mode, either oviparity (egg‐laying) or viviparity (live‐bearing), will be associated with a range of other life‐history differences that are expected to affect patterns of ageing and longevity. It is usually difficult to compare the effects of alternative reproductive modes because of evolutionary and ecological divergence. However, the very rare exemplars of reproductive bimodality, in which different modes exist within a single species, offer an opportunity for robust and controlled comparisons. 2. One trait of interest that could be associated with life history, ageing and longevity is the length of the telomeres, which form protective caps at the chromosome ends and are generally considered a good indicator of cellular health. The shortening of these telomeres has been linked to stressful conditions; therefore, it is possible that differing reproductive costs will influence patterns of telomere loss. This is important because a number of studies have linked a shorter telomere length to reduced survival. 3. Here, we have studied maternal and offspring telomere dynamics in the common lizard (Zootoca vivipara). Our study has focused on a population where oviparous and viviparous individuals co‐occur in the same habitat and occasionally interbreed to form admixed individuals. 4. While viviparity confers many advantages for offspring, it might also incur substantial costs for the mother, for example require more energy. Therefore, we predicted that viviparous mothers would have relatively shorter telomeres than oviparous mothers, with admixed mothers having intermediate telomere lengths. There is thought to be a heritable component to telomere length; therefore, we also hypothesized that offspring would follow the same pattern as the mothers. 5. Contrary to our predictions, the viviparous mothers and offspring had the longest telomeres, and the oviparous mothers and offspring had the shortest telomeres. The differing telomere lengths may have evolved as an effect of the life‐history divergence between the reproductive modes, for example due to the increased growth rate that viviparous individuals may undergo to reach a similar size at reproduction

Singlet-Triplet Physics and Shell Filling in Carbon Nanotube Double Quantum Dots

An artifcial two-atomic molecule, also called a double quantum dot (DQD), is an ideal system for exploring few electron physics. Spin-entanglement between just two electrons can be explored in such systems where singlet and triplet states are accessible. These two spin-states can be regarded as the two states in a quantum two-state system, a so-called singlet-triplet qubit. A very attractive material for realizing spin based qubits is the carbon nanotube (CNT), because it is expected to have a very long spin coherence time. Here we show the existence of a gate-tunable singlet-triplet qubit in a CNT DQD. We show that the CNT DQD has clear shell structures of both four and eight electrons, with the singlet-triplet qubit present in the four-electron shells. We furthermore observe inelastic cotunneling via the singlet and triplet states, which we use to probe the splitting between singlet and triplet, in good agreement with theory.Comment: Supplement available at: http://www.fys.ku.dk/~hij/public/singlet-triple_supp.pd

Diagnosing people with dementia using automatic conversation analysis

A recent study using Conversation Analysis (CA) has demonstrated that communication problems may be picked up during conversations between patients and neurologists, and that this can be used to differentiate between patients with (progressive neurodegenerative dementia) ND and those with (nonprogressive) functional memory disorders (FMD). This paper presents a novel automatic method for transcribing such conversations and extracting CA-style features. A range of acoustic, syntactic, semantic and visual features were automatically extracted and used to train a set of classifiers. In a proof-of-principle style study, using data recording during real neurologist-patient consultations, we demonstrate that automatically extracting CA-style features gives a classification accuracy of 95%when using verbatim transcripts. Replacing those transcripts with automatic speech recognition transcripts, we obtain a classification accuracy of 79% which improves to 90% when feature selection is applied. This is a first and encouraging step towards replacing inaccurate, potentially stressful cognitive tests with a test based on monitoring conversation capabilities that could be conducted in e.g. the privacy of the patient’s own home

High-Reynolds-number wall-modelled large eddy simulations of turbulent pipe flows using explicit and implicit subgrid stress treatments within a spectral element solver

We present explicit and implicit large eddy simulations for fully developed turbulent pipe flows using a continuous-Galerkin spectral element solver. On the one hand, the explicit stretched-vortex model (by Misra & Pullin [45] and Chung & Pullin [14]), accounts for an explicit treatment of unresolved stresses and is adapted to the high-order solver. On the other hand, an implicit approach based on a spectral vanishing viscosity technique is implemented. The latter implicit technique is modified to incorporate Chung & Pullin virtual-wall model instead of relying on implicit dissipative mechanisms near walls. This near-wall model is derived by averaging in the wall-normal direction and relying in local inner scaling to treat the time-dependence of the filtered wall-parallel velocity. The model requires space-time varying Dirichlet and Neumann boundary conditions for velocity and pressure respectively. We provide results and comparisons for the explicit and implicit subgrid treatments and show that both provide favourable results for pipe flows at Re_τ = 2×10^3 and Re_τ = 1.8×10^5 in terms of turbulence statistics. Additionally, we conclude that implicit simulations are enhanced when including the wall model and provide the correct statistics near walls

High-Reynolds-number wall-modelled large eddy simulations of turbulent pipe flows using explicit and implicit subgrid stress treatments within a spectral element solver

We present explicit and implicit large eddy simulations for fully developed turbulent pipe flows using a continuous-Galerkin spectral element solver. On the one hand, the explicit stretched-vortex model (by Misra & Pullin [45] and Chung & Pullin [14]), accounts for an explicit treatment of unresolved stresses and is adapted to the high-order solver. On the other hand, an implicit approach based on a spectral vanishing viscosity technique is implemented. The latter implicit technique is modified to incorporate Chung & Pullin virtual-wall model instead of relying on implicit dissipative mechanisms near walls. This near-wall model is derived by averaging in the wall-normal direction and relying in local inner scaling to treat the time-dependence of the filtered wall-parallel velocity. The model requires space-time varying Dirichlet and Neumann boundary conditions for velocity and pressure respectively. We provide results and comparisons for the explicit and implicit subgrid treatments and show that both provide favourable results for pipe flows at Re_τ = 2×10^3 and Re_τ = 1.8×10^5 in terms of turbulence statistics. Additionally, we conclude that implicit simulations are enhanced when including the wall model and provide the correct statistics near walls

Bioelectronic DNA detection of human papillomaviruses using eSensor™: a model system for detection of multiple pathogens

BACKGROUND: We used human papillomaviruses (HPV) as a model system to evaluate the utility of a nucleic acid, hybridization-based bioelectronic DNA detection platform (eSensor™) in identifying multiple pathogens. METHODS: Two chips were spotted with capture probes consisting of DNA oligonucleotide sequences specific for HPV types. Electrically conductive signal probes were synthesized to be complementary to a distinct region of the amplified HPV target DNA. A portion of the HPV L1 region that was amplified by using consensus primers served as target DNA. The amplified target was mixed with a cocktail of signal probes and added to a cartridge containing a DNA chip to allow for hybridization with complementary capture probes. RESULTS: Two bioelectric chips were designed and successfully detected 86% of the HPV types contained in clinical samples. CONCLUSIONS: This model system demonstrates the potential of the eSensor platform for rapid and integrated detection of multiple pathogens