Congenital Goitre in Goats

One full-term, dead foetus was successfully removed from a 5-year old, crossbred black and white goat. The goat was stall-fed with green fodder and it delivered two dead foetuses in the previous pregnancy. The foetus had a large swelling in the cranio-ventral neck region. Upon cutting skin, the swelling revealed extremely enlarged thyroid gland having two asymmetrical lobes with the right lobe was 8.10 x 15.0 cm and the left 5.5 x 8.6 cm in size. The skin was devoid of hair, pale-white and thickened with myxedema. Histologically, the enlarged thyroid consisted of colloid goitre and the lungs were oedematous. This case of congenital goitre was unusual and differed from the reported cases in two aspects viz 1) the two lobes were enlarged but unequal and 2) histologically goitre was colloid instead of usual hyperplastic type

The Politics of the Rule of Law

Article published in the Michigan State International Law Review

The Chaudhry Court : Deconstructing the Judicialization of Politics in Pakistan

The Supreme Court of Pakistan underwent a remarkable transformation in its institutional role and constitutional position during the tenure of the former Chief Justice of Pakistan, Iftikhar Muhammad Chaudhry (2005–2013). This era in Pakistan’s judicial history was also marked by great controversy as the court faced charges that it had engaged in “judicial activism,” acted politically, and violated the constitutionally mandated separation of powers between institutions of the state. This article presents an in-depth analysis of the judicial review actions of the Chaudhry Court and argues that the charge of judicial activism is theoretically unsound and analytically obfuscating. The notion of judicial activism is premised on the existence of artificial distinctions between law, politics and policy and fails to provide a framework for adequately analyzing or evaluating the kind of judicial politics Pakistan has recently experienced. The Supreme Court’s role, like that of any apex court with constitutional and administrative law jurisdiction, has always been deeply and structurally political and will continue to be so in the future. As such, this article focuses on the nature and consequences of the Chaudhry Court’s judicial politics rather than addressing the issue of whether it indulged in politics at all. It analyzes the underlying causes that enabled the court to exercise an expanded judicial function and in doing so engages with the literature on the “judicialization of politics” around the world

Stress induced polarization of immune-neuroendocrine phenotypes in Gallus gallus

Immune-neuroendocrine phenotypes (INPs) stand for population subgroups differing in immune-neuroendocrine interactions. While mammalian INPs have been characterized thoroughly in rats and humans, avian INPs were only recently described in Coturnix coturnix (quail). To assess the scope of this biological phenomenon, herein we characterized INPs in Gallus gallus (a domestic hen strain submitted to a very long history of strong selective breeding pressure) and evaluated whether a social chronic stress challenge modulates the individuals’ interplay affecting the INP subsets and distribution. Evaluating plasmatic basal corticosterone, interferon-γ and interleukin-4 concentrations, innate/acquired leukocyte ratio, PHA-P skin-swelling and induced antibody responses, two opposite INP profiles were found: LEWIS-like (15% of the population) and FISCHER-like (16%) hens. After chronic stress, an increment of about 12% in each polarized INP frequency was found at expenses of a reduction in the number of birds with intermediate responses. Results show that polarized INPs are also a phenomenon occurring in hens. The observed inter-individual variation suggest that, even after a considerable selection process, the population is still well prepared to deal with a variety of immune-neuroendocrine challenges. Stress promoted disruptive effects, leading to a more balanced INPs distribution, which represents a new substrate for challenging situations.Fil: Nazar, Franco Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Estevez, Inma. Centro de Investigación. Neiker - Tecnalia; EspañaFil: Correa, Silvia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Marin, Raul Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentin

Poverty and Its Determinants in Pakistan: Evidence from Pslm 2010-11

This study estimates the poverty in terms of head count ratio, poverty gap and squared poverty gap by using the fresh available PSLM data for the year 2010-11 in Pakistan. This study also finds its economic determinants by estimating multiple OLS regression.The results show that the headcount ratio, poverty gap and squared poverty gap are statistically significant 15.06 %, 2.29 % and 0.55 %, respectively in Pakistan. All of the poverty estimates arestatistically significant almost double in rural areas as compared to urban areas. The comparisons of the poverty estimates of this year with the previous ones of2007-08 at urban, rural and nationallevel show that poverty decreased statistically significantly. Among the provinces it is the highest in Baluchistan and the lowest in Sindh. The comparison of provincial poverty estimates of this year with the same ones of previous year (2007-08) depict that poverty decreased in all of the provinces, but it is statistically significant only in case of Baluchistan.Further the resultsshow that Poverty has statistically significantinverse relationship with education. Households having animals for transportation, owning residential buildings, shops and commercial buildings and living in urban areas have less poverty than those who do not. But it hasstatistically significant positive association with the household size and dependency ratio. The household size is greater in poor families than the rich ones. As far as household head’s employment status, occupation and industry is concerned, it is highest in sharecroppers,elementary occupations, and community, social services. At a policy level, it is suggested that Govt. should focus more on education and generationof employment opportunities. Further it should provide loansto lower income groups on reduced rates for housing facilities andto start their own businesses like shops.Family planning should be encouraged especially in poor families.All such policies should focus more on rural areas of especially Baluchistan and KPK in Pakistan. Keywords: Poverty; Education; Animal for transportation; Household size;  Dependency ratio; Family planning; Residential building;Shops; Pakistan

The Relative Importance of Clinical, Economic, Patient Values and Feasibility Criteria in Cancer Drug Reimbursement in Canada:A Revealed Preferences Analysis of Recommendations of the Pan-Canadian Oncology Drug Review 2011–2017

Background: Most Canadian provinces and territories rely on the pan-Canadian Oncology Drug Review (pCODR) to provide recommendations regarding public reimbursement of cancer drugs. The pCODR review process considers four dimensions of value—clinical benefit, economic evaluation, patient-based values and adoption feasibility—but they do not define weights for individual decision criteria or an acceptable threshold for any of the criteria. Given this implicit review process, it is of interest to understand which factors appear to carry the most weight in pCODR recommendations using a revealed preferences approach. Methods: Using publicly available decision summaries (n = 91) describing submissions and resulting recommendations 2011–2017, we extracted ten attributes that characterized each submission. Using logistic regression, we identified statistically significant attributes and estimated their relative impact in final recommendations. Results: Clinical aspects appear to carry the greatest weight in the decision to reject or not reject, along with aspects of patient value (treatments with no alternatives were less likely to be rejected). Cost effectiveness does not appear to play a role in the initial decision to reject or not reject but is critical in full versus conditional approvals. There is evidence of a maximum acceptable threshold of around $Can140,000 per quality-adjusted life-year (QALY) gained. Conclusion: A set of factors driving pCODR recommendations is identifiable, supporting the consistency of the review process. However, the implicit nature of the review process and the difficulty of extracting and interpreting some of the attribute levels used in the analysis suggests that the process may still lack full transparency

Meta-Analysis of the Incidence of Pharygeocutaneous Fistulas In Laryngectomized Patients

Background: Laryngeal cancer is the seventh most common cancer worldwide, with significant morbidity and mortality. Treatment often involves total laryngectomy, leading to complications such as Pharygeocutaneous fistulas (PCF) in 10-20% of cases. PCFs impede recovery and worsen patient outcomes, with risk factors includingnutritional status, surgical techniques and pre-operative radiotherapy.Methods: A retrospective analysis of 19 studies including over 5000 patients was conducted to evaluate the incidence of PCF in laryngectomized patients. The study focused on laryngectomies performed for laryngeal carcinoma. Examining risk factors such as age, nutritional status and deficiencies, radiotherapy and surgical techniques. Studies unrelated to oncological treatment or those published before 2000 were excluded.Results: No significant difference in the rate of PCF was found between oral feeding and feeding via a Nasogastric tube (NGT). Hypoalbuminemia was a notable risk factor in the development of PCF. Advanced tumour stages (T3 and T4) were linked to a higher incidence of PCF, though statical significance varied. Continuous suturing and mechanical sutures showed reduced PCF risk compared to interrupted and manual sutures.Conclusion: PCF are the most common complication post-laryngectomy, with factors like hypoalbuminemia, low haemoglobin and preoperative radiotherapy increasing the risk. Pre-operative optimization of the nutritional and haematological status is recommended to lower PCF incidence and improve patient outcomes and quality of life