Automated mass spectrometer/analysis system: A concept

System performs rapid multiple analyses of entire compound classes or individual compounds on small amounts of sample and reagent. Method will allow screening of large populations for metabolic disorders and establishment of effective-but-safe levels of therapeutic drugs in body fluids and tissues

The effect of stellar limb darkening values on the accuracy of the planet radii derived from photometric transit observations

We study how the precision of the exoplanet radius determination is affected by our present knowledge of limb darkening in two cases: when we fix the limb darkening coefficients and when we adjust them. We also investigate the effects of spots in one-colour photometry. We study the effect of limb darkening on the planetary radius determination both via analytical expressions and by numerical experiments. We also compare some of the existing limb darkening tables. When stellar spots affect the fit, we replace the limb darkening coefficients, calculated for the unspotted cases, with effective limb darkening coefficients to describe the effect of the spots. There are two important cases. (1) When one fixes the limb darkening values according to some theoretical predictions, the inconsistencies of the tables do not allow us to reach accuracy in the planetary radius of better than 1-10% (depending on the impact parameter) if the host star's surface effective temperature is higher than 5000 K. Below 5000 K the radius ratio determination may contain even 20% error. (2) When one allows adjustment of the limb darkening coefficients, the a/Rs ratio, the planet-to-stellar radius ratio, and the impact parameter can be determined with sufficient accuracy (<1%), if the signal-to-noise ratio is high enough. However, the presence of stellar spots and faculae can destroy the agreement between the limb darkening tables and the fitted limb darkening coefficients, but this does not affect the precision of the planet radius determination. We also find that it is necessary to fit the contamination factor, too. We conclude that the present inconsistencies of theoretical stellar limb darkening tables suggests one should not fix the limb darkening coefficients. When one allows them to be adjusted, then the planet radius, impact parameter, and the a/Rs can be obtained with the required precision.Comment: Astronomy & Astrophysics Vol. 549, A9 (2013) - 11 page

Sectioning of the inferior dental nerve in rats

KIMTS2016.http://journals.sagepub.com/doi/abs/10.1177/0022034569048005670

The influence of alkaline phosphatase, calcium glycerophosphate and alginate on the repair of bone

P

Monastic retreat and pastoral care in the Dutch Reformed tradition

Of late, there has been a growing interest in retreat among clergy and members of congregations in the Dutch Reformed tradition in South Africa. The article investigates the relevance of the monastic traditions for this growing interest in Reformed circles. It focuses on aspects of retreat such as the role of holy places in the monastic traditions (e.g., monasteries, cathedrals, retreat centers) and the experience of silence, solitude, regeneration, divine presence and spiritual formation. Proceeding from an epistemological reflection on the subject as described in a previous article, the aim of this article is to explore the “action of retreat” as a narrative research journey and pilgrimage in order to investigate the relevance of the Benedictine, Franciscan and Taizé monastic-mystic traditions (seen as an associative/mystic spirituality) for retreat in the Dutch Reformed tradition (which is seen as a disassociative/rational/ dogmatic spirituality)

Phase I of the DiaVACCS screening trial: Study design, methods, population demographics and baseline results

Background. Human papillomavirus (HPV)-based primary screening guidelines are based on screening test performance and prevalence data generated in high-resource areas with low HIV infection rates. There is an urgent need for local data on infection and disease prevalence, as well as screening test performance, among both HIV-positive and HIV-negative South African (SA) women, in order to inform updated screening guidelines. Objectives. This study describes the baseline characteristics of participants in the cross-sectional phase of the multicentric DIAgnosis in Vaccine And Cervical Cancer Screen (DiaVACCS) screening trial. The objective was to determine the prevalence of positive screening and pre-invasive disease using different tests and strategies in the SA HIV-positive and HIV-negative population.Methods. A total of 1  104 women aged 25 - 65 years and eligible for screening were included, 465 HIV positive and 639 HIV negative. Visual inspection and molecular and cytological screening tests were done on self-sampled and healthcare worker-collected specimens. All participants who screened positive and 49.1% of those who screened negative were invited for colposcopy and biopsy, and those qualifying for treatment were recalled for large loop excision of the transformation zone as part of the trial. The worst histology result for each participant was used, and for untested women, multiple imputation was used to estimate verification biasadjusted histology values.Results. Visual inspection was positive in 50.4% of HIV-positive v. 20.9% of HIV-negative women, cytology (atypical squamous cells of undetermined significance) in 39.9% v. 17.0%, and high-risk HPV DNA in 41.2% v. 19.6%. Overall, high-grade squamous intraepithelial lesion-positive cytology peaked in the age group 30 - 39 years at 16.7%. After adjustment for verification bias, histological diagnosis of cervical intraepithelial neoplasia (CIN)2+ was suspected in 44.7% v. 23.5% and CIN3+ in 23.3% v. 10.2% of HIV-positive and negative women, respectively. Invasive cancer was diagnosed in 15 women (1.95% of histological studies performed), and verification bias adjustment suggested 20 cases (1.8% of the study population).Conclusion. The baseline findings from the DiaVACCS trial confirm a high prevalence of HPV-related cervical pathology in the SA HIV-negative screening population, showing a clear need to reach these women with a screening programme. Among HIV-positive women, prevalence values were almost doubled. The prevalence of existing invasive cervical cancer was 1 - 2% of all women. Further analysis of the performance of single and multiple screening tests between the two subgroups will contribute to the choice of the most effective strategies to identify women at risk of developing invasive cancer

Induced exchange of fluids in the treatment of post-traumatic infective lesions

KI

Quasinormal Modes, the Area Spectrum, and Black Hole Entropy

The results of canonical quantum gravity concerning geometric operators and black hole entropy are beset by an ambiguity labelled by the Immirzi parameter. We use a result from classical gravity concerning the quasinormal mode spectrum of a black hole to fix this parameter in a new way. As a result we arrive at the Bekenstein - Hawking expression of $A/4 l_P^2$ for the entropy of a black hole and in addition see an indication that the appropriate gauge group of quantum gravity is SO(3) and not its covering group SU(2).Comment: 4 pages, 2 figure