An isotopic effect in phi photoproduction at a few GeV

A distinct isotopic effect in phi photoproduction at 2-5 GeV region is identified by examining the production amplitudes due to Pomeron-exchange and meson-exchange mechanisms. This effect is mainly caused by the pi-eta interference constrained by SU(3) symmetry and the isotopic structure of the gamma NN coupling in the direct phi-radiation amplitude. It can be tested experimentally by measuring differences in the polarization observables between the gamma-p and gamma-n reactions.Comment: 11 pages, 6 figure

Leptoquark pair production at the Fermilab Tevatron: Signal and backgrounds

We perform a Monte-Carlo simulation of scalar leptoquark pair production at the Tevatron (energy =1.8 TeV and luminosity =100 pb^{-1}) with ISAJET. We also investigate the dominant sources of Standard Model background: Z*jj, ZZ production and heavy quark top-antitop. We find that the top-antitop background is the most important except near the Z pole where the Z*jj background is peaked. We also evaluate the signal-to-background ratio and find a discovery reach of 130 GeV (170 GeV) for a branching ratio of B(LQ-> eq)=0.5 (B=1).Comment: 8 pages, 6 figures, latex (revtex

Scalar and Vector Leptoquark Pair Production at Hadron Colliders: Signal and Backgrounds

We perform a systematic analysis of scalar and vector leptoquark pair production at the Fermilab Tevatron and at the CERN LHC. We evaluate signal expectations and background levels for the processes pp (p ppar) -> 2 jets + e^{+} + e^{-} and 2 jets + e + missing p_T. The Monte Carlo event generator ISAJET is used to simulate the experimental conditions at the current (Sqrt{s}=1.8 TeV, Luminosity=100 pb^{-1}) and upgraded (Luminosity=100 pb^{-1}) Tevatron as well as the LHC (Sqrt{s}=14 TeV, Luminosity=10 fb^{-1}). Depending on the luminosity, and assuming a branching ratio B(LQ -> eq)=0.5, we find a discovery reach up to 170 (255) GeV for scalar leptoquarks at the current (upgraded) Tevatron. Similarly, we find vector leptoquarks to be detectable at masses below 300 (400) GeV depending on the coupling. At the LHC, the discovery reach is enhanced to 1 TeV for scalar leptoquarks and to 1.5 TeV for vectors.Comment: 15 pages (REVTEX), 12 figures, submitted to Phys. Rev.

ПЕДІАТРИЧНА ОСВІТА УКРАЇНИ У ХХІ СТОРІЧЧІ: СУЧАСНІ ВИКЛИКИ ТА ПРОБЛЕМИ МАЙБУТНЬОГО

The aim of the work – to evaluate the state of development of pediatric education in Ukraine in the beginning of the 21st century, staffing of the branch in the field of pediatrics and to develop a plan of measures to overcome the crisis phenomena in pediatric health care. The main body. The article presents data on the development of pediatric education in the early 21st century after the restoration of the educational-scientific specialty “Pediatrics” in 2017. The development of up-to-date standards for the training of pediatric doctors, based on the acquisition of future master’s degrees in pediatrics, general and professional competencies and necessary practical skills is highlighted. The current problems in the provision of pediatric health care facilities are emphasized. Conclusion. A list of measures at the sectoral and national level has been developed to restore the necessary training рediatricians for childrenʼs health care of the country and to ensure the proper methodological provision of the educational process, which may cause difficulties in providing children with quality medical care in the future.Мета роботи – оцінити стан розвитку педіатричної освіти в Україні на початку ХХІ сторіччя, кадрове забезпечення галузі за спеціальністю «Педіатрія» та розробити план заходів щодо подолання кризових явищ у педіатричній охороні здоровʼя. Основна частина. У статті наведено дані щодо розвитку педіатричної освіти на початку ХХІ сторіччя після відновлення освітньо-наукової спеціальності «Педіатрія» у 2017 р. Висвітлено розробку сучасних стандартів підготовки дитячих лікарів, що базуються на набутті майбутніми магістрами педіатрії загальних та фахових компетенцій і необхідних практичних навичок. Наголошено на теперішніх проблемах у кадровому забезпеченні педіатричних закладів охорони здоровʼя, що може викликати складнощі у забезпеченні дітей якісною медичною допомогою у майбутньому. Висновок. Розроблений перелік заходів на галузевому та загальнодержавному рівні щодо відновлення необхідних для країни обсягів підготовки дитячих лікарів та забезпечення належного методичного забезпечення навчального процесу

Myocardial Hibernation in Patients with Arterial Hypertension and Ischemic Heart Disease as a Cause of Heart Failure

Introduction. Myocardial hibernation refers to “new ischemic syndromes,” which in recent years have increasingly attracted the attention of cardiologists and cardiac surgeons. Hibernation includes a number of adaptive responses: inhibition of metabolic processes to more complex and lengthy pathophysiological changes that lead to myocardial contractile weakness, and their degeneration of cardiomyocytes and their apoptosis. Aim. To find out the pathophysiological mechanisms of occurrence and ultrastructural signs of cardiomyocyte hibernation in patients with arterial hypertension (AH) and myocardial infarction (MI), as well as the role of hibernation in the occurrence of heart failure (HF). To determine the dependence of segmental disorders of the left ventricular myocardial contractility (hypokinesia, akinesia, dyskinesia) on the presence of hybridized cardiomyocytes and to reveal the duration of their life. Materials and methods. For 36 patients with hypertension and coronary artery disease were examined, were examined the ultrastructure of myocardial biopsy material (n = 10) obtained during coronary artery bypass graft (CABG) and aneurysmectomy, as well as express neoplastic lesions (n​​= 26) in those who died of heart attack. Myocardial biopsies were obtained during the execution of the CABG for angina pectoris (n = 10) or ventriculoplasty in combination with CABG (n = 6). Ultra-structured study of 10 myocardial biopsies during CABG and ventriculoplasty, as well as 26 express-necropsies of the myocardium of those died due to the MI who were ill with hypertension were made. Results. It has been determined that hypertrophy and cardiomyocyte hybridization correlate with the severity of hypertension, MI, besides necrosis, causes stunning, hypertension, apoptosis, and necrosis of cardiomyocytes, mainly in the parainfarction and intact regions of the left venticle. The hepatized cardiomyocytes (irreversibly altered, hybridized cardiomyocytes containing α-glucogens) were first detected. The correlation between the percentage of remodulated cells (from 50.0 to > 75.0%) and the emergence of segmental lesions of the contractility of left ventricle (hypo-, aki-, dyskinesia), which leads to acute and chronic HF was found. Conclusions. Myocardial hibernation is a clinically important syndrome, which is often accompanied, under certain circumstances, by the transient left ventricle dysfunction. It is important to consider it in clinical practice, since hibernation is present in patients with almost all forms of coronary heart disease and requires both medical and surgical treatment

Gastric cancer, version 2.2013: featured updates to the NCCN Guidelines

The NCCN Clinical Practice Guidelines in Oncology for Gastric Cancer provide evidence- and consensus-based recommendations for a multidisciplinary approach for the management of patients with gastric cancer. For patients with resectable locoregional cancer, the guidelines recommend gastrectomy with a D1+ or a modified D2 lymph node dissection (performed by experienced surgeons in high-volume centers). Postoperative chemoradiation is the preferred option after complete gastric resection for patients with T3-T4 tumors and node-positive T1-T2 tumors. Postoperative chemotherapy is included as an option after a modified D2 lymph node dissection for this group of patients. Trastuzumab with chemotherapy is recommended as first-line therapy for patients with HER2-positive advanced or metastatic cancer, confirmed by immunohistochemistry and, if needed, by fluorescence in situ hybridization for IHC 2+

Esophageal and esophagogastric junction cancers, version 1.2015

Esophageal cancer is the sixth most common cause of cancer deaths worldwide. Adenocarcinoma is more common in North America and Western European countries, originating mostly in the lower third of the esophagus, which often involves the esophagogastric junction (EGJ). Recent randomized trials have shown that the addition of preoperative chemoradiation or perioperative chemotherapy to surgery significantly improves survival in patients with resectable cancer. Targeted therapies with trastuzumab and ramucirumab have produced encouraging results in the treatment of advanced or metastatic EGJ adenocarcinomas. Multidisciplinary team management is essential for patients with esophageal and EGJ cancers. This portion of the NCCN Guidelines for Esophageal and EGJ Cancers discusses management of locally advanced adenocarcinoma of the esophagus and EGJ

Assessing the cardiology community position on transradial intervention and the use of bivalirudin in patients with acute coronary syndrome undergoing invasive management: results of an EAPCI survey.

AIMS: Our aim was to report on a survey initiated by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) collecting the opinion of the cardiology community on the invasive management of acute coronary syndrome (ACS), before and after the MATRIX trial presentation at the American College of Cardiology (ACC) 2015 Scientific Sessions. METHODS AND RESULTS: A web-based survey was distributed to all individuals registered on the EuroIntervention mailing list (n=15,200). A total of 572 and 763 physicians responded to the pre- and post-ACC survey, respectively. The radial approach emerged as the preferable access site for ACS patients undergoing invasive management with roughly every other responder interpreting the evidence for mortality benefit as definitive and calling for a guidelines upgrade to class I. The most frequently preferred anticoagulant in ACS patients remains unfractionated heparin (UFH), due to higher costs and greater perceived thrombotic risks associated with bivalirudin. However, more than a quarter of participants declared the use of bivalirudin would increase after MATRIX. CONCLUSIONS: The MATRIX trial reinforced the evidence for a causal association between bleeding and mortality and triggered consensus on the superiority of the radial versus femoral approach. The belief that bivalirudin mitigates bleeding risk is common, but UFH still remains the preferred anticoagulant based on lower costs and thrombotic risks