An integrated study of earth resources in the State of California based on ERTS-1 and supporting aircraft data, volume 1

There are no author-identified significant results in this report

Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease.

Cardiovascular dysautonomia as well as the deterioration of circadian rhythms are among the earliest detectable pathophysiological changes in individuals with Huntington's disease (HD). Preclinical research requires mouse models that recapitulate disease symptoms and the Q175 knock-in model offers a number of advantages but potential autonomic dysfunction has not been explored. In this study, we sought to test the dual hypotheses that cardiovascular dysautonomia can be detected early in disease progression in the Q175 model and that this dysfunction varies with the daily cycle. Using radiotelemetry implants, we observed a significant reduction in the diurnal and circadian activity rhythms in the Q175 mutants at the youngest ages. By middle age, the autonomically driven rhythms in core body temperature were highly compromised, and the Q175 mutants exhibited striking episodes of hypothermia that increased in frequency with mutant huntingtin gene dosage. In addition, Q175 mutants showed higher resting heart rate (HR) during sleep and greatly reduced correlation between activity and HR HR variability was reduced in the mutants in both time and frequency domains, providing more evidence of autonomic dysfunction. Measurement of the baroreceptor reflex revealed that the Q175 mutant could not appropriately increase HR in response to a pharmacologically induced decrease in blood pressure. Echocardiograms showed reduced ventricular mass and ejection fraction in mutant hearts. Finally, cardiac histopathology revealed localized points of fibrosis resembling those caused by myocardial infarction. Thus, the Q175 mouse model of HD exhibits cardiovascular dysautonomia similar to that seen in HD patients with prominent sympathetic dysfunction during the resting phase of the activity rhythm

Granitoid rocks and associated coper skarn, Whycocomagh Mountain, Cape Breton Island, Nova Scotia

Mineralized (Fe-Cu-W-Mo) skarn in the Whycocomagh Mountain area is associated with a small pluton of Devonian (402±20 Ma) age, which intruded predominantly metasedimentary rocks of the Hadrynian George River Group. The pluton consists largely of granite porphyry with a marginal granodiorite to diorite zone, and minor porphyritlc granodiorite to monzodiorite dykes and pegmatite. The suite is calc-alkalic with I-type characteristics. Although weakly mineralized, the Whycocomagh Mountain pluton has features typical of plutons associated with porphyry-type Cu-Mo deposits. Calc-silicate rocks derived from marbles of the George River Group are the chief hosts for magnetlte ± chalcopyrlte ± scheelite ± molybdenite ± pyrite which occur in veinlets along fractures and as disseminated grains In adjacent alteration envelopes. Characteristics of the pluton and the skarn minerals suggest that the deposit is a copper skarn. RÉSUMÉ Un skarn minéralise (Fe-Cu-W-Mo), situe dans la région de la montagne Whycocomagh, est associé à une petite intrusion ignée d'âge Dévonien (402±20 m.a.) qui pénétre des roches, principalement des métasédiments, du groupe George River (Hadrynien). Le pluton consiste surtout en un granite porphyrique accompagne d'une zone marginale (granodiorite à diorite), de dykes mineurs (granodiorite à monzodiorite porphyrique) et de pegmatite. L'ensemble est calco-alcalln et de "type 1". Blen que faiblement minéralise, le pluton Whycocomagh Mountain possède lea caractérlstiques typiques des plutons associés aux dépôts porphyrlques de type Cu-Mo. Les calco-sflicates dérives des marbres du groupe George River sont les notes principaux du cortege for magnétite ± chalcopyrlte ± scheelite ± molybdenite ± pyrite que L’on retrouve dans des veinules le long des fractures et disséminés dans les enveloppes d'alteratlon volsines. Les caractérlstiques du pluton ainsi que la minéralogle du skarn font croire qu'il s'agit d'un dépôt de skarn cuprifère. (Tradult par le Journal

Remote sensing research for agricultural applications

Materials and methods used to characterize selected soil properties and agricultural crops in San Joaquin County, California are described. Results show that: (1) the location and widths of TM bands are suitable for detecting differences in selected soil properties; (2) the number of TM spectral bands allows the quantification of soil spectral curve form and magnitude; and (3) the spatial and geometric quality of TM data allows for the discrimination and quantification of within field variability of soil properties. The design of the LANDSAT based multiple crop acreage estimation experiment for the Idaho Department of Water Resources is described including the use of U.C. Berkeley's Survey Modeling Planning Model. Progress made on Peditor software development on MIDAS, and cooperative computing using local and remote systems is reported as well as development of MIDAS microcomputer systems

Environment-Induced Changes in Selective Constraints on Social Learning During the Peopling of the Americas

The weaponry technology associated with Clovis and related Early Paleoindians represents the earliest well-defined evidence of humans in Pleistocene North America. We assess the technological diversity of these fluted stone points found at archaeological sites in the western and eastern halves of North America by employing statistical tools used in the quantification of ecological biodiversity. Our results demonstrate that the earliest hunters in the environmentally heterogeneous East used a more diverse set of points than those in the environmentally homogenous West. This and other evidence shows that environmental heterogeneity in the East promoted the relaxation of selective constraints on social learning and increased experimentation with point designs

Consumption of resistant starch decreases postprandial lipogenesis in white adipose tissue of the rat

Chronic consumption of diets high in resistant starch (RS) leads to reduced fat cell size compared to diets high in digestible starch (DS) in rats and increases total and meal fat oxidation in humans. The aim of the present study was to examine the rate of lipogenesis in key lipogenic organs following a high RS or DS meal. Following an overnight fast, male Wistar rats ingested a meal with an RS content of 2% or 30% of total carbohydrate and were then administered an i.p bolus of 50 μCi (3)H(2)O either immediately or 1 hour post-meal. One hour following tracer administration, rats were sacrificed, a blood sample collected, and the liver, white adipose tissue (WAT), and gastrocnemius muscle excised and frozen until assayed for total (3)H-lipid and (3)H-glycogen content. Plasma triglyceride and NEFA concentrations and (3)H-glycogen content did not differ between groups. In all tissues, except the liver, there was a trend for the rate of lipogenesis to be higher in the DS group than the RS group which reached significance only in WAT at 1 h (p < 0.01). On a whole body level, this attenuation of fat deposition in WAT in response to a RS diet could be significant for the prevention of weight gain in the long-term

Charge Transfer from Regularized Symmetry-Adapted Perturbation Theory

16 pages, 16 figure