11,707 research outputs found
Definition, analysis and development of an optical data distribution network for integrated avionics and control systems. Part 2: Component development and system integration
Fiber optic transmission is emerging as an attractive concept in data distribution onboard civil aircraft. Development of an Optical Data Distribution Network for Integrated Avionics and Control Systems for commercial aircraft will provide a data distribution network that gives freedom from EMI-RFI and ground loop problems, eliminates crosstalk and short circuits, provides protection and immunity from lightning induced transients and give a large bandwidth data transmission capability. In addition there is a potential for significantly reducing the weight and increasing the reliability over conventional data distribution networks. Wavelength Division Multiplexing (WDM) is a candidate method for data communication between the various avionic subsystems. With WDM all systems could conceptually communicate with each other without time sharing and requiring complicated coding schemes for each computer and subsystem to recognize a message. However, the state of the art of optical technology limits the application of fiber optics in advanced integrated avionics and control systems. Therefore, it is necessary to address the architecture for a fiber optics data distribution system for integrated avionics and control systems as well as develop prototype components and systems
Electron microscopic visualization of tRNA genes with ferritin-avidin: biotin labels
A method is described for indirect electron microscopic visualization and mapping of tRNA and other short transcripts hybridized to DNA. This method depends upon the attachment of the electron-dense protein ferritin to the RNA, the binding being mediated by the remarkably strong association of the egg white protein avidin with biotin. Biotin is covalently attached to the 3' end of tRNA using an NH2 (CH2) 5NH2 bridge. The tRNA-biotin adduct is hybridized to complementcrry DNA sequences present in a single stranded nonhomology loop of a DNA:DNA heteroduplex. Avidin, covalently crosslinked to ferritin is mixed with the heteroduplex and becomes bound to the hybridized tRNA-biotin. Observation of the DNA:RNA-biotin:avidin-ferritin complex by electron microsdopy specifically and accurately reveals the position of the tRNA gene, with a frequency of labeling of approximately 50%
A short note on the presence of spurious states in finite basis approximations
The genesis of spurious solutions in finite basis approximations to operators
which possess a continuum and a point spectrum is discussed and a simple
solution for identifying these solutions is suggested
Second Cluster Integral and Excluded Volume Effects for the Pion Gas
The quantum mechanical formula for Mayer's second cluster integral for the
gas of relativistic particles with hard-core interaction is derived. The proper
pion volume calculated with quantum mechanical formula is found to be an order
of magnitude larger than its classical evaluation.
The second cluster integral for the pion gas is calculated in quantum
mechanical approach with account for both attractive and hard-core repulsive
interactions. It is shown that, in the second cluster approximation, the
repulsive pion-pion-interactions as well as the finite width of resonances give
important but almost canceling contributions. In contrast, an appreciable
deviation from the ideal gas of pions and pion resonances is observed beyond
the second cluster approximation in the framework of the Van der Waals
excluded-volume model.Comment: 29 pages, Latex, 9 PS-figure
Temperature variation of total hemispherical emissivity of stainless steel AISI 304
[[abstract]]Numerical values of the total hemispherical emissivities Eh of a mechanically polished surface and an electropolished surface of a sample of stainless steel, type AISI 304, have been determined experimentally for the first time in the temperature range 340-1100 K. An absolute method incorporating the transient calorimetric principle was used in these measurements. It is found that the 4Eh values obtained are only very slightly different from those predicted by a classical expression for total hemispherical emissivity developed by Davisson and Weeks.[[notice]]èŁæŁćźçą[[booktype]]çŽ
In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.
BackgroundCruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease. As a proof-of-concept, K11777, a potent inhibitor of cruzain, was found to effectively eliminate T. cruzi infection and is currently a clinical candidate for treatment of Chagas' disease.Methodology/principal findingsWRR-483, an analog of K11777, was synthesized and evaluated as an inhibitor of cruzain and against T. cruzi proliferation in cell culture. This compound demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. Furthermore, WRR-483 also eradicates parasite infection in a mouse model of acute Chagas' disease. To determine the atomic-level details of the inhibitor interacting with cruzain, a 1.5 A crystal structure of the protease in complex with WRR-483 was solved. The structure illustrates that WRR-483 binds covalently to the active site cysteine of the protease in a similar manner as other vinyl sulfone-based inhibitors. Details of the critical interactions within the specificity binding pocket are also reported.ConclusionsWe demonstrate that WRR-483 is an effective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. Crystallographic evidence confirms that the mode of action is by targeting the active site of cruzain. Taken together, these results suggest that WRR-483 has potential to be developed as a treatment for Chagas' disease
Van der Waals Excluded Volume Model of Multicomponent Hadron Gas
A generalization of the Van der Waals excluded volume procedure for the
multicomponent hadron gas is proposed. The derivation is based on the grand
canonical partition function for the system of particles of several species
interacting by hard core potentials. The obtained formulae for thermodynamical
quantities are consistent with underlying principles of statistical mechanics
as well as with thermodynamical identities. The model can be applied to the
analysis of experimental data for particle number ratios in relativistic
nucleus-nucleus collisions.Comment: 8 page
Breakdown of Conformal Invariance at Strongly Random Critical Points
We consider the breakdown of conformal and scale invariance in random systems
with strongly random critical points. Extending previous results on
one-dimensional systems, we provide an example of a three-dimensional system
which has a strongly random critical point. The average correlation functions
of this system demonstrate a breakdown of conformal invariance, while the
typical correlation functions demonstrate a breakdown of scale invariance. The
breakdown of conformal invariance is due to the vanishing of the correlation
functions at the infinite disorder fixed point, causing the critical
correlation functions to be controlled by a dangerously irrelevant operator
describing the approach to the fixed point. We relate the computation of
average correlation functions to a problem of persistence in the RG flow.Comment: 9 page
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