Patients' preferences for the management of non-metastatic prostate cancer: discrete choice experiment

Objective To establish which attributes of conservative treatments for prostate cancer are most important to men. Design Discrete choice experiment. Setting Two London hospitals. Participants 129 men with non-metastatic prostate cancer, mean age 70 years; 69 of 118 (58%) with T stage 1 or 2 cancer at diagnosis. Main outcome measures Men's preferences for, and trade-offs between, the attributes of diarrhoea, hot flushes, ability to maintain an erection, breast swelling or tenderness, physical energy, sex drive, life expectancy, and out of pocket expenses. Results The men's responses to changes in attributes were all statistically significant. When asked to assume a starting life expectancy of five years, the men were willing to make trade-offs between life expectancy and side effects. On average, they were most willing to give up life expectancy to avoid limitations in physical energy (mean three months) and least willing to trade life expectancy to avoid hot flushes (mean 0.6 months to move from a moderate to mild level or from mild to none). Conclusions Men with prostate cancer are willing to participate in a relatively complex exercise that weighs up the advantages and disadvantages of various conservative treatments for their condition. They were willing to trade off some life expectancy to be relieved of the burden of troublesome side effects such as limitations in physical energy

Does Eccentric Hamstring Training Improve Speed and Jump Performance in Team Sports: A Systematic Review

Eccentric strength is thought to be a key component of fitness for sports requiring rapid movements such as sprinting and jumping. As a result, eccentric training forms part of strength and conditioning programmes in these sports (Krommes et al., 2017, Biomed Central Research Notes, 10(1), 669). However, the association between improvements in eccentric strength and athletic performance remains unclear. The aim of this systematic review was to determine the effect of improvements in eccentric strength on sprint and jump performance. Online databases including SPORTDiscus, CINAHL, MEDLINE, PubMed and ScienceDirect were searched (June 2017) with a date restriction (2007 – 2017) to obtain relevant articles. Search terms included eccentric hamstring training “AND” performance, speed, strength and jump performance. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to report the screening of articles. The Physiotherapy Evidence Database (PEDro) Scale was used to assess the methodological quality of each included article. A total of 8,613 articles were returned from the search. After screening the title and abstracts, 8,591 articles were excluded. Out of the remaining 25 articles, 17 were excluded after a review of full texts. A further 3 articles were identified from manually searching reference lists from which 1 was included. A total of 8 studies were included in the review. The studies included in this review were of poor methodological quality (PEDro 4.1/10). Overall, significant improvements were found in speed and jump performance for the eccentric training groups compared to the control groups. Only 2 of the studies measured strength pre and post intervention. There is weak evidence that eccentric training is effective in promoting improvements in speed and jump performance. Further high quality randomised controlled trials are needed to support the use of eccentric training to improve speed and jump performance

Prospects of accelerator and reactor neutrino oscillation experiments for the coming ten years

We analyze the physics potential of long baseline neutrino oscillation experiments planned for the coming ten years, where the main focus is the sensitivity limit to the small mixing angle $\theta_{13}$. The discussed experiments include the conventional beam experiments MINOS, ICARUS, and OPERA, which are under construction, the planned superbeam experiments J-PARC to Super-Kamiokande and NuMI off-axis, as well as new reactor experiments with near and far detectors, represented by the Double-Chooz project. We perform a complete numerical simulation including systematics, correlations, and degeneracies on an equal footing for all experiments using the GLoBES software. After discussing the improvement of our knowledge on the atmospheric parameters $\theta_{23}$ and $\Delta m^2_{31}$ by these experiments, we investigate the potential to determine $\theta_{13}$ within the next ten years in detail. Furthermore, we show that under optimistic assumptions and for $\theta_{13}$ close to the current bound, even the next generation of experiments might provide some information on the Dirac CP phase and the type of the neutrino mass hierarchy.Comment: 38 pages, 13 figures, Eqs. (1) and (5) corrected, small corrections in Figs. 8, 9, and Tab. 4, discussion improved, ref. added, version to appear in PRD, high resolution figures are available at http://www.sns.ias.edu/~winter/figs0403068.htm

Production of Eta Mesons in Proton-Proton Collisions Close to Threshold

A brief experimental overview on the close-to-threshold eta meson production in proton-proton interactions is presented and the available observables in measurements with unpolarized and polarized beam and target are discussed.Comment: 4 pages; Presented at Meson 2004: 8th International Workshop on Meson Production, Properties and Interaction, Krakow, Poland, 4-8 June 2004; Submitted to International Journal of Modern Physics

Impurity intrusion in radio-frequency micro-plasma jets operated in ambient air

Space and time resolved concentrations of helium metastable atoms in an atmospheric pressure radio-frequency micro-plasma jet were measured using tunable diode laser absorption spectroscopy. Spatial profiles as well as lifetime measurements show significant influences of air entering the discharge from the front nozzle and of impurities originating from the gas supply system. Quenching of metastables was used to deduce quantitative concentrations of intruding impurities. The impurity profile along the jet axis was determined from optical emission spectroscopy as well as their dependance on the feed gas flow through the jet.Comment: Journal of Physics D: Applied Physics (accepted), 6 page

Effect of Structure on the Spin Switching and Magnetic Bistability of Solid-State Aryl Dicyanomethyl Monoradicals and Diradicals

Stable organic radicals with switchable spin states have applications in medicine, biology, and material science. An emerging class of such spin-switchable radicals is based on dicyanomethyl radicals, which are typically thermally and air-stable species that form weakly bonded (closed-shell singlet) dimers at a lower temperature that rupture into electron paramagnetic resonance-active diradicals at a higher temperature. However, thus far, the study of these dicyanomethyl radicals has focused on their solution-phase behavior. An understanding of how chemical structure affects the solid-state spin switching behavior for these radicals is unknown. Here, we examine the solid-state spin crossover behavior of 6 monoradicals and 10 tethered diradicals and demonstrate that these species also undergo spin switching in the solid state. We find that the susceptibility for solid-state spin switching for the intermolecular dimers is weakly correlated to the solution-phase Gibbs free energies of dimerization, but no apparent correlations are seen between the solution-state free energies for the intramolecular dimerization and the solid-state behavior. Furthermore, intramolecular diradical dimers have greatly enhanced temperature-responsive behavior compared to their intermolecular counterparts. Crystalline and amorphous powders of the same radicals feature similar spin switching behavior, but the crystalline materials have slower bond-rupture kinetics at higher temperatures, suggesting that solid-state packing effects are an important kinetic consideration. An interesting feature of these systems is that, upon cooling down to room temperature after heating, some radicals remain trapped in the solids, indicating magnetic bistability, while others partially or fully return to the diamagnetic dimers. This work provides insights into how chemical structure affects spin crossover in the solid state for this new class of air-stable radicals, the knowledge of importance for the construction of dynamically responsive solid-state materials, and organic spin crossover polymers