2,667 research outputs found
The Extrajudicial Voice
Judges communicate outside of the courtroom on a regular basis. They give speeches at universities and to societies; appear before select committees; write for a range of publications; and engage in both media and outreach activities. Existing literature has charted the value and perils of such extrajudicial communication. This paper contributes an explanation of what motivates judges towards such communication, and what shapes their discourse. The work draws on 13 semi-structured interviews with senior serving and recently judges, along with an extensive range of examples of judicial speech beyond the bench. It argues that extrajudicial communication is shaped by a shared conception amongst the judicial community of what is appropriate. This conception of propriety is principally motivated by a communal pursuit of sustaining public confidence in the judicial office. The conception also informs the limits of appropriate discourse and establishes the ramifications for breach
Optical carrier wave shocking: detection and dispersion
Carrier wave shocking is studied using the Pseudo-Spectral Spatial Domain
(PSSD) technique. We describe the shock detection diagnostics necessary for
this numerical study, and verify them against theoretical shocking predictions
for the dispersionless case. These predictions show Carrier Envelope Phase
(CEP) and pulse bandwidth sensitivity in the single-cycle regime. The flexible
dispersion management offered by PSSD enables us to independently control the
linear and nonlinear dispersion. Customized dispersion profiles allow us to
analyze the development of both carrier self-steepening and shocks. The results
exhibit a marked asymmetry between normal and anomalous dispersion, both in the
limits of the shocking regime and in the (near) shocked pulse waveforms.
Combining these insights, we offer some suggestions on how carrier shocking (or
at least extreme self-steepening) might be realised experimentally.Comment: 9 page
Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour
The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in mammals in vivo. We explored the role of strumpellin, which has previously been linked to hereditary spastic paraplegia, in the mouse melanocytic lineage. Strumpellin knockout in melanocytes revealed abnormal endocytic vesicle morphology but no impairment of migration in vitro or in vivo and no change in coat colour. Unexpectedly, WASH and filamentous actin could still localize to vesicles in the absence of strumpellin, although the shape and size of vesicles was altered. Blue native PAGE revealed the presence of two distinct WASH complexes, even in strumpellin knockout cells, revealing that the WASH complex can assemble and localize to endocytic compartments in cells in the absence of strumpellin
Analysis of longitudinal variations in North Pacific alkalinity to improve predictive algorithms
The causes of natural variation in alkalinity in the North Pacific surface ocean need to be investigated to understand the carbon cycle and to improve predictive algorithms. We used GLODAPv2 to test hypotheses on the causes of three longitudinal phenomena in Alk*, a tracer of calcium carbonate cycling. These phenomena are (a) an increase from east to west between 45°N and 55°N, (b) an increase from west to east between 25°N and 40°N, and (c) a minor increase from west to east in the equatorial upwelling region. Between 45°N and 55°N, Alk* is higher on the western than on the eastern side, and this is associated with denser isopycnals with higher Alk* lying at shallower depths. Between 25°N and 40°N, upwelling along the North American continental shelf causes higher Alk* in the east. Along the equator, a strong east-west trend was not observed, even though the upwelling on the eastern side of the basin is more intense, because the water brought to the surface is not high in Alk*. We created two algorithms to predict alkalinity, one for the entire Pacific Ocean north of 30°S and one for the eastern margin. The Pacific Ocean algorithm is more accurate than the commonly used algorithm published by Lee et al. (2006), of similar accuracy to the best previously published algorithm by Sasse et al. (2013), and is less biased with longitude than other algorithms in the subpolar North Pacific. Our eastern margin algorithm is more accurate than previously published algorithms
Autogenous BrachialâBrachial Fistula for Vein Access. Haemodynamic Factors Predicting Outcome and 1 Year Clinical Data
AbstractTwo-stage autogenous brachial veinâbrachial artery access (ABBA) has been proposed as an option where adequate superficial vein is not available for the creation of conventional haemodialysis fistulae.MethodsThis report depicts the clinical outcome of a series of 17 consecutive patients who underwent ABBA in a single centre. Of the 17 patients, nine had had at least one previous arterioventricular (AV) fistula or graft, and eight were new to haemodialysis. Patencies were assessed using the KaplanâMeier survival analysis.ResultsIn 14 patients, the brachial vein was transposed (82%) and the time to transposition ranged from 4 to 26 weeks (median time: 6 weeks). The functional patency rate was 45.75% at 12 months. After stage one, all fistulas that went on to develop well had a brachial vein flow of at least 900mlminâ1, and this was significantly higher than in fistulas that failed to develop (p=0.005). The maturation rate in our study was 65% and the median time to cannulation of the fistula was 8weeks from the stage 1. Of the 17 patients, 12 (71%) experienced at least one complication. Ten (59%) demonstrated moderate-to-severe stenoses; eight of which necessitated angioplasty and/or percutaneous mechanical thrombolysis.ConclusionsABBA was characterised by a high incidence of complications and a long period to achieve maturation. Despite close monitoring and a high rate of secondary interventions, the patency rate was low. With this experience, we now only consider it an alternative in patients without adequate superficial veins, who have had failed grafts or where there is a very high risk of infection
Cybergriping: Violating the Law while E-Complaining
The emergence of Web communications has given rise to complaint sites which serve as central forums for both consumers and employees to share their bad experiences. These complaint sites provide for cybergriping in various forms. This paper explores the concept of cybergriping and its relevance to the hospitality and tourism industry from employee and customer perspectives. Court cases in which cybergriping played a key role are reviewed, and recommendations are offered on how hospitality and tourism businesses can address the problem of cybergriping
Parental diabetes and birthweight in 236 030 individuals in the UK biobank study
This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.BACKGROUND: The UK Biobank study provides a unique opportunity to study the causes and consequences of disease. We aimed to use the UK Biobank data to study the well-established, but poorly understood, association between low birthweight and type 2 diabetes. METHODS: We used logistic regression to calculate the odds ratio for participants' risk of type 2 diabetes given a one standard deviation increase in birthweight. To test for an association between parental diabetes and birthweight, we performed linear regression of self-reported parental diabetes status against birthweight. We performed path and mediation analyses to test the hypothesis that birthweight partly mediates the association between parental diabetes and participant type 2 diabetes status. RESULTS: Of the UK Biobank participants, 277 261 reported their birthweight. Of 257 715 individuals of White ethnicity and singleton pregnancies, 6576 had type 2 diabetes, 19 478 reported maternal diabetes (but not paternal), 20 057 reported paternal diabetes (but not maternal) and 2754 participants reported both parents as having diabetes. Lower birthweight was associated with type 2 diabetes in the UK Biobank participants. A one kilogram increase in birthweight was associated with a lower risk of type 2 diabetes (odds ratio: 0.74; 95% CI: 0.71, 0.76; P = 2 Ă 10(-57)). Paternal diabetes was associated with lower birthweight (45 g lower; 95% CI: 36, 54; P = 2 Ă 10(-23)) relative to individuals with no parental diabetes. Maternal diabetes was associated with higher birthweight (59 g increase; 95% CI: 50, 68; P = 3 Ă 10(-37)). Participants' lower birthweight was a mediator of the association between reported paternal diabetes and participants' type 2 diabetes status, explaining 1.1% of the association, and participants' higher birthweight was a mediator of the association between reported maternal diabetes and participants' type 2 diabetes status, explaining 1.2% of the association. CONCLUSIONS: Data from the UK Biobank provides the strongest evidence by far that paternal diabetes is associated with lower birthweight, whereas maternal diabetes is associated with increased birthweight. Our findings with paternal diabetes are consistent with a role for the same genetic factors influencing foetal growth and type 2 diabetes.ERDF (European Regional Development Fund)ESF (European Social Fund) Convergence Programme for Cornwall and the Isles of ScillyWellcome TrustThe European Research CouncilDiabetes U
Pearling: stroke segmentation with crusted pearl strings
We introduce a novel segmentation technique, called Pearling, for the semi-automatic extraction of idealized models of networks of strokes (variable width curves) in images. These networks may for example represent roads in an aerial photograph, vessels in a medical scan, or strokes in a drawing. The operator seeds the process by selecting representative areas of good (stroke interior) and bad colors. Then, the operator may either provide a rough trace through a particular path in the stroke graph or simply pick a starting point (seed) on a stroke and a direction of growth. Pearling computes in realtime the centerlines of the strokes, the bifurcations, and the thickness function along each stroke, hence producing a purified medial axis transform of a desired portion of the stroke graph. No prior segmentation or thresholding is required. Simple gestures may be used to trim or extend the selection or to add branches. The realtime performance and reliability of Pearling results from a novel disk-sampling approach, which traces the strokes by optimizing the positions and radii of a discrete series of disks (pearls) along the stroke. A continuous model is defined through subdivision. By design, the idealized pearl string model is slightly wider than necessary to ensure that it contains the stroke boundary. A narrower core model that fits inside the stroke is computed simultaneously. The difference between the pearl string and its core contains the boundary of the stroke and may be used to capture, compress, visualize, or analyze the raw image data along the stroke boundary
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