A Photometric Catalogue of Southern Emission-Line Stars

We present a catalogue of previously unpublished optical and infrared photometry for a sample of 162 emission-line objects and shell stars visible from the southern hemisphere. The data were obtained between 1978 and 1997 in the Walraven (WULBV), Johnson/Cousins (UBV(RI)_c) and ESO and SAAO near-infrared (JHKLM) photometric systems. Most of the observed objects are Herbig Ae/Be (HAeBe) stars or HAeBe candidates appearing in the list of HAeBe candidates of Th\'e et al. (1994), although several B[e] stars, LBVs and T Tauri are also included in our sample. For many of the stars the data presented here are the first photo-electric measurements in the literature. The resulting catalogue consists of 1809 photometric measurements. Optical variability was detected in 66 out of the 116 sources that were observed more than once. 15 out of the 50 stars observed multiple times in the infrared showed variability at 2.2 microns (K band).Comment: 42 pages, no figures, to appear in Astronomy & Astrophysic

Candidate X-ray-Emitting OB Stars in the Carina Nebula Identified Via Infrared Spectral Energy Distributions

We report the results of a new survey of massive, OB stars throughout the Carina Nebula using the X-ray point source catalog provided by the Chandra Carina Complex Project (CCCP) in conjunction with infrared (IR) photometry from the Two Micron All-Sky Survey and the Spitzer Space Telescope Vela--Carina survey. Mid-IR photometry is relatively unaffected by extinction, hence it provides strong constraints on the luminosities of OB stars, assuming that their association with the Carina Nebula, and hence their distance, is confirmed. We fit model stellar atmospheres to the optical (UBV) and IR spectral energy distributions (SEDs) of 182 OB stars with known spectral types and measure the bolometric luminosity and extinction for each star. We find that the extinction law measured toward the OB stars has two components: Av=1--1.5 mag produced by foreground dust with a ratio of total-to-selective absorption Rv=3.1 plus a contribution from local dust with Rv>4.0 in the Carina molecular clouds that increases as Av increases. Using X-ray emission as a strong indicator of association with Carina, we identify 94 candidate OB stars with Lbol\geq10^4 Lsun by fitting their IR SEDs. If the candidate OB stars are eventually confirmed by follow-up spectroscopic observations, the number of cataloged OB stars in the Carina Nebula will increase by ~50%. Correcting for incompleteness due to OB stars falling below the Lbol cutoff or the CCCP detection limit, these results potentially double the size of the young massive stellar population.Comment: 19 pages, 8 figures, accepted for the ApJS Special Issue on the Chandra Carina Complex Project (CCCP), scheduled for publication in May 2011. All 16 CCCP Special Issue papers, including a version of this article with high-quality figures, are available at http://cochise.astro.psu.edu/Carina_public/special_issue.html (through 2011 at least

EXPORT: optical photometry and polarimetry of Vega-type and pre-main sequence stars

This paper presents optical UBVRI broadband photo-polarimetry of the EXPORT sample obtained at the 2.5m Nordic Optical Telescope. The database consists of multi-epoch photo-polarimetry of 68 pre-main-sequence and main-sequence stars. An investigation of the polarization variability indicates that 22 objects are variable at the 3sigma level in our data. All these objects are pre-main sequence stars, consisting of both T Tauri and Herbig Ae/Be objects while the main sequence, Vega type and post-T Tauri type objects are not variable. The polarization properties of the variable sources are mostly indicative of the UXOR-type behaviour; the objects show highest polarization when the brightness is at minimum. We add seven new objects to the class of UXOR variables (BH Cep, VX Cas, DK Tau, HK Ori, LkHa 234, KK Oph and RY Ori). The main reason for their discovery is the fact that our data-set is the largest in its kind, indicating that many more young UXOR-type pre-main sequence stars remain to be discovered. The set of Vega-like systems has been investigated for the presence of intrinsic polarization. As they lack variability, this was done using indirect methods, and apart from the known case of BD +31.643, the following stars were found to be strong candidates to exhibit polarization due to the presence of circumstellar disks: 51 Oph, BD +31.643C, HD 58647 and HD 233517.Comment: A&A accepte

Cytoplasmic PML promotes TGF-β-associated epithelial–mesenchymal transition and invasion in prostate cancer

Epithelial–mesenchymal transition (EMT) is a key event that is involved in the invasion and dissemination of cancer cells. Although typically considered as having tumour-suppressive properties, transforming growth factor (TGF)-β signalling is altered during cancer and has been associated with the invasion of cancer cells and metastasis. In this study, we report a previously unknown role for the cytoplasmic promyelocytic leukaemia (cPML) tumour suppressor in TGF-β signalling-induced regulation of prostate cancer-associated EMT and invasion. We demonstrate that cPML promotes a mesenchymal phenotype and increases the invasiveness of prostate cancer cells. This event is associated with activation of TGF-β canonical signalling pathway through the induction of Sma and Mad related family 2 and 3 (SMAD2 and SMAD3) phosphorylation. Furthermore, the cytoplasmic localization of promyelocytic leukaemia (PML) is mediated by its nuclear export in a chromosomal maintenance 1 (CRM1)-dependent manner. This was clinically tested in prostate cancer tissue and shown that cytoplasmic PML and CRM1 co-expression correlates with reduced disease-specific survival. In summary, we provide evidence of dysfunctional TGF-β signalling occurring at an early stage in prostate cancer. We show that this disease pathway is mediated by cPML and CRM1 and results in a more aggressive cancer cell phenotype. We propose that the targeting of this pathway could be therapeutically exploited for clinical benefit

Immunohistochemical expression of promyelocytic leukemia body in soft tissue sarcomas

<p>Abstract</p> <p>Background</p> <p>The function of promyelocytic leukemia (PML) bodies is not well known but plays an important role in controlling cell proliferation, apoptosis and senescence. This study was undertaken to analyze the clinical significance of PML body expression in primary tumor samples from malignant fibrous histiocytoma (MFH) and liposarcoma patients.</p> <p>Methods</p> <p>We studied MFH and liposarcoma samples from 55 patients for PML bodies. Fluorescent immunostaining of PML bodies was performed in the paraffin-embedded tumor sections.</p> <p>Results</p> <p>PML body immunostaining was identified in 63.9% of MFH and 63.2% of liposarcoma samples. PML body expression rates of all sarcoma cells were 1.5 ± 1.8% (range: 0–7.0) in MFH and 1.3 ± 1.4% (0–5.2) in liposarcoma samples. PML body expression (p = 0.0053) and a high rate of PML body expression (p = 0.0012) were significantly greater prognostic risk factors for death than the other clinical factors in MFH patients. All liposarcoma patients without expression of PML were disease free at the end of the study.</p> <p>Conclusion</p> <p>Our study suggests that the presence of PML bodies may indicate a poor prognosis for MFH and liposarcoma patients.</p

WR20a: a massive cornerstone binary system comprising two extreme early-type stars

We analyse spectroscopic observations of WR20a revealing that this star is a massive early-type binary system with a most probable orbital period of \sim 3.675 days. Our spectra indicate that both components are most likely of WN6ha or O3If^*/WN6ha spectral type. The orbital solution for a period of 3.675 days yields extremely large minimum masses of 70.7 \pm 4.0 and 68.8 \pm 3.8 M_{\odot} for the two stars. These properties make WR20a a cornerstone system for the study of massive star evolution.Comment: 5 pages, 3 figures, accepted by A&A Letter

The evolution of rotating stars

First, we review the main physical effects to be considered in the building of evolutionary models of rotating stars on the Upper Main-Sequence (MS). The internal rotation law evolves as a result of contraction and expansion, meridional circulation, diffusion processes and mass loss. In turn, differential rotation and mixing exert a feedback on circulation and diffusion, so that a consistent treatment is necessary. We review recent results on the evolution of internal rotation and the surface rotational velocities for stars on the Upper MS, for red giants, supergiants and W-R stars. A fast rotation is enhancing the mass loss by stellar winds and reciprocally high mass loss is removing a lot of angular momentum. The problem of the ``break-up'' or $\Omega$-limit is critically examined in connection with the origin of Be and LBV stars. The effects of rotation on the tracks in the HR diagram, the lifetimes, the isochrones, the blue to red supergiant ratios, the formation of W-R stars, the chemical abundances in massive stars as well as in red giants and AGB stars, are reviewed in relation to recent observations for stars in the Galaxy and Magellanic Clouds. The effects of rotation on the final stages and on the chemical yields are examined, as well as the constraints placed by the periods of pulsars. On the whole, this review points out that stellar evolution is not only a function of mass M and metallicity Z, but of angular velocity $\Omega$ as well.Comment: 78 pages, 7 figures, review for Annual Review of Astronomy and Astrophysics, vol. 38 (2000