Imbibition in Double Phase Flow Through Porous Media

In this paper, the phenomenon of Imbibition in two immiscible phase flow through porous media is discussed. The Successive over Relaxation (S.O.R.) method is applied to solve the governing partial differential equation and the numerical results have been represented using graphs

Decay modes of 250No

The Fragment Mass Analyzer at the ATLAS facility has been used to unambiguously identify the mass number associated with different decay modes of the nobelium isotopes produced via 204Pb(48Ca,xn)(252-x)No reactions. Isotopically pure (>99.7%) 204Pb targets were used to reduce background from more favored reactions on heavier lead isotopes. Two spontaneous fission half-lives (t_1/2 = 3.7+1.1-0.8 us and 43+22-15 us) were deduced from a total of 158 fission events. Both decays originate from 250No rather than from neighboring isotopes as previously suggested. The longer activity most likely corresponds to a K-isomer in this nucleus. No conclusive evidence for an alpha branch was observed, resulting in upper limits of 2.1% for the shorter lifetime and 3.4% for the longer activity.Comment: RevTex4, 10 pages, 5 figures, submitted to PR

Effect of partial replacement of fishmeal with Eichhornia crassipes on growth and survival of Labeo rohita (Hamilton, 1822) juveniles

The objective of the study was to find out the effect of partial replacement of fish meal in the diet of Labeo rohita juveniles. In this experiment, the data pertaining to growth, survival rate, feed conversion ratio, protein efficiency ratio of L. rohita at partial replacement of fishmeal with E. crassipes were evaluated. For that purpose fry of approximately equal weight (57.97mg ± 1.25) were distributed in groups of 15 to each four aquaria at 0% (T1), 10% (T2), 20% (T3), 30% (T4) and 40% (T5) inclusion levels of aquatic macrophyte, Eichhornia crassipes. Maximum mean weight gain (235.25 ± 11.04 mg) was observed in T1 and minimum (165.06 ± 10.93 mg) was observed in T5 at the end of the experiment. Among the treatments tested, the highest survival (89.99% ± 1.93) was recorded in treatment T1 and minimum was found in T4 (79.99% ± 2.72). Lowest FCR was recorded in treatment T3 (2.02 ± 0.39) and highest was found in T5 (3.08 ± 0.59). Higher SGR was observed in treatment T1 (297.15 ± 18.78%) and minimum was observed in T5 (182.74 ± 18.45%). The study revealed a decrease in the growth performance indices as the percentage of water hyacinth increases. In present study also there was not much difference in growth rate upto 20% incorporation of E. crassipes in the diet. Also, significant difference was observed among treatments with respect to feed utilization (P<0.05)

Accidental detection of clinically silent compound heterozygous Hb D Punjab/Hb Q India while analyzing HbA1c by high performance liquid chromatography

HbA1c is routinely prescribed investigations for diagnosing and monitoring diabetes and high-performance liquid chromatography (HPLC) is preferred method which is also able to identify presence of hemoglobin variant. A case was encountered where presence of variant hemoglobin was indicated. On further investigation with three different instruments, diagnosis of compound heterozygous Hb D Punjab/Hb Q India was made. The chromatogram on Bio-Rad D10 showed Hb D Punjab (ααββHbD Punjab)-29.89% at 3.96 minutes retention time (RT), Hb Q India (ααHbQ Indiaββ) -9.5% with 4.45 minutes RT, hybrid of HbQ India/Hb D Punjab (ααHbQ IndiaββHbD Punjab)-6% with 4.66 minutes RT, Hb A2 (ααδδ) was 2.5% and Hb A (ααββ) was 52.2%. Analysis done on Bio-Rad variant V-II confirmed these findings. Analysis done on Sebia capillary electrophoresis revealed major peak of 50.9% in zone 9/Z(A) constituted by Hb A, second peak of 39.8% in zone 6/Z(D) constituted by co-elution of Hb D and Hb Q India, third peak of 8.8% in zone 3-4/Z(A2-C) constituted by co-elution of Hb A2 and hybrid of Hb D Punjab/Hb Q India and a fourth peak of 0.5% in zone 1 representing Hb A2HbQ India (ααHbQ Indiaδδ). Ideally variants detected while analyzing HbA1c should be further investigated for confirmation and result of which should be shared, discussed and the patient should be encouraged for screening of available family members for relevant variant hemoglobin. Combination of cation exchange HPLC and capillary electrophoresis in this case was sufficient to arrive at conclusion

Molecular Docking, Synthesis, Structure Illucidation, Admet Analysis and Biological Activity Evaluation of Some Fluorinated Chromene Derivatives

The paper constitutes the exploration performed to developed new fluorinated chromene derivations by coupling response of separate fluorinated amino composites using suitable coupling reagents. The response is clean which enable too easy workup and good yield. Chromene derivations (3a- h) are synthesized by coupling response between different fluoro aniline derivations and 6-( trifluoromethyl) -3,4-dihydro-2H-chromene-2-carboxylic acid, N, N ’- Dicyclohexylcarbodiimide( DCC) and( 2-( 1H- benzotriazol-1-yl) hexafluorophosphate( HBTU) are used as a coupling reagent. N, N ’- Dicyclohexylcarbodiimide urea is formed as a side product during response which can remove by filtration. The response was rapid-fire and was conducted at room temperature with high- to- excellentyields, chromene derivations were assessed for tyrosinase and α- glucosidase inhibitory conditioning. Depended on IC50 values. All novel chromenes displayed significant α- glucosidase inhibition compared with reference (IC50 = 7.80 mM). Likewise, the capability of the studied composites to inhibit tyrosinase was estimated and set up to be moderate ‘In silico studies were performed to explore the list modes of the chromenes at the list point of α- glucosidase and tyrosinase. Molecular docking results revealed the significance of hydrogen cling, hydrophobic, π- π mounding, πcation, and essence relations between the target enzymes and the synthesized composites. Inclusively, the results attained in the current work indicated that the studied chromenes may be regarded as supereminent composites for designing new chemicals potentially effective in conditions similar as skin diseases and diabetes mellitus

High prevalence of alpha thalassemia in the tribal community of the western part of India! Reality or myth? Can simple hematology parameters; MCV and MCH act as screening tools at birth?

Background: The majority of adult tribal subjects in the western part of India, show microcytic hypochromic red cells, and borderline anemia with a normal iron profile, suggesting a high prevalence of thalassemia in this population. Methods: The current study was designed to perform qualitative (to screen for Hb Bart’s) and quantitative (to estimate percentage of Hb Bart’s) hemoglobin electrophoresis with modification of the method, to evaluate the prevalence of α thalassemia and to determine gene frequency of α+ thal gene. Furthermore, the present study also aimed to evaluate common hematology parameters like MCV and MCH as screening tools to suspect α thalassemia at birth. Results: Based on hemoglobin electrophoresis, the prevalence of α thalassemia in all its forms was found to be 66.66%. The estimated gene frequency for α+ thal was found to be 0.7453 and based on that, the extrapolated prevalence of α thalassemia was 93.52% (55.55% homozygous and 37.97% heterozygous). MCV<100 fl and MCH<31 pg were found to be reliable screening tools to predict α thalassemia at birth in full-term uncomplicated pregnancy. Conclusions: Tribal community in the western part of India bears a very high prevalence of α thalassemia, it’s a reality and not a myth. Simple hematological parameters like MCV (<100 fl) and MCH (<31 pg) measured at birth can prove to be cost-effective surrogate markers for α thalassemia. Large scale study using confirmatory genetic analysis is required to validate the findings.

KINETIC AND THERMODYNAMIC STUDIES OF THE OXIDATION OF PERFUMERY ALCOHOLS USING POTASSIUM PERIODATE IN ACIDIC MEDIUM

ABSTRACT Oxidation is one of the most important industrial reactions as it yields useful products. Literature survey indicates the use of a variety of organic oxidants for the oxidation of alcohols to the corresponding carbonyl compounds but inorganic oxidants have rarely been used. The quantitative conversion of alcohols to aldehydes/ketones has been reported by several workers but there are relatively few reports about the kinetic and thermodynamic investigations of the oxidation of alcohols. We report herein the kinetics of the controlled oxidation of some perfumery and fragrance alcohols using potassium periodate (KIO 4 ) in acidic medium. The secondary cyclic alcohols, borneol, isoborneol and menthol are extensively used in the manufacture of perfumes and fragrances. Menthol is also used in medicine as a local anaesthetic and counter irritant. The aliphatic alcohols, 2-propanol, 2-butanol and 3-methyl-1-butanol are used as diluents in perfumery formulations. The oxidation was carried out under pseudo uni-molecular kinetic conditions with respect to the inorganic oxidant. The progress of the reaction was monitored by iodometric estimation of the oxidant at regular time intervals during the course of the reaction. For all the alcohols studied, it was found that the oxidation rate increased with alcohol concentration but decreased with oxidant concentration

A review on a deep learning perspective in brain cancer classification

AWorld Health Organization (WHO) Feb 2018 report has recently shown that mortality rate due to brain or central nervous system (CNS) cancer is the highest in the Asian continent. It is of critical importance that cancer be detected earlier so that many of these lives can be saved. Cancer grading is an important aspect for targeted therapy. As cancer diagnosis is highly invasive, time consuming and expensive, there is an immediate requirement to develop a non-invasive, cost-effective and efficient tools for brain cancer characterization and grade estimation. Brain scans using magnetic resonance imaging (MRI), computed tomography (CT), as well as other imaging modalities, are fast and safer methods for tumor detection. In this paper, we tried to summarize the pathophysiology of brain cancer, imaging modalities of brain cancer and automatic computer assisted methods for brain cancer characterization in a machine and deep learning paradigm. Another objective of this paper is to find the current issues in existing engineering methods and also project a future paradigm. Further, we have highlighted the relationship between brain cancer and other brain disorders like stroke, Alzheimer’s, Parkinson’s, andWilson’s disease, leukoriaosis, and other neurological disorders in the context of machine learning and the deep learning paradigm