Interfacial bond behaviour of GFRP bar in self-compacting fiber reinforced concrete

In an ongoing research project, discrete steel fibers are being used in a self-compacting concrete (SFRSCC) to replace completely steel stirrups for pre-fabricated beams reinforced longitudinally with pre-stressed glass fiber reinforced polymer (GFRP) and steel bars. To take the advantages of the non-corrodible character and high tensile strength of GFRP bars, the minimum SFRSCC cover needs to be determined in order to assure the adequate bond performance between these bars and the surrounding SFRSCC. Since bond of the longitudinal bars has a relevant impact on the cracking behavior of RC elements (crack opening and crack spacing), an extensive experimental program composed of pullout bending tests was carried out where the influence of the following parameters was assessed in terms of bond behavior: GFRP bar diameter, surface characteristics of the GFRP bars, bond length, SFRSCC cover thickness. The local bond law was derived from inverse analysis and it was used to define the slip mode of the constitutive law adopted for interface finite elements. These interface finite elements were used to assess the crack opening and crack spacing on SFRSCC beams flexurally reinforced with GFRP bars. This paper resumes the experimental program, describes the strategy to derive the local bond law and presents and discusses the numerical simulations

Shear capacity of HPFRC beams flexurally reinforced with steel and prestressed GFRP bars

This paper presents the relevant results from an experimental program to assess the shear capacity of high performance fiber reinforced concrete (HPFRC) beams flexurally reinforced with a hybrid system of passive steel and prestressed GFRP longitudinal bars. Three series of two beams with different level of prestressing were tested. The effect of prestressing level on the shear capacity of the beams was the main investigated parameter. The results showed an enhancement of the load carrying capacity, ductility and energy absorption with the increase of the prestress level. Based on the obtained results, the predictive performance of the analytical formulations of CEB-FIP Model Code 2010 and RILEM TC 162-TDF for the shear capacity of FRC beams was assessed. Both formulations seem appropriate for design purposes, but the CEB-FIP formulation predicts more conservative shear capacity. The experimental results demonstrated that the prestressing level has an effect on the shear capacity much higher than the one recommended by the codes

Analytical bond model for GFRP bars to steel fiber reinforced self-compacting concrete

The objective of this study is to present a computational algorithm to analytically evaluate the bond behavior between GFRP bar and steel fiber reinforced self-compacting concrete (SFRSCC). The type of information to be derived is appropriate to study the flexural behavior of SFRSCC beams reinforced with GFRP bars in terms of serviceability limit states requirements; in fact the bond between bars and surrounding concrete influences significantly the crack width and crack spacing. The proposed bond model was established by calibrating the parameters of a multilinear bond-slip constitutive law using the experimental results of pullout bending tests carried out by the authors, taking into account the experimental pullout force versus slip at loaded and free ends. According to the comparison between theoretical and experimental pullout force-slip, an acceptable accuracy of the model was observed. Additionally, by considering the proposed bond-slip relationship, a parametric study was carried out to evaluate the influence of the involved bond-slip law’s parameters on the maximum force transferred to the surrounding concrete. Finally, the development length of two GFRP bars utilized in the experiments (deformed and smooth bars) was determined by means of the proposed model, and it was compared with the values recommended by codes.Fundação para a Ciência e a Tecnologia (FCT

The Role of mathematical thought in the improvement of architecture students’ abilities on logical aspects of design

Background and Objectives: Architectural education as a challengeable subject is dependent on multiple variables. Since formation of an architect character and learning design abilities are related to this subject, it is so sensitive.  Historically, the role of mathematics and application of its different aspects in architectural design is indisputable. While recent decades have witnessed a high level of interaction between mathematics and architecture in the world, mathematics in architectural education in Iran is still being taught as a basic course through the lecture method. A great concern in learning architectural design is how to apply the basic courses in design process. Methods: According to the necessity of revising the role of mathematics in education of architectural design, and developing new approaches to apply mathematical thought in logical process of design, the present study aims to test an educational model in an environment consisting of test and control groups in the Basic Design 1 & 2 courses, using the proposed model of Lawson as well as quasi-experimental research method. The research subjects are selected among BA students of Islamic Azad University of Urmia (n=52). They provided logical solutions for design problems, using algebraic, arithmetic, geometric and symbolic aspects of mathematics. The subjects’ design abilities were evaluated by the performance measurement method based on verdict criteria. The researchers determined two groups of mathematical and architectural design measurement criteria. For design, the criteria included design conceptual quality, spatial and functional arrangement, form combination, presentation quality, creativity and final grade.  Findings: The final grades of four research projects executed in two studios were respectively for design 62.57,66.29, 71.30, 75.31 and for mathematics 64.99, 69.27, 71.72 and 74.9. The correlation between design and mathematics evaluation scores for project 1 of the studio 1 (ƿ=0.594) and project 2 of the studio 2 (ƿ=0.604) is independently obvious which indicates the strong combination between mathematics and design aspects in these projects. For the project 2 of the studio 1, the correlation was low (ƿ= 0.166). The possible explanation could be based on the lack of real materials application and the experiment of altering theory analysis to practical analysis. The correlation between design evaluation scores and mathematics application (ƿ=0.384) reveals a positive role for mathematical thought in developing logical solutions and general quality of design. Conclusion: Findings of this study directly refers to the correspondence between research assumptions and the verdict criteria. The findings indicate that students’ performance in test group is better than the students in control group in all criteria except the presentation. The best performance by subjects of the test group means that their ability in creating solution concept has much improved compared with the control group as a result of manipulating the independent variable which is the education method in this study. This improvement couldn’t be related to other unrelated independent variables, because these variables have been either controlled or their effect has been studied through the pre-test. Stated on the findings in analyzing the general quality of design, students provided complicated geometric patterns in their design as logical, creative and efficient solutions through realizing their mathematical principles. Acquiring and developing the design schema based on design problems in the Basic design studios results the improvement of the students’ ability in logical aspects of design.   ===================================================================================== COPYRIGHTS  ©2020 The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is required from the authors or the publishers.  ====================================================================================

Investigation of grapevine areas under climatic stress using high resolution atmospheric modelling: case studies in South Africa and New Zealand

High-resolution atmospheric simulations (500 m) were used to assess viticultural areas under climatic stress in South Africa and New Zealand. The potential areas in which high daytime temperature stress was likely to affect grapevine photosynthesis and grape composition were identified. Results indicated different diurnal temperature variations within the two areas due to synoptic and local environmental factors, often associated with the influence of terrain

The generalized second law for the interacting generalized Chaplygin gas model

We investigate the validity of the generalized second law (GSL) of gravitational thermodynamics in a non-flat FRW universe containing the interacting generalized Chaplygin gas with the baryonic matter. The dynamical apparent horizon is assumed to be the boundary of the universe. We show that for the interacting generalized Chaplygin gas as a unified candidate for dark matter (DM) and dark energy (DE), the equation of state parameter can cross the phantom divide. We also present that for the selected model under thermal equilibrium with the Hawking radiation, the GSL is always satisfied throughout the history of the universe for any spatial curvature, independently of the equation of state of the interacting generalized Chaplygin gas model.Comment: 8 page

Interacting entropy-corrected new agegraphic dark energy in Brans-Dicke cosmology

Motivated by a recent work of one of us [1], we extend it by using quantum (or entropy) corrected new agegraphic dark energy in the Brans-Dicke cosmology. The correction terms are motivated from the loop quantum gravity which is one of the competitive theories of quantum gravity. Taking the non-flat background spacetime along with the conformal age of the universe as the length scale, we derive the dynamical equation of state of dark energy and the deceleration parameter. An important consequence of this study is the phantom divide scenario with entropy-corrected new agegraphic dark energy. Moreover, we assume a system of dark matter, radiation and dark energy, while the later interacts only with dark matter. We obtain some essential expressions related with dark energy dynamics. The cosmic coincidence problem is also resolved in our model.Comment: 16 pages, no figure, accepted for publication in Gen. Relativ. Gra

Zilucoplan in immune-mediated necrotising myopathy: a phase 2, randomised, double-blind, placebo-controlled, multicentre trial

BACKGROUND: Immune-mediated necrotising myopathy is an autoimmune myopathy characterised by proximal muscle weakness, high creatine kinase concentrations, and autoantibodies recognising 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) or the signal recognition particle (SRP). No approved therapies exist for people with immune-mediated necrotising myopathy. Previous studies have suggested that complement activation might be pathogenic in immune-mediated necrotising myopathy; therefore, zilucoplan, a complement C5 (C5) inhibitor, could be a potential therapy. We aimed to evaluate the efficacy, safety, and tolerability of zilucoplan in adult participants with anti-HMGCR or anti-SRP autoantibody-positive immune-mediated necrotising myopathy. METHODS: IMNM-01 was a phase 2, multicentre, randomised, double-blind, placebo-controlled study done at 15 hospital sites across the USA, the UK, France, and the Netherlands. Participants aged 18–74 years were eligible for inclusion if they had a clinically confirmed diagnosis of immune-mediated necrotising myopathy, positive serology for anti-HMGCR or anti-SRP autoantibodies, clinical evidence of weakness, serum total creatine kinase concentration of more than 1000 U/L at screening, and no change in glucocorticoids or other immunosuppressive therapies for 30 days before baseline or expected during the first 8 weeks of the study. Participants were randomly assigned (1:1) to receive daily subcutaneous zilucoplan (0·3 mg/kg) or placebo for 8 weeks by use of a computerised randomisation algorithm; with optional enrolment in the study open-label extension. Randomisation was stratified by autoantibody status. Participants and study staff were masked to treatment group assignment. Primary efficacy endpoint (in the intent-to-treat population, defined as all participants who were randomly assigned to a treatment group) was percent change from baseline to week 8 in creatine kinase concentrations. Safety analyses were performed on the safety population (participants who received at least one dose of study drug during the main study, irrespective of whether they continued to the extension period—study participants were analysed on the basis of the treatment received). This study is registered with ClinicalTrials.gov, NCT04025632. FINDINGS: Between Nov 7, 2019, and Jan 7, 2021, we randomly assigned 27 participants (13 female and 14 male) to receive zilucoplan (n=12) or placebo (n=15). All 27 participants completed the 8-week main study. At week 8 there were no significant differences between treatment groups in median percent change of creatine kinase concentrations versus baseline (–15·1% [IQR –31·1 to 3·2] in the zilucoplan group vs –16·3% [–43·8 to 5·9] in the placebo group; p=0·46) and no clinically relevant improvement over time within the treatment group despite target engagement based on mode of action. There were no unexpected adverse safety or tolerability findings. Treatment-emergent adverse events were reported in nine (75%) of 12 participants in the zilucoplan group, and in 13 (87%) of 15 participants in the placebo group, and serious treatment-emergent adverse events were reported in zero participants in the zilucoplan group and three (20%) participants in the placebo group. The most frequent treatment-emergent adverse events were headache (four [33%] participants in the zilucoplan group and four [27%] participants in the placebo group) and nausea (three [25%] participants in the zilucoplan group and three [20%] participants in the placebo group). INTERPRETATION: C5 inhibition does not appear to be an efficacious treatment modality for people with immune-mediated necrotising myopathy. Rather than being the primary driver for disease activity, complement activation might be secondary to muscle injury. FUNDING: Ra Pharmaceuticals (now part of UCB Pharma)

Gabapentin for the hemodynamic response to intubation: systematic review and meta-analysis

Purpose Endotracheal intubation is the gold standard for securing the airway before surgery. Nevertheless, this procedure can produce an activation of the sympathetic nervous system and result in a hemodynamic response which, in high-risk patients, may lead to cardiovascular instability and myocardial ischemia. The aim of this review was to evaluate whether gabapentin can attenuate this response and whether such an attenuation could translate into reduced myocardial ischemia and mortality. Source We searched MEDLINE®, EMBASE™, CINAHL, AMED, and unpublished clinical trial databases for randomized-controlled trials that compared gabapentin with control, fentanyl, clonidine, or beta blockers for attenuating the hemodynamic response to intubation. Primary outcomes were mortality, myocardial infarction, and myocardial ischemia. Secondary outcomes were hemodynamic changes following intubation. Principal findings We included 29 randomized trials with only two studies at low risk of bias. No data were provided for the primary outcomes and no studies included high-risk patients. The use of gabapentin resulted in attenuation in the rise in mean arterial blood pressure [mean difference (MD), −12 mmHg; 95% confidence interval (CI), −17 to −8] and heart rate (MD, −8 beats·min−1; 95% CI, −11 to −5) one minute after intubation. Gabapentin also reduced the risk of hypertension or tachycardia requiring treatment (risk ratio, 0.15; 95% CI, 0.05 to 0.48). Data were limited on adverse hemodynamic events such as bradycardia and hypotension. Conclusion It remains unknown whether gabapentin improves clinically relevant outcomes such as death and myocardial infarction since studies failed to report on these. Nevertheless, gabapentin attenuated increases in heart rate and blood pressure following intubation when compared with the control group. Even so, the studies included in this review were at potential risk of bias. Moreover, they did not include high-risk patients or report adverse hemodynamic outcomes. Future studies are required to address these limitations