A new HW Vir binary from the Palomar Transient Factory: PTF1 J072455.75+125300.3 - An eclipsing subdwarf B binary with a M-star companion

We report the discovery of an eclipsing binary -- PTF1 J072456$+$125301-- composed of a subdwarf B (sdB) star ($g'=17.2^m$) with a faint companion. Subdwarf B stars are core helium-burning stars, which can be found on the extreme horizontal branch. About half of them reside in close binary systems, but few are known to be eclipsing, for which fundamental stellar parameters can be derived.\newline We conducted an analysis of photometric data and spectra from the Palomar 60'' and the 200" Hale telescope respectively. A quantitative spectral analysis found an effective temperature of $T_{\text{eff}}=33900\pm350$\,K, log g = $5.74\pm0.08$ and log($n_{\text{He}}/n_{\text{H}}) = -2.02 \pm0.07$, typical for an sdB star. The companion does not contribute to the optical light of the system, except through a distinct reflection effect. From the light curve an orbital period of 0.09980(25)\,d and a system inclination of 83.56\pm0.30\,^{\circ} were derived. The radial velocity curve yielded an orbital semi-amplitude of K_1=95.8\pm 8.1\,\text{km s^{-1}}. The mass for the M-type dwarf companion is $0.155\pm0.020\,M_{\odot}$. PTF1\,J072456$+$125301 has similar atmospheric parameters to those of pulsating sdB stars (V346 Hya stars). Therefore it could be a high-priority object for asteroseismology, if pulsations were detected such as in the enigmatic case of NY Vir.Comment: Accepted to A&A, 7pages, 4 figure

Mass extinctions and supernova explosions

A nearby supernova (SN) explosion could have negatively influenced life on Earth, maybe even been responsible for mass extinctions. Mass extinction poses a significant extinction of numerous species on Earth, as recorded in the paleontologic, paleoclimatic, and geological record of our planet. Depending on the distance between the Sun and the SN, different types of threats have to be considered, such as ozone depletion on Earth, causing increased exposure to the Sun's ultraviolet radiation, or the direct exposure of lethal x-rays. Another indirect effect is cloud formation, induced by cosmic rays in the atmosphere which result in a drop in the Earth's temperature, causing major glaciations of the Earth. The discovery of highly intensive gamma ray bursts (GRBs), which could be connected to SNe, initiated further discussions on possible life-threatening events in Earth's history. The probability that GRBs hit the Earth is very low. Nevertheless, a past interaction of Earth with GRBs and/or SNe cannot be excluded and might even have been responsible for past extinction events.Comment: Chapter for forthcoming book: Handbook of Supernovae, P. Murdin and A. Alsabeti (eds.), Springer International Publishing (in press

Extraction of specific parameters for skin tumour classification

In this paper, a methodological approach to the classification of tumour skin lesions in dermoscopy images is presented. Melanomas are the most malignant skin tumours. They grow in melanocytes, the cells responsible for pigmentation. This type of cancer is increasing rapidly; its related mortality rate is increasing more modestly, and inversely proportional to the thickness of the tumour. The mortality rate can be decreased by earlier detection of suspicious lesions and better prevention. Using skin tumour features such as colour, symmetry and border regularity, an attempt is made to determine if the skin tumour is a melanoma or a benign tumour. In this work, we are interested in extracting specific attributes which can be used for computer-aided diagnosis of melanoma, especially among general practitioners. In the first step, we eliminate surrounding hair in order to eliminate the residual noise. In the second step, an automatic segmentation is applied to the image of the skin tumour. This method reduces a colour image into an intensity image and approximately segments the image by intensity thresholding. Then, it refines the segmentation using the image edges, which are used to localize the boundary in that area of the skin. This step is essential to characterize the shape of the lesion and also to locate the tumour for analysis. Then, a sequences of transformations is applied to the image to measure a set of attributes (A: asymmetry, B: border, C: colour and D: diameter) which contain sufficient information to differentiate a melanoma from benign lesions. Finally, the various signs of specific lesion (ABCD) are provided to an artificial neural network to differentiate between malignant tumours and benign lesions

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

Most human pre-mRNAs are spliced into linear molecules that retain the exon order defined by the genomic sequence. By deep sequencing of RNA from a variety of normal and malignant human cells, we found RNA transcripts from many human genes in which the exons were arranged in a non-canonical order. Statistical estimates and biochemical assays provided strong evidence that a substantial fraction of the spliced transcripts from hundreds of genes are circular RNAs. Our results suggest that a non-canonical mode of RNA splicing, resulting in a circular RNA isoform, is a general feature of the gene expression program in human cells

The Origin and Initial Rise of Pelagic Cephalopods in the Ordovician

BACKGROUND: During the Ordovician the global diversity increased dramatically at family, genus and species levels. Partially the diversification is explained by an increased nutrient, and phytoplankton availability in the open water. Cephalopods are among the top predators of today's open oceans. Their Ordovician occurrences, diversity evolution and abundance pattern potentially provides information on the evolution of the pelagic food chain. METHODOLOGY/PRINCIPAL FINDINGS: We reconstructed the cephalopod departure from originally exclusively neritic habitats into the pelagic zone by the compilation of occurrence data in offshore paleoenvironments from the Paleobiology Database, and from own data, by evidence of the functional morphology, and the taphonomy of selected cephalopod faunas. The occurrence data show, that cephalopod associations in offshore depositional settings and black shales are characterized by a specific composition, often dominated by orthocerids and lituitids. The siphuncle and conch form of these cephalopods indicate a dominant lifestyle as pelagic, vertical migrants. The frequency distribution of conch sizes and the pattern of epibionts indicate an autochthonous origin of the majority of orthocerid and lituitid shells. The consistent concentration of these cephalopods in deep subtidal sediments, starting from the middle Tremadocian indicates the occupation of the pelagic zone early in the Early Ordovician and a subsequent diversification which peaked during the Darriwilian. CONCLUSIONS/SIGNIFICANCE: The exploitation of the pelagic realm started synchronously in several independent invertebrate clades during the latest Cambrian to Middle Ordovician. The initial rise and diversification of pelagic cephalopods during the Early and Middle Ordovician indicates the establishment of a pelagic food chain sustainable enough for the development of a diverse fauna of large predators. The earliest pelagic cephalopods were slowly swimming vertical migrants. The appearance and early diversification of pelagic cephalopods is interpreted as a consequence of the increased food availability in the open water since the latest Cambrian

Lessons from non-canonical splicing

Recent improvements in experimental and computational techniques that are used to study the transcriptome have enabled an unprecedented view of RNA processing, revealing many previously unknown non-canonical splicing events. This includes cryptic events located far from the currently annotated exons and unconventional splicing mechanisms that have important roles in regulating gene expression. These non-canonical splicing events are a major source of newly emerging transcripts during evolution, especially when they involve sequences derived from transposable elements. They are therefore under precise regulation and quality control, which minimizes their potential to disrupt gene expression. We explain how non-canonical splicing can lead to aberrant transcripts that cause many diseases, and also how it can be exploited for new therapeutic strategies