188 research outputs found
Calibrations of hydro-acoustic instruments onboard FORV Sagar Sampada
Calibration is carried out to keep up the precision of the instruments by
determining their calibre. CaUbration of hydro acoustic equipments onboard FORV
Sagar Sampada was carried out periodically and the performance records were
maintained. Deviation and the deficiencies were noted down for applying the correction
while interpreting the output of the instruments
Proceedings of the Second workshop on scientific results of FORV Sagar Sampada
Since inception in 1984, the Fisheries and Oceanographic Research Vessel
Sagar Sampada, with sophisticated modern facilities onboard, has undertaken more
than 140 cruises all over the Indian Ocean primarily in our Exclusive Economic Zone
for fishery and oceanographic survey. Scientists from many institutions have made
use of this facility to explore the resource potential in our sea and to understand its
correlation with the environmental parameters. These survey and exploration efforts
are continuing.
This volume contains many papers which are the outcome of research work carried
out onboard 'Sagar Sampada' during last five years (1989-1993) and presented in a
Workshop to evaluate the scientific work. About 60 papers, included in this volume,
bring out the results pertaining to environmental assessment, hydrology, productivity
estimates, fishery resources availability, fishing technology, pollution monitoring etc.
These relate mainly to the Arabian Sea, Bay of Bengal and Lakshadweep, Andaman
and Nicobar Islands groups in the EEZ of India. These efforts along with other
mission-oriented cruises have yielded valuable information on the fishery resources
and their distribution in space and time
Why are MD simulated protein folding times wrong?
The question of significant deviations of protein folding times simulated using molecular dynamics from experimental values is investigated. It is shown that in the framework of Markov State Model (MSM) describing the conformational dynamics of peptides and proteins, the folding time is very sensitive to the simulation model parameters, such as forcefield and temperature. Using two peptides as examples, we show that the deviations in the folding times can reach an order of magnitude for modest variations of the molecular model. We, therefore, conclude that the folding rate values obtained in molecular dynamics simulations have to be treated with care
Influence of calcination temperature on structural and magnetic properties of nanocomposites formed by Co-ferrite dispersed in sol-gel silica matrix using tetrakis(2-hydroxyethyl) orthosilicate as precursor
Effects of calcination temperatures varying from 400 to 1000°C on structural and magnetic properties of nanocomposites formed by Co-ferrite dispersed in the sol-gel silica matrix using tetrakis(2-hydroxyethyl) orthosilicate (THEOS) as water-soluble silica precursor have been investigated. Studies carried out using XRD, FT-IR, TEM, STA (TG-DTG-DTA) and VSM techniques. Results indicated that magnetic properties of samples such as superparamagnetism and ferromagnetism showed great dependence on the variation of the crystallinity and particle size caused by the calcination temperature. The crystallization, saturation magnetization Ms and remenant magnetization Mr increased as the calcination temperature increased. But the variation of coercivity Hc was not in accordance with that of Ms and Mr, indicating that Hc is not determined only by the crystallinity and size of CoFe2O4 nanoparticles. TEM images showed spherical nanoparticles dispersed in the silica network with sizes of 10-30 nm. Results showed that the well-established silica network provided nucleation locations for CoFe2O4 nanoparticles to confinement the coarsening and aggregation of nanoparticles. THEOS as silica matrix network provides an ideal nucleation environment to disperse CoFe2O4 nanoparticles and thus to confine them to aggregate and coarsen. By using THEOS as water-soluble silica precursor over the currently used TEOS and TMOS, the organic solvents are not needed owing to the complete solubility of THEOS in water. Synthesized nanocomposites with adjustable particle sizes and controllable magnetic properties make the applicability of Co-ferrite even more versatile
A patient-derived explant (PDE) model of hormone-dependent cancer
Breast and prostate cancer research to date has largely been predicated on the use of cell lines in vitro or in vivo. These limitations have led to the development of more clinically relevant models, such as organoids or murine xenografts that utilize patient-derived material; however, issues related to low take rate, long duration of establishment, and the associated costs constrain use of these models. This study demonstrates that ex vivo culture of freshly resected breast and prostate tumor specimens obtained from surgery, termed patient-derived explants (PDEs), provides a high-throughput and cost-effective model that retains the native tissue architecture, microenvironment, cell viability, and key oncogenic drivers. The PDE model provides a unique approach for direct evaluation of drug responses on an individual patient's tumor, which is amenable to analysis using contemporary genomic technologies. The ability to rapidly evaluate drug efficacy in patient-derived material has high potential to facilitate implementation of personalized medicine approaches.Margaret M. Centenera, Theresa E. Hickey, Shalini Jindal, Natalie K. Ryan, Preethi Ravindranathan, Hisham Mohammed, Jessica L. Robinson, Matthew J. Schiewer, Shihong Ma, Payal Kapur, Peter D. Sutherland, Clive E. Hoffmann, Claus G. Roehrborn, Leonard G. Gomella, Jason S. Carroll, Stephen N. Birrell, Karen E. Knudsen, Ganesh V. Raj, Lisa M. Butler, Wayne D. Tille
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