Direct Displacement Based Design of Regular Steel Moment Resisting Frames

AbstractDisplacement Based Design method represents a new approach to performance-based design. This research tries to assess the Direct Displacement Based Design (DDBD) method for regular steel moment resisting frames and develop a reliable design method for them so that they withstand various seismic levels within certain performance levels. For this purpose, regular steel frames with 4, 8, 12, 16 stories are designed based on DDBD approach utilizing displacement spectrum of the Iranian Code of Practice for Seismic Resistant Design of Buildings (Standard No. 2800). In order to evaluate seismic response of the designed structures, a series of non-linear time-history analyses have been performed under different records compatible with Standard No. 2800. All the non-linear analyses were carried out using the fiber-element models developed in Seismostruct computer program. According to the results, inter-story drift profile of the structure which is corresponding to its damage was less than the allowable value in most cases. Also, Maximum displacement profile of the structure along its height is completely matched with the primary assumed design profile. The structures have mostly experienced similar residual drift values under different records. In summary, the method performed quite satisfactorily in terms of story maximum displacements, maximum interstory drifts and story ductility demands, even for tall models

Glutathione, cell proliferation and differentiation

All organisms require an equivalent source for living. Reduced glutathione is the most abundant thiol containing protein in mammalian cells and organs. Glutathione was discovered by Hopkins in 1924 who published his findings in JBC. It is a three peptide containing glutamic acid, cystein and glycin and is found in reduced and oxide forms in cell. High concentration of glutathione and its high reduced/oxide potential makes GSH a powerful antioxidant and the first defense line against free radicals. However, glutathione is the most efficient tool for detoxification of xenobiotic. In several studies, the effect of GSH on different cell types has been investigated and so, in this study, a review of the glutathione function, focusing on cell proliferation and differentiation would be carried out.Key words: Glutathione, proliferation, differentiatio

Effect of replacing fish meal with canola meal on growth performance, survival and body composition of Siberian sturgeon (Acipenser baerii Brandt)

This study was conducted to evaluate the effect of replacing dietary fish rations with canola rations on the growth rate, survival rate and body composition of the Siberian sturgeon (Acipenser baerii Brandt). Five isonitrogenous (45% crude protein) and isocaloric (18.53 MJg^-1) diets were formulated by replacing 0 (control), 10 (C_10), 20 (C_20), 30 (C_30) and 40% (C_40) of fish rations with canola rations. Juvenile fish with an initial weight of 22.80 ± 0.34 g (mean ± SD) with five treatments and three replications were fed for 10 weeks. At the end of the experiment, the growth rate, survival rate and body composition of the fish were measured. The results of this study showed that there was significant differences in the growth indices and body composition of the fish that were fed the different diets (P0.05). The survival rate was 100% in all treatments. There were no significant differences in body protein, lipid and ash contents in the different treatments (P>0.05), but significant differences were observed in the moisture content of the body of the fish that were fed different diets (P<0.05). The results of the present study suggest that 30% of fish rations can be replaced by canola rations without any negative effects on the growth rate, survival rate and body composition of the Siberian sturgeon

Seroprevalence of cytomegalovirus among women of reproductive age in iran: A systematic review and meta-analysis

Background: Human cytomegalovirus (CMV) able to cause infection for an entire lifetime. This systematic review and meta-analysis was conducted to determine seroprevalence of CMV among women of reproductive age in Iran. Methods: English and Persian databases such as Web of Science (WOS), PubMed, Scopus, Cochrane Library, SID, Iran doc, Iran Medex, Magiran, and Medlib were searched (from 2008 to 2017) accurately using the keywords: Cytomegalovirus, Pregnant women or Pregnancy, Epidemiology, Prevalence and Iran. Results: Results of 15 studies with total samples of 5253 persons from 2008 to 2017 were combined and meta-analyzed. The pooled prevalence rate of IgG among women was estimated 90 (95 CI: 87-93). The highest prevalence rate of IgG was in Tehran, Rasht, Mashhad and Yasoj, all 100 (95 CI: 100-100), and the lowest prevalence was in Jahrom 0.62 (95 CI: 53-71). The overall prevalence rate of IgM among women was estimated at 0.06 (95 CI: 0.03-0.13). The highest prevalence rate of IgM was in Kerman 0.34 (95 CI: 0.29-0.39) and Mashhad 0.25 (95 CI: 0.2-0.31), and the lowest prevalence was in Yasoj 0 (95 CI: 0.00-0.00) Conclusion: The prevalence of immunity in Iran, is satisfactory. Nevertheless, to maintain and increase the level of immunity across the country, it is necessary to routinely screen the women of reproductive ages across the country. © 2019, Iranian Journal of Public Health. All rights reserved

Risk factor investigation for cardiovascular health through WHO STEPS approach in Ardabil, Iran

Objectives: Reliable evidence is the keystone for any noncommunicable disease (NCD) prevention plan to be initiated. In this study we carried out a risk factor investigation based on the WHO Stepwise approach to Surveillance (STEPS). Methods: The study was conducted on 1000 adults between 15 and 64 years of age living in Ardabil province, north-west Iran during 2006, based on the WHO STEPS approach to surveillance of risk factors for NCD. At this stage only the first and second steps were carried out. Data were collected through standard questionnaires and methods analyzed using STATA version 8 statistical software package. Results: 29.0% of men and 2.6% of women were current daily tobacco smokers. The mean number of manufactured cigarettes smoked per day was 18.9 among current daily smokers. Smoking was most prevalent among men of low-income families and those of lower education The mean body mass index (BMI) was 26.6 kg/m2, and was significantly correlated with systolic blood pressure. 58.9% were overweight or obese; 18.0% had raised blood pressure and 3.7% had isolated systolic hypertension. The mean number of servings of fruit consumed per day was 1.1; 33.1% had low levels of activity. Combined risk factor analysis showed that 4.1%of participants were in the low-risk group (up to 5.1% among men and 3.2% among women).Those in the high-risk group comprised 25.6% in the 25- to 44-year age group and 49.7%in the 45- to 64-year age group. Mean BMI increased by age in both sexes at least at the firstthree decades of adult life. Conclusion: Based on observed status of risk for cardiovascular health, burden of cardiovascular diseases is expected to increase if an effective prevention strategy is not undertaken

Sensorineural deafness and male infertility: A contiguous gene deletion syndrome

Background: Syndromic hearing loss that results from contiguous gene deletions is uncommon. Deafness-infertility syndrome (DIS) is caused by large contiguous gene deletions at 15q15.3. Methods: Three families with a novel syndrome characterised by deafness and infertility are described. These three families do not share a common ancestor and do not share identical deletions. Linkage was established by completing a genome-wide scan and candidate genes in the linked region were screened by direct sequencing. Results: The deleted region is about 100 kb long and involves four genes (KIAA0377, CKMT1B, STRC and CATSPER2), each of which has a telomeric duplicate. This genomic architecture underlies the mechanism by which these deletions occur. CATSPER2 and STRC are expressed in the sperm and inner ear, respectively, consistent with the phenotype in persons homozygous for this deletion. A deletion of this region has been reported in one other family segregating male infertility and sensorineural deafness, although congenital dyserythropoietic anaemia type I (CDAI) was also present, presumably due to a second deletion in another genomic region. Conclusion: We have identified three families segregating an autosomal recessive contiguous gene deletion syndrome characterised by deafness and sperm dysmotility. This new syndrome is caused by the deletion of contiguous genes at 15q15.3

GJB2 mutations: Passage through Iran

Hereditary hearing loss (HHL) is a very common disorder. When inherited in an autosomal recessive manner, it typically presents as an isolated finding. Interestingly and unexpectedly, in spite of extreme heterogeneity, mutations in one gene, GJB2, are the most common cause of congenital severe-to-profound deafness in many different populations. In this study, we assessed the contributions made by GJB2 mutations and chromosome 13 g.17771792085947del (the deletion more commonly known as del (GJB6-D13S1830) that includes a portion of GJB6 and is hereafter called �(GJB6-D13S1830)) to the autosomal recessive non-syndromic deafness (ARNSD) genetic load in Iran. Probands from 664 different nuclear families were investigated. GJB2-related deafness was found in 111 families (16.7). The carrier frequency of the 35delG mutation showed a geographic variation that is supported by studies in neighboring countries. �(GJB6-B13S1830) was not found. Our prevalence data for GJB2-related deafness reveal a geographic pattern that mirrors the south-to-north European gradient and supports a founder effect in southeastern Europe. © 2005 Wiley-Liss, Inc

Social cognitive processes explain bias in juror decisions

Jury decisions are among the most consequential social decisions in which bias plays a notable role. While courts take measures to reduce the influence of non-evidentiary factors, jurors may still incorporate biases into their decisions. One common bias, crime-type bias, is the extent to which the perceived strength of a prosecutor&rsquo;s case depends on the severity of the crime. Moral judgment, affect and social cognition have been proposed as core processes underlying this and other biases. Behavioral evidence alone has been insufficient to distinguish these explanations. To identify the mechanism underlying crime-type bias, we collected functional magnetic resonance imaging patterns of brain activation from mock jurors reading criminal scenarios. Brain patterns from crime-type bias were most similar to those associated with social cognition (mentalizing and racial bias) but not affect or moral judgment. Our results support a central role for social cognition in juror decisions and suggest that crime-type bias and cultural bias may arise from similar mechanisms. &nbsp;</p