Konsum ökologischer Milch aus gesundheitlichen Gründen - Eine qualitative Erhebung auf deutschen Demeter Milchviehbetrieben und bei ihren Kunden

Supposedly beneficial nutritional compositions were found in organic milk. Studies report that the consumption of organic milk products affects health eg. prevention of eczema in children. Single cases describe a better digestibility of organic milk for consumers suffering from diverse atopic disorders and food allergies. To clarify whether this is a real phenomenon, a survey in combination with interviews was carried out on bio-dynamic milk farms and with affected consumers in Germany. The results show that there are consumers which are buying fresh bio-dynamic raw milk because of a better personal digestibility

Updating ESA's Earth System Model for Gravity Mission Simulation Studies: 3. A Realistically Perturbed Non-Tidal Atmosphere and Ocean De-Aliasing Model

The ability of any satellite gravity mission concept to monitor mass transport processes in the Earth system is typically tested well ahead of its implementation by means of various simulation studies. Those studies often extend from the simulation of realistic orbits and instrumental data all the way down to the retrieval of global gravity field solution time-series. Basic requirement for all these simulations are realistic representations of the spatio-temporal mass variability in the different sub-systems of the Earth, as a source model for the orbit computations. For such simulations, a suitable source model is required to represent (i) high-frequency (i.e., sub-daily to weekly) mass variability in the atmosphere and oceans, in order to realistically include the effects of temporal aliasing due to non-tidal high-frequency mass variability into the retrieved gravity fields. In parallel, (ii) low-frequency (i.e., monthly to interannual) variability needs to be modelled with realistic amplitudes, particularly at small spatial scales, in order to assess to what extent a new mission concept might provide further insight into physical processes currently not observable. The new source model documented here attempts to fulfil both requirements: Based on ECMWF’s recent atmospheric reanalysis ERA-Interim and corresponding simulations from numerical models of the other Earth system components, it offers spherical harmonic coefficients of the time-variable global gravity field due to mass variability in atmosphere, oceans, the terrestrial hydrosphere including the ice-sheets and glaciers, as well as the solid Earth. Simulated features range from sub-daily to multiyear periods with a spatial resolution of spherical harmonics degree and order 180 over a period of 12 years. In addition to the source model, a de-aliasing model for atmospheric and oceanic high-frequency variability with augmented systematic and random noise is required for a realistic simulation of the gravity field retrieval process, whose necessary error characteristics are discussed. The documentation is organized as follows: The characteristics of the updated ESM along with some basic validation are presented in Volume 1 of this report (Dobslaw et al., 2014). A detailed comparison to the original ESA ESM (Gruber et al., 2011) is provided in Volume 2 (Bergmann-Wolf et al., 2014), while Volume 3 (Forootan et al., 2014) contains a description of the strategy to derive a realistically noisy de-aliasing model for the high-frequency mass variability in atmosphere and oceans. The files of the updated ESA Earth System Model for gravity mission simulation studies are accessible at DOI:10.5880/GFZ.1.3.2014.001

Updating ESA's Earth System Model for gravity mission simulation studies: 2. Comparison with the original model

The ability of any satellite gravity mission concept to monitor mass transport processes in the Earth system is typically tested well ahead of its implementation by means of various simulation studies. Those studies often extend from the simulation of realistic orbits and instrumental data all the way down to the retrieval of global gravity field solution time-series. Basic requirement for all these simulations are realistic representations of the spatio-temporal mass variability in the different sub-systems of the Earth, as a source model for the orbit computations. For such simulations, a suitable source model is required to represent (i) high-frequency (i.e., sub-daily to weekly) mass variability in the atmosphere and oceans, in order to realistically include the effects of temporal aliasing due to non-tidal high-frequency mass variability into the retrieved gravity fields. In parallel, (ii) low-frequency (i.e., monthly to interannual) variability needs to be modelled with realistic amplitudes, particularly at small spatial scales, in order to assess to what extent a new mission concept might provide further insight into physical processes currently not observable. The new source model documented here attempts to fulfil both requirements: Based on ECMWF’s recent atmospheric reanalysis ERA-Interim and corresponding simulations from numerical models of the other Earth system components, it offers spherical harmonic coefficients of the time-variable global gravity field due to mass variability in atmosphere, oceans, the terrestrial hydrosphere including the ice-sheets and glaciers, as well as the solid Earth. Simulated features range from sub-daily to multiyear periods with a spatial resolution of spherical harmonics degree and order 180 over a period of 12 years. In addition to the source model, a de-aliasing model for atmospheric and oceanic high-frequency variability with augmented systematic and random noise is required for a realistic simulation of the gravity field retrieval process, whose necessary error characteristics are discussed. The documentation is organized as follows: The characteristics of the updated ESM along with some basic validation are presented in Volume 1 of this report (Dobslaw et al., 2014). A detailed comparison to the original ESA ESM (Gruber et al., 2011) is provided in Volume 2 (Bergmann-Wolf et al., 2014), while Volume 3 (Forootan et al., 2014) contains a description of the strategy to derive a realistically noisy de-aliasing model for the high-frequency mass variability in atmosphere and oceans. The files of the updated ESA Earth System Model for gravity mission simulation studies are accessible at DOI:10.5880/GFZ.1.3.2014.001

Updating ESA's Earth System Model for gravity mission simulation studies: 1. Model description and validation

The ability of any satellite gravity mission concept to monitor mass transport processes in the Earth system is typically tested well ahead of its implementation by means of various simulation studies. Those studies often extend from the simulation of realistic orbits and instrumental data all the way down to the retrieval of global gravity field solution time-series. Basic requirement for all these simulations are realistic representations of the spatio-temporal mass variability in the different sub-systems of the Earth, as a source model for the orbit computations. For such simulations, a suitable source model is required to represent (i) high-frequency (i.e., subdaily to weekly) mass variability in the atmosphere and oceans, in order to realistically include the effects of temporal aliasing due to non-tidal high-frequency mass variability into the retrieved gravity fields. In parallel, (ii) low-frequency (i.e., monthly to interannual) variability needs to be modelled with realistic amplitudes, particularly at small spatial scales, in order to assess to what extent a new mission concept might provide further insight into physical processes currently not observable. The new source model documented here attempts to fulfil both requirements: Based on ECMWF’s recent atmospheric reanalysis ERA-Interim and corresponding simulations from numerical models of the other Earth system components, it offers spherical harmonic coefficients of the time-variable global gravity field due to mass variability in atmosphere, oceans, the terrestrial hydrosphere including the ice-sheets and glaciers, as well as the solid Earth. Simulated features range from sub-daily to multiyear periods with a spatial resolution of spherical harmonics degree and order 180 over a period of 12 years. In addition to the source model, a de-aliasing model for atmospheric and oceanic high-frequency variability with augmented systematic and random noise is required for a realistic simulation of the gravity field retrieval process, whose necessary error characteristics are discussed. The documentation of the updated ESA Earth System Model (updated ESM) for gravity mission simulation studies is organized as follows: The characteristics of the updated ESM along with some basic validation is presented in Volume 1. A detailed comparison to the original ESA ESM (Gruber et al., 2011) is provided in Volume 2, while Volume 3 contains the description of a strategy to derive realistic errors for the de-aliasing model of high-frequency mass variability in atmosphere and ocean

Quaternary structure of the European spiny lobster (Palinurus elephas) 1 x 6-mer hemocyanin from cryoEM and amino acid sequence data

Arthropod hemocyanins are large respiratory proteins that are composed of up to 48 subunits (8 x 6-mer) in the 75 kDa range. A 3D reconstruction of the 1 x 6-mer hemocyanin from the European spiny lobster Palinuris elephas has been performed from 9970 single particles using cryoelectron microscopy. An 8 Angstrom resolution of the hemocyanin 3D reconstruction has been obtained from about 600 final class averages. Visualisation of structural elements such as a-helices has been achieved. An amino acid sequence alignment shows the high sequence identity (>80%.) of the hemocyanin subunits from the European spiny lobster P. elephas and the American spiny lobster Panulirus interruptus. Comparison of the P. elephas hemocyanin electron microscopy (EM) density map with the known P. interruptus X-ray structure shows a close structural correlation, demonstrating the reliability of both methods for reconstructing proteins, By molecular modelling, we have found the putative locations for the amino acid sequence (597-605) and the C-terminal end (654-657), which are absent in the available P. interruptus X-ray data. (C) 2002 Elsevier Science Ltd. All rights reserve

Multivariate Prediction of Total Water Storage Changes Over West Africa from Multi-Satellite Data

West African countries have been exposed to changes in rainfall patterns over the last decades, including a significant negative trend. This causes adverse effects on water resources of the region, for instance, reduced freshwater availability. Assessing and predicting large-scale total water storage (TWS) variations are necessary for West Africa, due to its environmental, social, and economical impacts. Hydrological models, however, may perform poorly over West Africa due to data scarcity. This study describes a new statistical, data-driven approach for predicting West African TWS changes from (past) gravity data obtained from the gravity recovery and climate experiment (GRACE), and (concurrent) rainfall data from the tropical rainfall measuring mission (TRMM) and sea surface temperature (SST) data over the Atlantic, Pacific, and Indian Oceans. The proposed method, therefore, capitalizes on the availability of remotely sensed observations for predicting monthly TWS, a quantity which is hard to observe in the field but important for measuring regional energy balance, as well as for agricultural, and water resource management.Major teleconnections within these data sets were identified using independent component analysis and linked via low-degree autoregressive models to build a predictive framework. After a learning phase of 72 months, our approach predicted TWS from rainfall and SST data alone that fitted to the observed GRACE-TWS better than that from a global hydrological model. Our results indicated a fit of 79 % and 67 % for the first-year prediction of the two dominant annual and inter-annual modes of TWS variations. This fit reduces to 62 % and 57 % for the second year of projection. The proposed approach, therefore, represents strong potential to predict the TWS over West Africa up to 2 years. It also has the potential to bridge the present GRACE data gaps of 1 month about each 162days as well as a—hopefully—limited gap between GRACE and the GRACE follow-on mission over West Africa. The method presented could also be used to generate a near real-time GRACE forecast over the regions that exhibit strong teleconnections

Nanomechanics and Sodium Permeability of Endothelial Surface Layer Modulated by Hawthorn Extract WS 1442

The endothelial glycocalyx (eGC) plays a pivotal role in the physiology of the vasculature. By binding plasma proteins, the eGC forms the endothelial surface layer (ESL) which acts as an interface between bloodstream and endothelial cell surface. The functions of the eGC include mechanosensing of blood flow induced shear stress and thus flow dependent vasodilation. There are indications that levels of plasma sodium concentrations in the upper range of normal and beyond impair flow dependent regulation of blood pressure and may therefore increase the risk for hypertension. Substances, therefore, that prevent sodium induced endothelial dysfunction may be attractive for the treatment of cardiovascular disease. By means of combined atomic force - epifluorescence microscopy we studied the impact of the hawthorn (Crataegus spp.) extract WS 1442, a herbal therapeutic with unknown mechanism of action, on the mechanics of the ESL of ex vivo murine aortae. Furthermore, we measured the impact of WS 1442 on the sodium permeability of endothelial EA.hy 926 cell monolayer. The data show that (i) the ESL contributes by about 11% to the total endothelial barrier resistance for sodium and (ii) WS 1442 strengthens the ESL resistance for sodium up to about 45%. This mechanism may explain some of the vasoprotective actions of this herbal therapeutic

An orbital-free molecular dynamics study of melting in K_20, K_55, K_92, K_142, Rb_55 and Cs_55 clusters

The melting-like transition in potasium clusters K_N, with N=20, 55, 92 and 142, is studied by using an orbital-free density-functional constant-energy molecular dynamics simulation method, and compared to previous theoretical results on the melting-like transition in sodium clusters of the same sizes. Melting in potasium and sodium clusters proceeds in a similar way: a surface melting stage develops upon heating before the homogeneous melting temperature is reached. Premelting effects are nevertheless more important and more easily established in potasium clusters, and the transition regions spread over temperature intervals which are wider than in the case of sodium. For all the sizes considered, the percentage melting temperature reduction when passing from Na to K clusters is substantially larger than in the bulk. Once those two materials have been compared for a number of different cluster sizes, we study the melting-like transition in Rb_55 and Cs_55 clusters and make a comparison with the melting behavior of Na_55 and K_55. As the atomic number increases, the height of the specific heat peaks decreases, their width increases, and the melting temperature decreases as in bulk melting, but in a more pronounced way.Comment: LaTeX file. 6 pages with 17 pictures. Final version with minor change

The usefulness of the electronic patient visit assessment (ePVA) as a clinical support tool for real-time interventions in head and neck cancer

Background: Patients with head and neck cancer (HNC) experience painful, debilitating symptoms and functional limitations that can interrupt cancer treatment, and decrease their health-related quality of life (HRQoL). The Electronic Patient Visit Assessment (ePVA) for head and neck is a web-based mHealth patient-reported measure that asks questions about 21 categories of symptoms and functional limitations common to HNC. This article presents the development and usefulness of the ePVA as a clinical support tool for real-time interventions for patient-reported symptoms and functional limitations in HNC. Methods: Between January 2018 and August 2019, 75 participants were enrolled in a clinical usefulness study of the ePVA. Upon signing informed consent, participants completed the ePVA and the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) general (C30) questionnaire v3.0 (scores range from 0 to 100 with 100 representing best HRQoL). Clinical usefulness of the ePVA was defined as demonstration of reliability, convergent validity with HRQoL, and acceptability of the ePVA (i.e., >70% of eligible participants complete the ePVA at two or more visits and >70% of ePVA reports are read by providers). Formal focus group discussions with the interdisciplinary teamthat cared for patients with HNC guided the development of the ePVA as a clinical support tool. Qualitative and quantitative methods were used throughout the study. Descriptive statistics consisting of means and frequencies, Pearson correlation coefficient, and Student’s t-tests were calculated using SAS 9.4 and STATA. Results: The participants were primarily male (71%), White (76%), diagnosed with oropharyngeal or oralcavity cancers (53%), and undergoing treatment for HNC (69%). Data analyses supported the reliability (alpha =0.85), convergent validity with HRQoL scores, and acceptability of the ePVA. Participants with the highest number of symptoms and functional limitations reported significantly worse HRQoL (sumof symptoms: r=–0.50, P<0.0001; sum of function limitations: r=–0.56, P<0.0001). Ninety-two percent of participants (59 of 64) who had follow-up visits within the 6-month study period completed the ePVA at twoor more visits and providers read 89% (169 of 189) of automated ePVA reports. The use of the ePVA as aclinical support tool for real-time interventions for symptoms and functional limitations reported by patients is described in a clinical exemplar. Conclusions: This research indicates that the ePVA may be a useful mHealth tool as a clinical support tool for real-time interventions for patient-reported symptoms and functional limitations in HNC. The study findings support future translational research to enhance the usefulness of the ePVA in real world settings for early interventions that decrease symptom burden and improve the QoL of patients with HNC