Solar and proxy-sensitivity imprints on paleohydrological records for the last millennium in west-central Europe

International audienceThis paper presents a lake-level record established for the last millennium at Lake Saint-Point in the French Jura Mountains. A comparison of this lake-level record with a solar irradiance record supports the hypothesis of a solar forcing of variations in the hydrological cycle linked to climatic oscillations over the last millennium in west-central Europe, with higher lake levels during the solar minimums of Oort (around AD 1060), Wolf (around AD 1320), Spörer (around AD 1450), Maunder (around AD 1690), and Dalton (around AD 1820). Further comparisons of the Saint-Point record with the fluctuations of the Great Aletsch Glacier (Swiss Alps) and a record of Rhône River floods from Lake Bourget (French Alps) give evidence of possible imprints of proxy sensitivity on reconstructed paleohydrological records. In particular, the Great Aletsch record shows an increasing glacier mass from AD 1350 to 1850, suggesting a cumulative effect of the Little Ice Age cooling and/or a possible reflection of a millennial-scale general cooling until the mid-19th century in the Northern Hemisphere. In contrast, the Saint-Point and Bourget records show a general trend toward a decrease in lake levels and in flood magnitude anti-correlated with generally increasing solar irradiance

Allergenic Shrimp Tropomyosin Distinguishes from a Non-Allergenic Chicken Homolog by Pronounced Intestinal Barrier Disruption and Downstream Th2 Responses in Epithelial and Dendritic Cell (Co)Culture

BACKGROUND: Tropomyosins (TM) from vertebrates are generally non-allergenic, while invertebrate homologs are potent pan-allergens. This study aims to compare the risk of sensitization between chicken TM and shrimp TM through affecting the intestinal epithelial barrier integrity and type 2 mucosal immune activation. METHODS: Epithelial activation and/or barrier effects upon exposure to 2-50 μg/mL chicken TM, shrimp TM or ovalbumin (OVA) as a control allergen, were studied using Caco-2, HT-29MTX, or HT-29 intestinal epithelial cells. Monocyte-derived dendritic cells (moDC), cocultured with HT-29 cells or moDC alone, were exposed to 50 μg/mL chicken TM or shrimp TM. Primed moDC were cocultured with naïve Th cells. Intestinal barrier integrity (TEER), gene expression, cytokine secretion and immune cell phenotypes were determined in these human in vitro models. RESULTS: Shrimp TM, but not chicken TM or OVA exposure, profoundly disrupted intestinal barrier integrity and increased alarmin genes expression in Caco-2 cells. Proinflammatory cytokine secretion in HT-29 cells was only enhanced upon shrimp TM or OVA, but not chicken TM, exposure. Shrimp TM enhanced the maturation of moDC and chemokine secretion in the presence or absence of HT-29 cells, while only in the absence of epithelial cells chicken TM activated moDC. Direct exposure of moDC to shrimp TM increased IL13 and TNFα secretion by Th cells cocultured with these primed moDC, while shrimp TM exposure via HT-29 cells cocultured with moDC sequentially increased IL13 expression and IL4 secretion in Th cells. CONCLUSIONS: Shrimp TM, but not chicken TM, disrupted the epithelial barrier while triggering type 2 mucosal immune activation, both of which are key events in allergic sensitization

Standardization of double blind placebo controlled food challenge with soy within a multicentre trial

Background: Multicentre trials investigating food allergies by double blind placebo controlled food challenges (DBPCFC) need standardized procedures, challenge meals and evaluation criteria. We aimed at developing a standardized approach for identifying patients with birch related soy allergy by means of DBPCFC to soy, including determination of threshold levels, in a multicentre setting. Methods: Microbiologically stable soy challenge meals were composed of protein isolate with consistent Gly m 4 levels. Patients sensitized to main birch allergen Bet v 1 and concomitant sensitization to its soy homologue Gly m 4 underwent DBPCFC. Outcome was defined according to presence and/or absence of ten objective signs and intensity of eight subjective symptoms as measured by visual analogue scale (VAS). Results: 138 adult subjects (63.8% female, mean age 38 years) underwent DBPCFC. Challenge meals and defined evaluation criteria showed good applicability in all centres involved. 45.7% presented with objective signs and 65.2% with subjective symptoms at soy challenge. Placebo challenge meals elicited non-cardiovascular objective signs in 11.6%. In 82 (59.4%) subjects DBPCFC was judged as positive. 70.7% of DPBCFC+ showed objective signs and 85.4% subjective symptoms at soy challenge. Subjective symptoms to soy challenge meal in DBPCFC+ subjects started at significantly lower dose levels than objective signs (p < 0.001). Median cumulative eliciting doses for first objective signs in DBPCFC+ subjects were 4.7 g [0.7–24.7] and 0.7 g [0.2–4.7] total soy protein for first subjective symptoms (p = 0.01). Conclusions: We present the hitherto largest group of adults with Bet v 1 and Gly m 4 sensitization being investigated by DBPCFC. In this type of food allergy evaluation of DBPCFC outcome should not only include monitoring of objective signs but also scoring of subjective symptoms. Our data may contribute to standardize DBPCFC in pollen-related food allergy in multicentre settings. Trial registration EudraCT: 2009-011737-27

Beitrag zur Geschichte des Grossen Aletschgletschers

No abstract available

Neue Ergebnisse zur Gletscher- und Klimageschichte des Spätmittelalters und der Neuzeit

This article contributes to the glacier and climatic fluctuations during the late Middle Ages and the Modern Times. With the aid of radiocarbon dating of fossil woods and a fossil soil (fAh) located in the gletschervorfeld of two glaciers (Glacier de Zinal and Riedgletscher, Valais), the foUowing glacier advances could be shown: between 890 yBP and 1095 yBP, at 515 yBP, in the seventeenth and in the nineteenth Century. The tree rings from a larch (Larix decidua Mill.) near the glacier and the tree line (Riedgletscher, 2180 m altitude) was analysed by the X-ray densitometry. The maximum density of the annual rings reflects the summer temperatures since the middle of the twelfth Century. The fluctuations of the maximum density shows a close interrelation with the fluctuations of the Grosser Aletschgletscher (Valais). The local climatic influence of the Riedgletscher during maximal extension is visible in reduced tree-growth. During the retreat phase, when the glacier melted back, the regional climate dominates the tree-growth again

Neuzeitliche Gletscherschwankungen

No abstract available

Rekonstruktion von Gletscherschwankungen mit Hilfe fossiler Hölzer

Im vorliegenden Artikel wird gezeigt, wie mit Hilfe von fossilen Hölzern aus dem Gletschervorfeld minimale Gletscherausdehnungen und Gletschervorstöße erfaßt werden können. Einige zeitgenössische Berichte und Zeichnungen aus der Zeit um 1850, als die Alpengletscher ihren letzten neuzeitlichen Hochstand erreichten, sollen veranschaulichen, wie Gletscher in bewaldetes Gebiet vordrangen und Bäume umdrückten. Es wird im weiteren kurz auf die Lage von fossilem Holz im Gletschervorfeld und auf ihre wichtigsten Merkmale (guter Erhaltungszustand, Verengung der peripheren Jahrringe, Gletscherschlifl) eingegangen. Ein konstruierter Modellfall veranschaulicht, wie fossiles Holz in situ gletschergeschichtlich ausgewertet werden kann. Als praktisches Beispiel dazu werden die Schwankungen des Großen Aletschgletschers seit 1400 yBP erläutert. Zum ersten Mal überhaupt konnten an einem Gletscher mittelalterliche Gletschervorstöße anhand dendrochronologisch absolut datierter Hölzer jahrgenau erfaßt werden. Ebenso kann mittels solch absoluter Datierungen die Vorstoßphase des Großen Aletschgletschers von 1588 bis 1653 relativ detailliert erfaßt werden

Lichenometric studies on moraines in the Polar Urals

Lichenometry was used to study fluctuations of six glaciers in the Polar Urals over the last millennium (viz: IGAN, Obrucheva, Anuchina, Shumskogo, Avsiuka and Berga glaciers). In order to estimate the growth rate of Rhizocarpon subgenus Rhizocarpon lichens we used recently deglaciated surfaces as calibration sites. These sites, on glacier forelands, were dated using topographic maps, aerial photographs (from 1953, 1958, 1960, 1968, 1973, 1989), terrestrial photogrammetry, field photographs (from the 1960s to 2005), and satellite images (from 2000 and 2008). We also used pits and quarries abandoned between the 1940s–1980s and a road built in the early 1980s as calibration sites. Optimum diametral growth rates of Rhizocarpon subgenus Rhizocarpon are estimated by the new curve to be c. 0.25 mm/year for the last 100 years, assuming linear growth as deduced from the shape of other curves from northern Scandinavia. Due to the lack of old control points we used a reconstructed mass balance curve (from 1816 to 2008) to indirectly constrain the age of pre-twentieth-century moraines. The following moraine groups were identified near the modern fronts of glaciers: ablation moraines de-glaciated during the last 40 to 60 years; lateral moraines formed in the early twentieth century (largest lichen diameter (DLL) = 20 mm), ice-cored moraines, probably from the 1880s (DLL= 24–26 mm); moraines probably deposited in the middle of the nineteenth century and c. 200 years ago (DLL= 30–33 mm and 44–47 mm, respectively); as well as several more ancient moraines (DLL= 70 mm, 90 mm and 110–153 mm) deposited during glacier advances of almost identical extent. According to our tentative lichenometric-age estimates most moraines were formed during the last 450 years – consistent with upper tree-limit altitude variations previously identified for this region. Glacier fluctuations in the Polar Urals are in agreement with tree-ring based reconstructions of summer temperature spanning the last millennium, and are also in tune with glacier behaviour elsewhere in the Northern Hemisphere