Hot-flow tests of a series of 10-percent-scale turbofan forced mixing nozzles

An approximately 1/10-scale model of a mixed-flow exhaust system was tested in a static facility with fully simulated hot-flow cruise and takeoff conditions. Nine mixer geometries with 12 to 24 lobes were tested. The areas of the core and fan stream were held constant to maintain a bypass ratio of approximately 5. The research results presented in this report were obtained as part of a program directed toward developing an improved mixer design methodology by using a combined analytical and experimental approach. The effects of lobe spacing, lobe penetration, lobe-to-centerbody gap, lobe contour, and scalloping of the radial side walls were investigated. Test measurements included total pressure and temperature surveys, flow angularity surveys, and wall and centerbody surface static pressure measurements. Contour plots at various stations in the mixing region are presented to show the mixing effectiveness for the various lobe geometries

Universal persistence exponents in an extremally driven system

The local persistence R(t), defined as the proportion of the system still in its initial state at time t, is measured for the Bak--Sneppen model. For 1 and 2 dimensions, it is found that the decay of R(t) depends on one of two classes of initial configuration. For a subcritical initial state, R(t)\sim t^{-\theta}, where the persistence exponent \theta can be expressed in terms of a known universal exponent. Hence \theta is universal. Conversely, starting from a supercritical state, R(t) decays by the anomalous form 1-R(t)\sim t^{\tau_{\rm ALL}} until a finite time t_{0}, where \tau_{\rm ALL} is also a known exponent. Finally, for the high dimensional model R(t) decays exponentially with a non--universal decay constant.Comment: 4 pages, 6 figures. To appear in Phys. Rev.

Do depressive symptoms predict cancer incidence?: 17-year follow-up of the Whitehall II study

Objective: To explore the association between depressive symptom history and cancer incidence. Methods: Affective/emotional depressive symptoms were assessed using the General Health Questionnaire (GHQ-30) depression sub-scale across phase 1 (1985-1988), phase 2 (1989-1990), and phase 3 (1991-1994) of the Whitehall II prospective cohort study; ‘chronic’= depressive episode at phase 1, 2 and 3; ‘new’= depressive episode at phase 3 only. Cancer Incidence was obtained from the National Health Service Central Register with an average follow-up of 15.6 years (range 0.08–17.4). The study sample consisted of 6983 participants, aged 35–55 years at baseline. Results were adjusted for age, sex, socio-economic position, health behaviours, health status/conditions, medication, and social support. Results: Over a 17.4 year follow-up, chronic depressive symptoms did not increase the risk of cancer incidence compared to those who never experienced symptoms (hazard ratio (HR)=1.03, 95% confidence interval (CI): 0.71-1.49). Participants who experienced new depressive symptoms had an increased risk of cancer incidence in the first 9 years of follow-up (HR=1.89, 95% CI: 1.23-2.90) but no increased risk in later years (HR=0.84, 95% CI: 0.52-1.35). Conclusion: Chronic depressive symptoms were not associated with cancer incidence. In contrast, new-onset symptoms were associated with a substantially increased risk, possibly due to reverse causality

Court Interpreter Training in the Language Laboratory

Demographic studies and statistics from state and federal courts indicate agrowing need for Spanish-English court interpreters with special training in consecutiveand simultaneous court interpretation. The authors conducted a survey of 466 ofCalifornia's Spanish-English court interpreters to determine what the Spanish-Englishcourt interpreter's strongest skills needs are. Survey results are reported in this article,and the five strongest skills training needs are identified. The authors indicate how thelanguage laboratory may efficiently be used to develop and enhance these five skillsand how it may best serve a court interpreter training program. Emphasis is onapplying the work of G.A. Miller and the training techniques of Robert Ingram toSpanish-English court interpreter training

Triumph of hope over experience: learning from interventions to reduce avoidable hospital admissions identified through an Academic Health and Social Care Network.

BACKGROUND: Internationally health services are facing increasing demands due to new and more expensive health technologies and treatments, coupled with the needs of an ageing population. Reducing avoidable use of expensive secondary care services, especially high cost admissions where no procedure is carried out, has become a focus for the commissioners of healthcare. METHOD: We set out to identify, evaluate and share learning about interventions to reduce avoidable hospital admission across a regional Academic Health and Social Care Network (AHSN). We conducted a service evaluation identifying initiatives that had taken place across the AHSN. This comprised a literature review, case studies, and two workshops. RESULTS: We identified three types of intervention: pre-hospital; within the emergency department (ED); and post-admission evaluation of appropriateness. Pre-hospital interventions included the use of predictive modelling tools (PARR - Patients at risk of readmission and ACG - Adjusted Clinical Groups) sometimes supported by community matrons or virtual wards. GP-advisers and outreach nurses were employed within the ED. The principal post-hoc interventions were the audit of records in primary care or the application of the Appropriateness Evaluation Protocol (AEP) within the admission ward. Overall there was a shortage of independent evaluation and limited evidence that each intervention had an impact on rates of admission. CONCLUSIONS: Despite the frequency and cost of emergency admission there has been little independent evaluation of interventions to reduce avoidable admission. Commissioners of healthcare should consider interventions at all stages of the admission pathway, including regular audit, to ensure admission thresholds don't change

A mean field description of jamming in non-cohesive frictionless particulate systems

A theory for kinetic arrest in isotropic systems of repulsive, radially-interacting particles is presented that predicts exponents for the scaling of various macroscopic quantities near the rigidity transition that are in agreement with simulations, including the non-trivial shear exponent. Both statics and dynamics are treated in a simplified, one-particle level description, and coupled via the assumption that kinetic arrest occurs on the boundary between mechanically stable and unstable regions of the static parameter diagram. This suggests the arrested states observed in simulations are at (or near) an elastic buckling transition. Some additional numerical evidence to confirm the scaling of microscopic quantities is also provided.Comment: 9 pages, 3 figs; additional clarification of different elastic moduli exponents, plus typo fix. To appear in PR

The mechanical response of semiflexible networks to localized perturbations

Previous research on semiflexible polymers including cytoskeletal networks in cells has suggested the existence of distinct regimes of elastic response, in which the strain field is either uniform (affine) or non-uniform (non-affine) under external stress. Associated with these regimes, it has been further suggested that a new fundamental length scale emerges, which characterizes the scale for the crossover from non-affine to affine deformations. Here, we extend these studies by probing the response to localized forces and force dipoles. We show that the previously identified nonaffinity length [D.A. Head et al. PRE 68, 061907 (2003).] controls the mesoscopic response to point forces and the crossover to continuum elastic behavior at large distances.Comment: 16 pages, 18 figures; substantial changes to text and figures to clarify the crossover to continuum elasticity and the role of finite-size effect

Memory in aged granular media

Stimulated by recent experimental results, we simulate ``temperature''-cycling experiments in a model for the compaction of granular media. We report on the existence of two types of memory effects: short-term dependence on the history of the sample, and long-term memory for highly compact (aged) systems. A natural interpretation of these results is provided by the analysis of the density heterogeneities.Comment: 5 eps figures, uses euromacr.tex and europhys.sty (included

Caveolin-1 Phosphorylation Is Essential for Axonal Growth of Human Neurons Derived From iPSCs.

Proper axonal growth and guidance is essential for neuron differentiation and development. Abnormal neuronal development due to genetic or epigenetic influences can contribute to neurological and mental disorders such as Down syndrome, Rett syndrome, and autism. Identification of the molecular targets that promote proper neuronal growth and differentiation may restore structural and functional neuroplasticity, thus improving functional performance in neurodevelopmental disorders. Using differentiated human neuronal progenitor cells (NPCs) derived from induced pluripotent stem cells (iPSCs), the present study demonstrates that during early stage differentiation of human NPCs, neuron-targeted overexpression constitutively active Rac1 (Rac1CA) and constitutively active Cdc42 (Cdc42CA) enhance expression of P-Cav-1, T-Cav-1, and P-cofilin and increases axonal growth. Similarly, neuron-targeted over-expression of Cav-1 (termed SynCav1) increases axonal development by increasing both axon length and volume. Moreover, inhibition of Cav-1(Y14A) phosphorylation blunts Rac1/Cdc42-mediated both axonal growth and differentiation of human NPCs and SynCav1(Y14A)-treated NPCs exhibited blunted axonal growth. These results suggest that: (1) SynCav1-mediated dendritic and axonal growth in human NPCs is dependent upon P-Cav-1, (2) P-Cav-1 is necessary for proper axonal growth during early stages of neuronal differentiation, and (3) Rac1/Cdc42CA-mediated neuronal growth is in part dependent upon P-Cav-1. In conclusion, Cav-1 phosphorylation is essential for human neuronal axonal growth during early stages of neuronal differentiation