Using Systems Analysis to Forecast Labor Force Participation by Age, Sex, and Educational Attainment in Egypt to 2051

Egypt population size has rapidly increased during the past decades to about 87 million inhabitants in 2014. Egypt will only be able to cope with its population-development challenges if it manages to significantly advance its economic development and slow population growth, where an emphasis on human capital formation (education) is likely to be a key factor. The working-age population (15-64) represents about 64% of the total population. However, only 50% of this age-group is engaged in the labor force; and more than 20% is illiterate, this percentage is even higher among women of working age (30%), which explains their low participation in the formal labor force: only 24%. This paper aims to forecast labor force in Egypt not only by age, sex but also by level of educational attainment, considering education as an important element to enhance labor force participation regardless of its size. Taking into account the continued population growth, the demographic window of opportunity will be flat and long for Egypt, this paper tries to answer the question regarding the ability to “catch it” and benefit from having a large young labor force. This paper is an extension of the work done by Goujon et al. (2007) on human capital (multistate) projections to 2051 in which we developed projections of the Egyptian population by sex, age, and level of educational attainment (including the provincial level). In the presentation we combine these with future scenarios on the rates of participation of the labor force by age, sex, and level of educational attainment at the national level. A better educated even if growing labor force is likely to be able to lessen some of the expected economic consequences of population growth

Population and Human Capital Growth in Egypt: Projections for Governorates to 2051

Human capital formation has been chosen as the initial focal point of this new IIASA population-development-environment case study on Egypt. With its population still likely to double and its water resources severely restricted, Egypt faces formidable population- and environment-related challenges. The government has an explicit population policy aimed at bringing the fertility rate down to replacement level by 2017. With its options for agricultural development severely limited, the future livelihood of this rapidly growing population can only be secured through rapid development in the industrial and service sectors. For both sectors, human capital development is a necessary prerequisite for success. Of course, such development needs to be complemented by the right investment and trade policies. But without a sufficiently well-educated population, Egypt will not be able to compete in the global service and industry markets. The study explores the human capital dimension at the aggregate level for the whole of Egypt and at the governorate level, distinguishing between 21 governorates and the Frontier Region. For each of the governorates a multi-state population projection model is defined that differentiates the population by age, sex, and level of education. The scenarios demonstrate the momentum of educational development: The challenges will be important for those governorates where past investments in education have been insufficient, especially for the female population, and where the working-age population will increase tremendously, such as in Fayoum, Menia, Assyout, and Suhag. The projections point to the necessity of major structural changes in the development of Egypt

Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in Fundulus heteroclitus

Widespread contamination of aquatic systems with polycyclic aromatic hydrocarbons (PAHs) has led to concern about effects of PAHs on aquatic life. Some PAHs have been shown to cause deformities in early life stages of fish that resemble those elicited by planar halogenated aromatic hydrocarbons (pHAHs) that are agonists for the aryl hydrocarbon receptor (AHR). Previous studies have suggested that activity of cytochrome P4501A, a member of the AHR gene battery, is important to the toxicity of pHAHs, and inhibition of CYP1A can reduce the early-life-stage toxicity of pHAHs. In light of the effects of CYP1A inhibition on pHAH-derived toxicity, we explored the impact of both model and environmentally relevant CYP1A inhibitors on PAH-derived embryotoxicity. We exposed Fundulus heteroclitus embryos to two PAH-type AHR agonists, β-naphthoflavone and benzo(a)pyrene, and one pHAH-type AHR agonist, 3,3′,4,4′,5-pentachlorobiphenyl (PCB-126), alone and in combination with several CYP1A inhibitors. In agreement with previous studies, coexposure of embryos to PCB-126 with the AHR antagonist and CYP1A inhibitor α-naphthoflavone decreased frequency and severity of deformities compared with embryos exposed to PCB-126 alone. In contrast, embryos coexposed to the PAHs with each of the CYP1A inhibitors tested were deformed with increased severity and frequency compared with embryos dosed with PAH alone. The mechanism by which inhibition of CYP1A increased embryotoxicity of the PAHs tested is not understood, but these results may be helpful in elucidating mechanisms by which PAHs are embryotoxic. Additionally, these results call into question additive models of PAH embryotoxicity for environmental PAH mixtures that contain both AHR agonists and CYP1A inhibitors

A Unified Theoretical Description of the Thermodynamical Properties of Spin Crossover with Magnetic Interactions

After the discovery of the phenomena of light-induced excited spin state trapping (LIESST), the functional properties of metal complexes have been studied intensively. Among them, cooperative phenomena involving low spin-high spin (spin-crossover) transition and magnetic ordering have attracted interests, and it has become necessary to formulate a unified description of both phenomena. In this work, we propose a model in which they can be treated simultaneously by extending the Wajnflasz-Pick model including a magnetic interaction. We found that this new model is equivalent to Blume-Emery-Griffiths (BEG) Hamiltonian with degenerate levels. This model provides a unified description of the thermodynamic properties associated with various types of systems, such as spin-crossover (SC) solids and Prussian blue analogues (PBA). Here, the high spin fraction and the magnetization are the order parameters describing the cooperative phenomena of the model. We present several typical temperature dependences of the order parameters and we determine the phase diagram of the system using the mean-field theory and Monte Carlo simulations. We found that the magnetic interaction drives the SC transition leading to re-entrant magnetic and first-order SC transitions.Comment: 30pages, 11figure

PSI-Search: iterative HOE-reduced profile SSEARCH searching

Summary: Iterative similarity searches with PSI-BLAST position-specific score matrices (PSSMs) find many more homologs than single searches, but PSSMs can be contaminated when homologous alignments are extended into unrelated protein domains—homologous over-extension (HOE). PSI-Search combines an optimal Smith–Waterman local alignment sequence search, using SSEARCH, with the PSI-BLAST profile construction strategy. An optional sequence boundary-masking procedure, which prevents alignments from being extended after they are initially included, can reduce HOE errors in the PSSM profile. Preventing HOE improves selectivity for both PSI-BLAST and PSI-Search, but PSI-Search has ~4-fold better selectivity than PSI-BLAST and similar sensitivity at 50% and 60% family coverage. PSI-Search is also produces 2- for 4-fold fewer false-positives than JackHMMER, but is ~5% less sensitive

Is children’s education associated with parental health? Evidence from the Philippines

This study examines the association between children’s education and parental health using data from the 2007 Philippine Study on Ageing. It employs a broad, more comprehensive, definition of health to capture the different health dimensions. By employing multiple indicators of health, this study is able to examine whether the influence of children's education is consistent across different health indicators. It also investigates whether parental behavior and receipt of support from children serve as pathways that mediate the relationship between children’s education and parental health. Findings show that older women whose children completed tertiary education have lower odds of reporting IADL or ADL difficulty compared with their counterparts whose children attained below tertiary education. These findings contribute to the growing evidence that education is not only an individual resource; rather it could be a household or family resource that could benefit other family members

A new bioinformatics analysis tools framework at EMBL–EBI

The EMBL-EBI provides access to various mainstream sequence analysis applications. These include sequence similarity search services such as BLAST, FASTA, InterProScan and multiple sequence alignment tools such as ClustalW, T-Coffee and MUSCLE. Through the sequence similarity search services, the users can search mainstream sequence databases such as EMBL-Bank and UniProt, and more than 2000 completed genomes and proteomes. We present here a new framework aimed at both novice as well as expert users that exposes novel methods of obtaining annotations and visualizing sequence analysis results through one uniform and consistent interface. These services are available over the web and via Web Services interfaces for users who require systematic access or want to interface with customized pipe-lines and workflows using common programming languages. The framework features novel result visualizations and integration of domain and functional predictions for protein database searches. It is available at http://www.ebi.ac.uk/Tools/sss for sequence similarity searches and at http://www.ebi.ac.uk/Tools/msa for multiple sequence alignments

Collective effects in spin-crossover chains with exchange interaction

The collective properties of spin-crossover chains are studied. Spin-crossover compounds contain ions with a low-spin ground state and low lying high-spin excited states and are of interest for molecular memory applications. Some of them naturally form one-dimensional chains. Elastic interaction and Ising exchange interaction are taken into account. The transfer-matrix approach is used to calculate the partition function, the fraction of ions in the high-spin state, the magnetization, susceptibility, etc., exactly. The high-spin-low-spin degree of freedom leads to collective effects not present in simple spin chains. The ground-state phase diagram is mapped out and compared to the case with Heisenberg exchange interaction. The various phases give rise to characteristic behavior at nonzero temperatures, including sharp crossovers between low- and high-temperature regimes. A Curie-Weiss law for the susceptibility is derived and the paramagnetic Curie temperature is calculated. Possible experiments to determine the exchange coupling are discussed.Comment: 9 pages, 13 color figures, published versio

Spectrum of Kidney Involvement in Patients with Myelodysplastic Syndromes.

Myelodysplastic syndromes (MDS) are characterized by a high prevalence of associated autoimmune manifestations. Kidney involvement has been rarely reported in MDS patients. We report on the spectrum of kidney pathological findings in MDS patients. We retrospectively identified MDS patients who had undergone a kidney biopsy between 2001 and 2019 in nine Swiss and French nephrology centres. Nineteen patients (median age 74 years [63-83]) were included. At the time of kidney biopsy, eleven (58%) patients had extra-renal auto-immune manifestations and sixteen (84%) presented with acute kidney injury. Median serum creatinine at diagnosis was 2.8 mg/dL [0.6-8.3] and median urinary protein to creatinine ratio was 1.2 g/g [0.2-11]. Acute tubulo-interstitial nephritis (TIN) was present in seven (37%) patients. Immunofluorescence study in one patient with acute TIN disclosed intense IgG deposits along the tubular basement membrane and Bowman's capsule. Other kidney pathological features included ANCA-negative pauci-immune necrotizing and crescentic glomerulonephritis (n = 3), membranous nephropathy (n = 2), IgA nephropathy (n = 1), IgA vasculitis (n = 1), immunoglobulin-associated membrano-proliferative glomerulonephritis type I (n=1), crescentic C3 glomerulopathy (n = 1), fibrillary glomerulonephritis (n = 1) and minimal change disease (n = 1). Eleven (58%) patients received immunosuppressive treatments, among whom one developed a severe infectious complication. After a median follow-up of 7 month [1-96], nine (47%) patients had chronic kidney disease stage 3 (n = 6) or 4 (n = 3) and five (26%) progressed to end-stage kidney disease. Three patients died. MDS are associated to several autoimmune kidney manifestations, predominantly acute TIN. MDS are to be listed among the potential causes of autoimmune TIN