Perilaku Masyarakat dalam Pengelolaan Kesehatan Lingkungan (Studi di Desa Segiguk sebagai Salah Satu Desa Penyangga Kawasan Hutan Suaka Margasatwa Gunung Raya Ogan Komering Ulu Selatan)

Penelitian ini bertujuan untuk menganilisis tentang pengelolaan lingkungan pemukiman di salah satu desa penyangga kawasan Hutan Suaka Margasatwa Gunung Raya. Penelitian ini juga bertujuan untuk mengetahui partisipasi masyarakat dalam mengelola dan mempertahankan kualitas lingkungan kawasan yang dilindungi pemerintah. Selain itu, permasalahan kesehatan yang berpotensial terjadi di wilayah tersebut , akibat pengelolaan lingkungan, juga menjadi perhatian pada penelitian ini. Penelitian ini merupakan penelitian studi kasus dengan metode penelitian deskriptif kualitatif. Parameter yang diamati adalah bentuk partisipasi masyarakat dalam pengelolaan lingkungan sehat terhadap penggunaan air bersih, struktur rumah sehat, keluarga dengan kepemilikan sarana sanitasi dasar dan tenpat umum dan pengelolaan makanan.Bentuk partisipasi tersebut dapat diamati pada perilaku masyarakat yang merupakan implementasi dari persepsi dan pemahaman masyarakat mengenai hal tersebut

Integrated microfossil biostratigraphy, facies distribution, and depositional sequences of the upper Turonian to Campanian succession in northeast Egypt and Jordan

Six upper Turonian to Campanian sections in Egypt (Sinai) and Jordan were studied for their microfossil biostratigraphy (calcareous nannofossils and planktonic foraminifera), facies distribution and sequence stratigraphic frameworks. Carbonate (mostly chalk) and chert lithofacies dominate the basinward northern sections passing laterally and vertically to mixed carbonate/siliciclastic lithofacies towards the shoreline in the southeast. Twenty-six lithofacies types have been identified and grouped into six lithofacies associations: littoral siliciclastic facies belt; peritidal carbonate; intertidal carbonate platform/ramp; high-energy ooidal shoals and shelly biostromes; shallow subtidal; and pelagic facies association. The following calcareous nannofossil biozones were recognized: Luianorhabdus malefomis (CC12) (late Turonian), Micula staurophora (CC14) (early Coniacian), Reinhardtites anthophorus (CC15) (late Coniacian), Lucianorhabdus cayeuxii (CC16) (early Santonian) and Broinsonia parca parca (CC18) (Campanian). Equivalent planktonic foraminifera zones recognized are: Dicarinella concavata (Coniacian), the lower most part of Dicarinella asymetrica (earliest Santonian) and Globotruncanita elevata (early Campanian). The integrated zonation presented here is considered to provide higher resolution than the use of either group alone. The absence of calcareous nannofossil biozones CC13 and CC17 in most of the studied sections, associated with regional vertical lithofacies changes, indicates that recognition of the Turonian/Coniacian and Santonian/Campanian stage boundary intervals in the region have been hampered by depositional hiatuses at major sequence boundaries resulting in incomplete sections. These disconformities are attributed to eustatic sea-level fluctuations and regional tectonics resulting from flexuring of the Syrian Arc fold belt. The Coniacian to Santonian succession can be divided into three third-order depositional sequences, which are bounded by four widely recognized sequence boundaries

New microplanktonic biostratigraphy and depositional sequences across the Middle-Late Eocene and Oligocene boundaries in eastern Jordan

The first detailed calcareous nannofossil and planktonic foraminiferal biostratigraphic and integrated lithofacies analyses of the Eocene–Oligocene transition at the Qa’ Faydat ad Dahikiya area in the Eastern Desert of Jordan, on the border with Saudi Arabia, is presented. Three calcareous nannofossil zones namely: Discoaster saipanensis (NP17), Chiasmolithus oamaruensis (NP18) and Ericsonia subdisticha (NP21), and three planktonic foraminiferal zones: upper part of Truncorotaloides rohri (E13), Globigerinatheka semiinvoluta (E14) and Cassigerinella chipolensis/ Pseudohastigerina micra (O1) are identified. Calcareous nannofossil bioevents recorded in the present study show numerous discrepancies with the Standard biostratigraphic zonal schemes to detect the Middle/Upper Eocene boundary (e.g. the highest occurrences (HOs) of Chiasmolithus solitus, C. grandis, and lowest occurrences (LOs) of C. oamaruensis, Isthmolithus recurvus are not considered reliable markers for global correlation). The Middle/Upper Eocene boundary occurs in the current study above the extinctions of large muricate planktonic foraminifera (large Acarinina and Truncorotaloides spp.) which coincide within the equivalent calcareous nannofossil NP18 Zone. These microplanktonic bioevents seem to constitute more reliable markers for the base of the Upper Eocene in different provinces. The uppermost portion of the Middle Eocene is characterized by an observed drop in faunal content and, most likely, primarily denotes the effect of the major fall in eustatic sea level. A major unconformity (disconformity) marked by a mineralized hardground representing a lowstand is recorded in the present study at the Eocene–Oligocene transition that reveals an unexpected ca. 2.1 Myr duration, separating Eocene (NP18/E14 zones) from Oligocene (NP21/O1 zones). Furthermore, the microfossil turnover associated with a rapid decline of the microfossil assemblages shows a distinct drop in diversity and abundance towards the Eocene/Oligocene unconformity and is associated with a sharp lithological break marked, at the base, by a mineralized hardground representing a major sequence boundary. These bioevents, depositional sequences and the depositional hiatus correlate well with different parts of the Arabian and African plates, but the magnitude of the faunal break differs from place to place as a result of intraplate deformation during the regional Oligocene regression of Neo-Tethys on the northern Arabian Plate. The presence of the Lower Oligocene shallow-marine calcareous planktonic assemblages in the study area indicate that communication between the eastern and western provinces of the western Neo-Tethys region still existed at this time

The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs

A controlled inflammatory response is required for protection against infection, but persistent inflammation causes tissue damage. Dendritic cells (DCs) have a unique capacity to promote both inflammatory and anti-inflammatory processes. One key mechanism involved in DC-mediated immunosuppression is the expression of tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase (IDO). IDO has been implicated in diverse processes in health and disease but its role in endotoxin tolerance in human DCs is still controversial. Here we investigated the role of IDO in shaping DCs phenotype and function under endotoxin tolerance conditions. Our data show that TLR4 ligation in LPS-primed DCs, induced higher levels of both IDO isoforms together with the transcription factor aryl-hydrocarbon receptor (AhR), compared to unprimed controls. Additionally, LPS conditioning induced an anti-inflammatory phenotype in DCs - with an increase in IL-10 and higher expression of programmed death ligand (PD-L)1 and PD-L2 - which were partially dependent on IDO. Furthermore, we demonstrated that the AhR-IDO pathway was responsible for the preferential activation of noncanonical NF-κB pathway in LPS-conditioned DCs. These data provide new insight into the mechanisms of the TLR4-induced tolerogenic phenotype in human DCs, which can help the better understanding of processes involved in induction and resolution of chronic inflammation and tolerance

In search of the right literature search engine(s)

*Background*
Collecting scientific publications related to a specific topic is crucial for different phases of research, health care and ‘effective text mining’. Available bio-literature search engines vary in their ability to scan different sections of articles, for the user-provided search terms and/or phrases. Since a thorough scientific analysis of all major bibliographic tools has not been done, their selection has often remained subjective. We have considered most of the existing bio-literature search engines (http://www.shodhaka.com/startbioinfo/LitSearch.html) and performed an extensive analysis of 18 literature search engines, over a period of about 3 years. Eight different topics were taken and about 50 searches were performed using the selected search engines. The relevance of retrieved citations was carefully assessed after every search, to estimate the citation retrieval efficiency. Different other features of the search tools were also compared using a semi-quantitative method.
*Results*
The study provides the first tangible comparative account of relative retrieval efficiency, input and output features, resource coverage and a few other utilities of the bio-literature search tools. The results show that using a single search tool can lead to loss of up to 75% relevant citations in some cases. Hence, use of multiple search tools is recommended. But, it would also not be practical to use all or too many search engines. The detailed observations made in the study can assist researchers and health professionals in making a more objective selection among the search engines. A corollary study revealed relative advantages and disadvantages of the full-text scanning tools.
*Conclusion*
While many studies have attempted to compare literature search engines, important questions remained unanswered till date. Following are some of those questions, along with answers provided by the current study:
a)	Which tools should be used to get the maximum number of relevant citations with a reasonable effort? ANSWER: _Using PubMed, Scopus, Google Scholar and HighWire Press individually, and then compiling the hits into a union list is the best option. Citation-Compiler (http://www.shodhaka.com/compiler) can help to compile the results from each of the recommended tool._
b)	What is the approximate percentage of relevant citations expected to be lost if only one search engine is used? ANSWER: _About 39% of the total relevant citations were lost in searches across 4 topics; 49% hits were lost while using PubMed or HighWire Press, while 37% and 20% loss was noticed while using Google Scholar and Scopus, respectively._ 
c)	Which full text search engines can be recommended in general? ANSWER: _HighWire Press and Google Scholar._
d)	Among the mostly used search engines, which one can be recommended for best precision? ANSWER: _EBIMed._
e)	Among the mostly used search engines, which one can be recommended for best recall? ANSWER: _Depending on the type of query used, best recall could be obtained by HighWire Press or Scopus.

Tuberculous endocarditis: valvular and right atrial involvement

Valvular endocarditis due to Mycobacterium tuberculosis is a rare clinical entity. It is usually manifest in the context of disseminated tuberculosis in immunocompromised Patients. This report describes a unique case of a 30-year-old immunocompetent man with an incidental finding of tuberculous valvular endocarditis. The Patient had a large mass on the anterior mitral leaflet and severe mitral regurgitation. He underwent mitral valve replacement and Mycobacterium tuberculosis was cultured from the valve vegetation and the right atrial masses. Post-operative recovery has been uneventful without relapse for 24 months