Age constraints for the Trachilos footprints from Crete.

We present an updated time frame for the 30 m thick late Miocene sedimentary Trachilos section from the island of Crete that contains the potentially oldest hominin footprints. The section is characterized by normal magnetic polarity. New and published foraminifera biostratigraphy results suggest an age of the section within the Mediterranean biozone MMi13d, younger than ~ 6.4 Ma. Calcareous nannoplankton data from sediments exposed near Trachilos and belonging to the same sub-basin indicate deposition during calcareous nannofossil biozone CN9bB, between 6.023 and 6.727 Ma. By integrating the magneto- and biostratigraphic data we correlate the Trachilos section with normal polarity Chron C3An.1n, between 6.272 and 6.023 Ma. Using cyclostratigraphic data based on magnetic susceptibility, we constrain the Trachilos footprints age at ~ 6.05 Ma, roughly 0.35 Ma older than previously thought. Some uncertainty remains related to an inaccessible interval of ~ 8 m section and the possibility that the normal polarity might represent the slightly older Chron C3An.2n. Sediment accumulation rate and biostratigraphic arguments, however, stand against these points and favor a deposition during Chron C3An.1n

Palynological, Palynofacies, Paleoenvironmental and Organic Geochemical Studies on the Upper Cretaceous Succession of the GPTSW-7 Well, North Western Desert, Egypt

The present study of the Abu Roash and Bahariya formations in well GPTSW-7 refines our understanding of the subsurface Cretaceous of the north Western Desert of Egypt. Our investigations are based on the palynological analyses of 71 cuttings samples, of which 24 have also been analyzed for geochemistry, in addition to 3 sidewall cores analyzed for vitrinite reflectance (Ro). Four palynological zones and three subzones in addition to a poorly fossiliferous interval ranging in age from Coniacian-Santonian to early Cenomanian are proposed. These include a poorly fossiliferous interval (Coniacian-Santonian), Dinogymnium vozzhennikovae Interval Zone (late to middle Turonian), Ephedripites ambiguus-Ephedripites multicostatus-Foveotricolpites giganteus-Foveotricolpites gigantoreticultus Assemblage Zone (early Turonian), Classopollis brasiliensis Interval Zone (late to middle Cenomanian), and Afropollis jardinus Interval Zone (early Cenomanian). The succeeding subzones are; Afropollis kahramanensis Interval Subzone, Elaterosporites klaszii Interval Subzone and Cretacaeiporites densimurus Interval Subzone, all of early Cenomanian age. Total organic carbon (TOC) and Rock-Eval pyrolysis and palynofacies analyses indicate that the Bahariya Formation and the Abu Roash G Member are primarily of kerogen III type and hence gas prone, suggesting a strong influence of hydrogen-enriched organic matter. The Abu Roash A, C-E Members may also be gas prone (type III kerogen) and appear to contain highly oxidized terrestrial organic matter. In contrast, the Abu Roash F Member has very high TOC and HI values and contains a very high proportion of amorphous organic matter (AOM) indicating a highly oil-prone facies. While this finding is not unexpected for anoxic black shale, it contrasts with earlier studies that suggest a gas prone nature. Ro measurements show that the Bahariya Formation represents an immature-early genesis dry gas phase. This is also true for all investigated samples from the Abu Roash and Bahariya formations, based on their low thermal alteration index (TAI). Quantitative and qualitative analyses of both the palynoflora and palynofacies show that the Abu Roash A and C Members (B is missing), both of Coniacian-Santonian age, represent oxic proximal and distal shelf environment. The Abu Roash D and E Members, dated as Turonian, represent oxic (proximal) shelf, whereas the Cenomanian Abu Roash F Member was deposited in a distal suboxic-anoxic basin. The Cenomanian Abu Roash G Member and the Bahariya Formation were deposited in a shallow marine and shallow marine to fluvio-deltaic setting, respectively. The Senonian Palmae Province is recognized in the palynoflora by the presence of Proteacidites, Auriculiidites reticulatus, Ariadnaesporites, Gabonisporis vigourouxii. On the other hand the Albian-Cenomanian Elaterates Province is characterized by the presence of Steevesipollenites, Gnetaceaepollenites, Elaterocolpites, Elaterosporites, Elateroplicites, Senegalosporites, Sofrepites, Afropollis and Cretacaeiporites

Prognostic Significance of Survivin in Pediatric Acute Lymphoblastic Leukemia

Impaired apoptosis is mediated by members of the inhibitor of apoptosis proteins (IAP) family such as survivin. Survivin was described in number of different tumors and found to correlate with poor prognosis in a variety of cancers including hematologic malignancies. The aim of this study was to determine survivin in pediatric ALL and compare it with clinical and hematological findings, response to therapy and outcome. Flowcytometry was used for detection of intracellular survivin and determine its mean fluorescence intensity (MFI) in bone marrow mononuclear cells. Patients were followed up for 28 months after induction therapy. Survivin was detected in 63.3% of the patients BM. In spite of no association of survivin levels with established risk factors (P > 0.05) except with high WBC, there was significant higher level of survivin expression in high risk group patients when patients were stratified into high and standard risk groups. According to response to induction therapy, there was no significant difference, in survivin level between patients who achieved CR, RD and ED. However, patients suffering relapse of the disease, had a significant higher basal level of survivin than patients still in remission. Over expression of survivin is a candidate parameter to determine poor prognosis in ALL patients and it may serve to refine treatment stratification with intensification of therapy in those patients prone to relapse