Management of erectile dysfunction post-radical prostatectomy

© 2015 Saleh et al.Radical prostatectomy is a commonly performed procedure for the treatment of localized prostate cancer. One of the long-term complications is erectile dysfunction. There is little consensus on the optimal management; however, it is agreed that treatment must be prompt to prevent fibrosis and increase oxygenation of penile tissue. It is vital that patient expectations are discussed, a realistic time frame of treatment provided, and treatment started as close to the prostatectomy as possible. Current treatment regimens rely on phosphodiesterase 5 inhibitors as a first-line therapy, with vacuum erection devices and intraurethral suppositories of alprostadil as possible treatment combination options. With nonresponders to these therapies, intracavernosal injections are resorted to. As a final measure, patients undergo the highly invasive penile prosthesis implantation. There is no uniform, objective treatment program for erectile dysfunction post-radical prostatectomy. Management plans are based on poorly conducted and often underpowered studies in combination with physician and patient preferences. They involve the aforementioned drugs and treatment methods in different sequences and doses. Prospective treatments include dietary supplements and gene therapy, which have shown promise with there proposed mechanisms of improving erectile function but are yet to be applied successfully in human patients

A delay-dependent approach to H∞ filtering for stochastic delayed jumping systems with sensor non-linearities

This is the post print version of the article. The official published version can be obtained from the link below - Copyright 2007 Taylor & Francis Ltd.In this paper, a delay-dependent approach is developed to deal with the stochastic H∞ filtering problem for a class of It type stochastic time-delay jumping systems subject to both the sensor non-linearities and the exogenous non-linear disturbances. The time delays enter into the system states, the sensor non-linearities and the external non-linear disturbances. The purpose of the addressed filtering problem is to seek an H∞ filter such that, in the simultaneous presence of non-linear disturbances, sensor non-linearity as well as Markovian jumping parameters, the filtering error dynamics for the stochastic time-delay system is stochastically stable with a guaranteed disturbance rejection attenuation level γ. By using It's differential formula and the Lyapunov stability theory, we develop a linear matrix inequality approach to derive sufficient conditions under which the desired filters exist. These conditions are dependent on the length of the time delay. We then characterize the expression of the filter parameters, and use a simulation example to demonstrate the effectiveness of the proposed results.This work was supported in part by the Engineering and Physical Sciences Research Council (EPSRC) of the U.K. under Grant GR/S27658/01, the Nuffield Foundation of the U.K.under Grant NAL/00630/G, and the Alexander von Humboldt Foundation of Germany

On the exponential stability of stochastic Markovian jump systems

This paper deals with the exponential stability of the class of stochastic systems with jumps. For the linear case, a sufficient condition, which guarantees that the nominal system with a bounded diffusion term remains stable under a state feedback control law, is established. For the case of uncertain linear stochastic system, we have designed an optimal control law that guarantees the robust exponential stability of the systems. Finally, for the nonlinear case with matching conditions, we have established a similar result.published_or_final_versio

Resistivity due to low-symmetrical defects in metals

The impurity resistivity, also known as the residual resistivity, is calculated ab initio using multiple-scattering theory. The mean-free path is calculated by solving the Boltzmann equation iteratively. The resistivity due to low-symmetrical defects, such as an impurity-vacancy pair, is calculated for the FCC host metals Al and Ag and the BCC transition metal V. Commonly, 1/f noise is attributed to the motion of such defects in a diffusion process.Comment: 24 pages in REVTEX-preprint format, 10 Postscript figures. Phys. Rev. B, vol. 57 (1998), accepted for publicatio

Theory for the electromigration wind force in dilute alloys

A multiple scattering formulation for the electromigration wind force on atoms in dilute alloys is developed. The theory describes electromigration via a vacancy mechanism. The method is used to calculate the wind valence for electromigration in various host metals having a close-packed lattice structure, namely aluminum, the noble metals copper, silver and gold and the $4d$ transition metals. The self-electromigration results for aluminum and the noble metals compare well with experimental data. For the $4d$ metals small wind valences are found, which make these metals attractive candidates for the experimental study of the direct valence.Comment: 18 pages LaTeX, epsfig, 8 figures. to appear in Phys. Rev. B 56 of 15/11/199

Iterative maximum-likelihood reconstruction in quantum homodyne tomography

I propose an iterative expectation maximization algorithm for reconstructing a quantum optical ensemble from a set of balanced homodyne measurements performed on an optical state. The algorithm applies directly to the acquired data, bypassing the intermediate step of calculating marginal distributions. The advantages of the new method are made manifest by comparing it with the traditional inverse Radon transformation technique

An action principle for the quantization of parametric theories and nonlinear quantum cosmology

By parametrizing the action integral for the standard Schrodinger equation we present a derivation of the recently proposed method for quantizing a parametrized theory. The reformulation suggests a natural extension from conventional to nonlinear quantum mechanics. This generalization enables a unitary description of the quantum evolution for a broad class of constrained Hamiltonian systems with a nonlinear kinematic structure. In particular, the new theory is applicable to the quantization of cosmological models where a chosen gravitational degree of freedom acts as geometric time. This is demonstrated explicitly using three cosmological models: the Friedmann universe with a massless scalar field and Bianchi type I and IX models. Based on these investigations, the prospect of further developing the proposed quantization scheme in the context of quantum gravity is discussed.Comment: 14 page

A combined continuous and interval aerobic training improves metabolic syndrome risk factors in men.

Individuals with metabolic syndrome have significantly higher risk for cardiovascular disease, Type 2 diabetes leading to premature death mortality. Metabolic syndrome has a complex aetiology, thus it may require a combined and multi-targeted aerobic exercise regimen to improve risk factors associated with the metabolic syndrome. Therefore, the aim of this study was to evaluate the effect of combined continuous and interval aerobic training on patients with metabolic syndrome. Thirty adult male with metabolic syndrome (54±8 years) were randomly divided into two groups: Test Training Group (TTG; n=15) or Control Group (CG; n=15). Subjects in TTG group performed combined continuous and interval aerobic training using a motorised treadmill three times per week for 16 weeks. Subjects in CG group were advised to continue with their normal activities of life. Twenty-two men completed the study (11 men in each group). At the end of the study, in TTG group, there were significant (for all, P<0.05) reductions in total body weight (-3.2%), and waist circumference (-3.43 cm), blood pressure (BP; up to -12.7 mmHg), plasma insulin, glucose and triacylglycerides levels. Moreover, there were significant (for all, P<0.05) increases in VO2max (-15.3%) and isometric strength of thigh muscle (28.1%) and HDL in TTG group. None of the above indices were changed in CG group at the end of 16 week study period. Our study suggests that adoption of a 16 week combined continuous and interval aerobic training regimen in men with metabolic syndrome could significantly reduce cardiovascular risk factors in these patients

Quantum field theoretic approach to neutrino oscillations in matter

We consider neutrino oscillations in non-uniform matter in a quantum field theoretic (QFT) approach, in which neutrino production, propagation and detection are considered as a single process. We find the conditions under which the oscillation probability can be sensibly defined and demonstrate how the properly normalized oscillation probability can be obtained in the QFT framework. We derive the evolution equation for the oscillation amplitude and discuss the conditions under which it reduces to the standard Schr\"odinger-like evolution equation. It is shown that, contrary to the common usage, the Schr\"odinger-like evolution equation is not applicable in certain cases, such as oscillations of neutrinos produced in decays of free pions provided that sterile neutrinos with $\Delta m^2\gtrsim 1$ eV$^2$ exist.Comment: LaTeX, 24 pages + 16 pages of appendices, 1 figure. V2: typos correcte

Hybridising heuristics within an estimation distribution algorithm for examination timetabling

This paper presents a hybrid hyper-heuristic approach based on estimation distribution algorithms. The main motivation is to raise the level of generality for search methodologies. The objective of the hyper-heuristic is to produce solutions of acceptable quality for a number of optimisation problems. In this work, we demonstrate the generality through experimental results for different variants of exam timetabling problems. The hyper-heuristic represents an automated constructive method that searches for heuristic choices from a given set of low-level heuristics based only on non-domain-specific knowledge. The high-level search methodology is based on a simple estimation distribution algorithm. It is capable of guiding the search to select appropriate heuristics in different problem solving situations. The probability distribution of low-level heuristics at different stages of solution construction can be used to measure their effectiveness and possibly help to facilitate more intelligent hyper-heuristic search methods