Interpretation of porosity and LWD resistivity from the Nankai accretionary wedge in light of clay physicochemical properties: Evidence for erosion and local overpressuring

International audienceIn this study, we used porosity to assess the compaction state of the Nankai accretionary wedge sediments and any implications for stress and pore pressure. However, hydrous minerals affect porosity measurements, and accounting for them is essential toward defining the interstitial porosity truly representative of the compaction state. The water content of sediments was measured in core samples and estimated from logging data using a resistivity model for shale. We used the cation exchange capacity to correct the porosity data for the amount of water bound to clay minerals and to correct the porosity estimates for the surface conductivity of hydrous minerals. The results indicate that several apparent porosity anomalies are significantly reduced by this correction, implying that they are in part artifacts from hydrous minerals. The correction also improves the fit of porosity estimated from logging-while-drilling (LWD) resistivity data to porosity measured on cores. Low overall porosities at the toe of the accretionary wedge and in the splay fault area are best explained by erosion, and we estimated the quantity of sediments eroded within the splay fault area by comparing porosity-effective stress relationships of the sediments to a reference curve. Additionally, a comparison of LWD data with core data (resistivity and P wave velocity) obtained at Site C0001 landward of the mega-splay fault area, suggested a contribution from the fracture porosity to in situ properties on the formation

15th Annual Environmental Law Institute

Materials from the 15th Annual Environmental Law Institute held by UK/CLE in March 1999

Gene Expression Signature Analysis Identifies Vorinostat as a Candidate Therapy for Gastric Cancer

Gastric cancer continues to be one of the deadliest cancers in the world and therefore identification of new drugs targeting this type of cancer is thus of significant importance. The purpose of this study was to identify and validate a therapeutic agent which might improve the outcomes for gastric cancer patients in the future. manifested a reversed pattern.We showed that analysis of gene expression signature may represent an emerging approach to discover therapeutic agents for gastric cancer, such as vorinostat. The observation of altered gene expression after vorinostat treatment may provide the clue to identify the molecular mechanism of vorinostat and those patients likely to benefit from vorinostat treatment