1,191 research outputs found
Analysis of one- and two-particle spectra at RHIC based on a hydrodynamical model
We calculate the one-particle hadronic spectra and correlation functions of
pions based on a hydrodynamical model. Parameters in the model are so chosen
that the one-particle spectra reproduce experimental results of
GeV Au+Au collisions at RHIC. Based on the numerical solution,
we discuss the space-time evolution of the fluid. Two-pion correlation
functions are also discussed. Our numerical solution suggests the formation of
the quark-gluon plasma with large volume and low net baryon density.Comment: LaTeX, 4pages, 4 figures. To appear in the proceedings of Fourth
International Conference on Physics and Astrophysics of Quark-Gluon Plasma
(ICPAQGP-2001), Nov 26-30, 2001, Jaipur, Indi
Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation
Epithelial cells develop morphologically characteristic apical domains that are bordered by tight junctions, the apical–lateral border. Cdc42 and its effector complex Par6–atypical protein kinase c (aPKC) regulate multiple steps during epithelial differentiation, but the mechanisms that mediate process-specific activation of Cdc42 to drive apical morphogenesis and activate the transition from junction formation to apical differentiation are poorly understood. Using a small interfering RNA screen, we identify Dbl3 as a guanine nucleotide exchange factor that is recruited by ezrin to the apical membrane, that is enriched at a marginal zone apical to tight junctions, and that drives spatially restricted Cdc42 activation, promoting apical differentiation. Dbl3 depletion did not affect junction formation but did affect epithelial morphogenesis and brush border formation. Conversely, expression of active Dbl3 drove process-specific activation of the Par6–aPKC pathway, stimulating the transition from junction formation to apical differentiation and domain expansion, as well as the positioning of tight junctions. Thus, Dbl3 drives Cdc42 signaling at the apical margin to regulate morphogenesis, apical–lateral border positioning, and apical differentiation
The VLTI/MIDI view on the inner mass loss of evolved stars from the Herschel MESS sample
The mass-loss process from evolved stars is a key ingredient for our
understanding of many fields of astrophysics, including stellar evolution and
the chemical enrichment of the interstellar medium via stellar yields. One the
main unsolved questions is the geometry of the mass-loss process. Taking
advantage of the results from the Herschel Mass loss of Evolved StarS (MESS)
programme, we initiated a coordinated effort to characterise the geometry of
mass loss from evolved red giants at various spatial scales. For this purpose
we used the MID-infrared interferometric Instrument (MIDI) to resolve the inner
envelope of 14 asymptotic giant branch stars (AGBs) in the MESS sample. In this
contribution we present an overview of the interferometric data collected
within the frame of our Large Programme, and we also add archive data for
completeness. We studied the geometry of the inner atmosphere by comparing the
observations with predictions from different geometric models. Asymmetries are
detected for five O-rich and S-type, suggesting that asymmetries in the N band
are more common among stars with such chemistry. We speculate that this fact is
related to the characteristics of the dust grains. Except for one star, no
interferometric variability is detected, i.e. the changes in size of the shells
of non-mira stars correspond to changes of the visibility of less than 10%. The
observed spectral variability confirms previous findings from the literature.
The detection of dust in our sample follows the location of the AGBs in the
IRAS colour-colour diagram: more dust is detected around oxygen-rich stars in
region II and in the carbon stars in region VII. The SiC dust feature does not
appear in the visibility spectrum of UAnt and SSct, which are two carbon stars
with detached shells. This finding has implications for the theory of SiC dust
formation.Comment: 43 pages, 31 figures; accepted for publication in Astronomy &
Astrophysics. Abstract shortened for compilation reasons. Metadata correcte
Some Applications of Thermal Field Theory to Quark-Gluon Plasma
The lecture provides a brief introduction of thermal field theory within
imaginary time formalism, the Hard Thermal Loop perturbation theory and some of
its application to the physics of the quark-gluon plasma, possibly created in
relativistic heavy ion collisions.Comment: 17 pages, 12 figures : Lectures given in "Workshop on Hadron Physics"
during March 7-17, 2005, Puri, Indi
ABCC1: a gateway for pharmacological compounds to the ischaemic brain
By preventing access of drugs to the CNS, the blood-brain barrier hampers developments in brain pharmacotherapy. Strong efforts are currently being made to identify drugs that accumulate more efficaciously in ischaemic brain tissue. We identified an ATP-binding cassette (ABC) transporter, ABCC1, which is expressed on the abluminal surface of the brain capillary endothelium and mildly downregulated in response to focal cerebral ischaemia, induced by intraluminal middle cerebral artery occlusion. In biodistribution studies we show that ABCC1 promotes the accumulation of known neuroprotective and neurotoxic compounds in the ischaemic and non-ischaemic brain, ABCC1 deactivation reducing tissue concentrations by up to two orders of magnitude. As such, ABCC1's expression and functionality in the brain differs from the liver, spleen and testis, where ABCC1 is strongly expressed on parenchymal cells, resulting -- in case of liver and testis -- in directed transport from the tissue into the blood. After focal cerebral ischaemia, ABCC1 deactivation abolished the efficacy of both neuroprotective and neurotoxic compounds. Our data indicate that ABCC1 acts as gateway for pharmacological compounds to the stroke brain. We suggest that the tailoring of compounds binding to abluminal but not luminal ABC transporters may facilitate stroke pharmacotherap
Quench Induced Vortices in the Symmetry Broken Phase of Liquid He
Motivated by the study of cosmological phase transitions, our understanding
of the formation of topological defects during spontaneous symmetry-breaking
and the associated non-equilibrium field theory has recently changed.
Experiments have been performed in superfluid He to test the new ideas
involved. In particular, it has been observed that a vortex density is seen
immediately after pressure quenches from just below the transition.
We discuss possible interpretations of these vortices, conclude they are
consistent with our ideas of vortex formation and propose a modification of the
original experiments.Comment: 29 pages, RevTeX with one EPS figur
Grown-up stars physics with MATISSE
MATISSE represents a great opportunity to image the environment around
massive and evolved stars. This will allow one to put constraints on the
circumstellar structure, on the mass ejection of dust and its reorganization ,
and on the dust-nature and formation processes. MATISSE measurements will often
be pivotal for the understanding of large multiwavelength datasets on the same
targets collected through many high-angular resolution facilities at ESO like
sub-millimeter interferometry (ALMA), near-infrared adaptive optics (NACO,
SPHERE), interferometry (PIONIER, GRAVITY), spectroscopy (CRIRES), and
mid-infrared imaging (VISIR). Among main sequence and evolved stars, several
cases of interest have been identified that we describe in this paper.Comment: SPIE, Jun 2016, Edimbourgh, Franc
Whole-exome Sequencing and an iPSC-Derived Cardiomyocyte Model Provides a Powerful Platform for Gene Discovery in Left Ventricular Hypertrophy
Rationale: Left ventricular hypertrophy (LVH) is a heritable predictor of cardiovascular disease, particularly in blacks. Objective: Determine the feasibility of combining evidence from two distinct but complementary experimental approaches to identify novel genetic predictors of increased LV mass. Methods: Whole-exome sequencing (WES) was conducted in seven African-American sibling trios ascertained on high average familial LV mass indexed to height (LVMHT) using Illumina HiSeq technology. Identified missense or nonsense (MS/NS) mutations were examined for association with LVMHT using linear mixed models adjusted for age, sex, body weight, and familial relationship. To functionally assess WES findings, human induced pluripotent stem cell-derived cardiomyocytes (induced pluripotent stem cell-CM) were stimulated to induce hypertrophy; mRNA sequencing (RNA-seq) was used to determine gene expression differences associated with hypertrophy onset. Statistically significant findings under both experimental approaches identified LVH candidate genes. Candidate genes were further prioritized by seven supportive criteria that included additional association tests (two criteria), regional linkage evidence in the larger HyperGEN cohort (one criterion), and publically available gene and variant based annotations (four criteria). Results: WES reads covered 91% of the target capture region (of size 37.2 MB) with an average coverage of 65×. WES identified 31,426 MS/NS mutations among the 21 individuals. A total of 295 MS/NS variants in 265 genes were associated with LVMHT with q-value <0.25. Of the 265 WES genes, 44 were differentially expressed (P < 0.05) in hypertrophied cells. Among the 44 candidate genes identified, 5, including HLA-B, HTT, MTSS1, SLC5A12, and THBS1, met 3 of 7 supporting criteria. THBS1 encodes an adhesive glycoprotein that promotes matrix preservation in pressure-overload LVH. THBS1 gene expression was 34% higher in hypertrophied cells (P = 0.0003) and a predicted conserved and damaging NS variant in exon 13 (A2099G) was significantly associated with LVHMT (P = 4 × 10−6). Conclusion: Combining evidence from cutting-edge genetic and cellular experiments can enable identification of novel LVH risk loci
Antimatter and Matter Production in Heavy Ion Collisions at CERN (The NEWMASS Experiment NA52)
Besides the dedicated search for strangelets NA52 measures light
(anti)particle and (anti)nuclei production over a wide range of rapidity.
Compared to previous runs the statistics has been increased in the 1998 run by
more than one order of magnitude for negatively charged objects at different
spectrometer rigidities. Together with previous data taking at a rigidity of
-20 GeV/c we obtained 10^6 antiprotons 10^3 antideuterons and two antihelium3
without centrality requirements. We measured nuclei and antinuclei
(p,d,antiprotons, antideuterons) near midrapidity covering an impact parameter
range of b=2-12 fm. Our results strongly indicate that nuclei and antinuclei
are mainly produced via the coalescence mechanism. However the centrality
dependence of the antibaryon to baryon ratios show that antibaryons are
diminished due to annihilation and breakup reactions in the hadron dense
environment. The volume of the particle source extracted from coalescence
models agrees with results from pion interferometry for an expanding source.
The chemical and thermal freeze-out of nuclei and antinuclei appear to coincide
with each other and with the thermal freeze-out of hadrons.Comment: 12 pages, 8 figures, to appear in the proceedings of the conference
on 'Fundamental Issues in Elementary Matter' Bad Honnef, Germany, Sept.
25-29, 200
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