699 research outputs found
In-vivo data-driven parcellation of Heschl’s gyrus using structural connectivity
The human auditory cortex around Heschl’s gyrus (HG) exhibits diverging patterns across individuals owing to the heterogeneity of its substructures. In this study, we investigated the subregions of the human auditory cortex using data-driven machine-learning techniques at the individual level and assessed their structural and functional profiles. We studied an openly accessible large dataset of the Human Connectome Project and identified the subregions of the HG in humans using data-driven clustering techniques with individually calculated imaging features of cortical folding and structural connectivity information obtained via diffusion magnetic resonance imaging tractography. We characterized the structural and functional profiles of each HG subregion according to the cortical morphology, microstructure, and functional connectivity at rest. We found three subregions. The first subregion (HG1) occupied the central portion of HG, the second subregion (HG2) occupied the medial-posterior-superior part of HG, and the third subregion (HG3) occupied the lateral-anterior-inferior part of HG. The HG3 exhibited strong structural and functional connectivity to the association and paralimbic areas, and the HG1 exhibited a higher myelin density and larger cortical thickness than other subregions. A functional gradient analysis revealed a gradual axis expanding from the HG2 to the HG3. Our findings clarify the individually varying structural and functional organization of human HG subregions and provide insights into the substructures of the human auditory cortex
Hybrid bright-field and hologram imaging of cell dynamics
Volumetric observation is essential for understanding the details of complex biological phenomena.
In this study, a bright-field microscope, which provides information on a specific 2D plane, and a
holographic microscope, which provides information spread over 3D volumes, are integrated to acquire
two complementary images simultaneously. The developed system was successfully applied to capture
distinct T-cell adhesion dynamics on inflamed endothelial layers, including capture, rolling, crawling,
transendothelial migration, and subendothelial migration.113Ysciescopu
The orbitofrontal cortex functionally links obesity and white matter hyperintensities
© 2020, The Author(s).Many studies have linked dysfunction in cognitive control-related brain regions with obesity and the burden of white matter hyperintensities (WMHs). This study aimed to explore how functional connectivity differences in the brain are associated with WMH burden and degree of obesity using resting-state functional magnetic resonance imaging (fMRI) in 182 participants. Functional connectivity measures were compared among four different groups: (1) low WMH burden, non-obese; (2) low WMH burden, obese; (3) high WMH burden, non-obese; and (4) high WMH burden, obese. At a large-scale network-level, no networks showed significant interaction effects, but the frontoparietal network showed a main effect of degree of obesity. At a finer node level, the orbitofrontal cortex showed interaction effects between periventricular WMH burden and degree of obesity. Higher functional connectivity was observed when the periventricular WMH burden and degree of obesity were both high. These results indicate that the functional connectivity of the orbitofrontal cortex is affected by the mutual interaction between the periventricular WMHs and degree of obesity. Our results suggest that this region links obesity with WMHs in terms of functional connectivity11sciescopu
Convolutional State Space Models for Long-Range Spatiotemporal Modeling
Effectively modeling long spatiotemporal sequences is challenging due to the
need to model complex spatial correlations and long-range temporal dependencies
simultaneously. ConvLSTMs attempt to address this by updating tensor-valued
states with recurrent neural networks, but their sequential computation makes
them slow to train. In contrast, Transformers can process an entire
spatiotemporal sequence, compressed into tokens, in parallel. However, the cost
of attention scales quadratically in length, limiting their scalability to
longer sequences. Here, we address the challenges of prior methods and
introduce convolutional state space models (ConvSSM) that combine the tensor
modeling ideas of ConvLSTM with the long sequence modeling approaches of state
space methods such as S4 and S5. First, we demonstrate how parallel scans can
be applied to convolutional recurrences to achieve subquadratic parallelization
and fast autoregressive generation. We then establish an equivalence between
the dynamics of ConvSSMs and SSMs, which motivates parameterization and
initialization strategies for modeling long-range dependencies. The result is
ConvS5, an efficient ConvSSM variant for long-range spatiotemporal modeling.
ConvS5 significantly outperforms Transformers and ConvLSTM on a long horizon
Moving-MNIST experiment while training 3X faster than ConvLSTM and generating
samples 400X faster than Transformers. In addition, ConvS5 matches or exceeds
the performance of state-of-the-art methods on challenging DMLab, Minecraft and
Habitat prediction benchmarks and enables new directions for modeling long
spatiotemporal sequences
The Non-Destructive and Nano-Microstructural Characterization of Thermal-Barrier Coatings
The durability of thermal barrier coatings (TBCs) plays an important role in the service reliability and maintainability of hot-section components in advanced turbine engines for aerospace and utility applications. Photostimulated luminescence spectroscopy (PSLS) and electrochemical impedance spectroscopy (EIS) are being concurrently developed as complimentary nondestructive evaluation (NDE) techniques for quality control and liferemain assessment of TBCs. This paper discusses recent achievements in understanding the residual stress, phase constituents, and electrochemical resistance (or capacitance) of TBC constituents—with an emphasis on the thermally grown oxide. Results from NDE by PSLS and EIS are correlated to the nano- and microstructural development of TBCs
The Non-Destructive and Nano-Microstructural Characterization of Thermal-Barrier Coatings
The durability of thermal barrier coatings (TBCs) plays an important role in the service reliability and maintainability of hot-section components in advanced turbine engines for aerospace and utility applications. Photostimulated luminescence spectroscopy (PSLS) and electrochemical impedance spectroscopy (EIS) are being concurrently developed as complimentary nondestructive evaluation (NDE) techniques for quality control and liferemain assessment of TBCs. This paper discusses recent achievements in understanding the residual stress, phase constituents, and electrochemical resistance (or capacitance) of TBC constituents—with an emphasis on the thermally grown oxide. Results from NDE by PSLS and EIS are correlated to the nano- and microstructural development of TBCs
Piezoacoustics for precision control of electrons floating on helium
Piezoelectric surface acoustic waves (SAWs) are powerful for investigating
and controlling elementary and collective excitations in condensed matter. In
semiconductor two-dimensional electron systems SAWs have been used to reveal
the spatial and temporal structure of electronic states, produce quantized
charge pumping, and transfer quantum information. In contrast to
semiconductors, electrons trapped above the surface of superfluid helium form
an ultra-high mobility, two-dimensional electron system home to
strongly-interacting Coulomb liquid and solid states, which exhibit non-trivial
spatial structure and temporal dynamics prime for SAW-based experiments. Here
we report on the coupling of electrons on helium to an evanescent piezoelectric
SAW. We demonstrate precision acoustoelectric transport of as little as ~0.01%
of the electrons, opening the door to future quantized charge pumping
experiments. We also show SAWs are a route to investigating the high-frequency
dynamical response, and relaxational processes, of collective excitations of
the electronic liquid and solid phases of electrons on helium.Comment: Main manuscript: 15 pages, 3 figures; Supplemental Information: 11
pages, 3 figures, 1 tabl
Effect of diabetic duration on hemorheological properties and platelet aggregation in streptozotocin-induced diabetic rats
Diabetes mellitus with abnormal glucose concentration is associated with changes in hemorheological properties, endothelial function, and platelets hyperactivity. Disturbances may significantly be responsible for diabetes-related vascular complications. In this study, hemorheological and hemodynamic properties were measured according to diabetic duration after streptozotocin treatment in rats. For ex vivo measurements, an extracorporeal model was adopted. Flow rate and blood viscosity were measured using a microfluidic device. Erythrocyte aggregation and morphological parameters of erythrocytes were measured by modified erythrocyte sedimentation rate and the phase-contrast holography under in vitro conditions. The platelet aggregation and mean pressure in the femoral artery were estimated under ex vivo conditions. Hemorheological properties including blood viscosity, erythrocyte aggregation and shape parameters for the control group are significantly different with those for diabetic groups. The changes with respect to diabetic duration were relatively unnoticeable. However, the platelet aggregation is strongly dependent on the diabetic duration. Based on these results, hyperglycemia exposure may induce hemorheological variations in early stages of diabetes mellitus. High platelet aggregation may become more pronounced according to the diabetic duration caused by variations in hemorheological properties resulting in endothelial dysfunction. This study would be helpful in understanding the effects of diabetic duration on biophysical properties.open11149sciescopu
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