Observations on the Helminths of Harbour Porpoises (Phocoena Phocoena) and Common Guillemots (Uria Aalge) from the Belgian and German Coasts

Between February 1990 and July 1991, 18 harbour porpoises (Phocoena phocoena) and 248 common guillemots (Uria aalge), found dead along the Belgian and German coasts, were examined for their burden of helminths. A total of three species were found in the guillemots (one cestode, one nematode and one pentastomid), and six species in the porpoises (one trematode, one cestode and four nematodes). Among the guillemots the burden of helminths was not statistically different between juvenile and adult birds. The deaths of the birds were apparently not related to the parasite infections. In contrast, the adult porpoises were more heavily parasitised than the juveniles, except for one young porpoise stranded on the Belgian coast. In the porpoises, four species of parasites had a pathological effect and Torynurus convolutus was responsible for the death of one animal from the Belgian coast and three from the German coast

Occupational exposure to N-nitrosamines and pesticides and risk of pancreatic cancer

Objectives Animal evidence shows that N-nitrosamines and similar xenobiotic compounds are pancreatic carcinogens. We aimed to determine whether occupational exposure to N-nitrosamines or to pesticides increases risk of pancreatic cancer development. Methods Participants (504 cases, 643 controls) in a population-based case-control study (The Queensland Pancreatic Cancer Study) provided data on demographic, medical and lifestyle factors and lifetime job histories. Specific questions were asked regarding work in rubber and leather industries, metalworking jobs and occupational or direct use of pesticides on animals or crops. An occupational hygienist reviewed this information (blind to case status) to assess likelihood of exposure to N-nitrosamines and pesticides, and estimated level and frequency of such exposures. Results No associations were found for risk of pancreatic cancer and occupational exposure to N-nitrosamines (OR=0.85, 95% CI 0.51 to 1.42) and no associations were seen with level or frequency of exposure. No associations were observed for ever exposure to pesticides in general (OR=0.90, 95% CI 0.61 to 1.33) or to any of the pesticide subgroups. Stratification by history of cigarette smoking did not change these results. Conclusions This comprehensive analysis of a large case-control study does not support an association between occupational exposure to N-nitrosamines or pesticide use and risk of pancreatic cancer

The effects of acute and elective cardiac surgery on the anxiety traits of patients with Marfan syndrome

BACKGROUND: Marfan syndrome is a genetic disease, presenting with dysfunction of connective tissues leading to lesions in the cardiovascular and skeletal muscle system. Within these symptoms, the most typical is weakness of the connective tissue in the aorta, manifesting as aortic dilatation (aneurysm). This could, in turn, become annuloaortic ectasia, or life-threatening dissection. As a result, life-saving and preventative cardiac surgical interventions are frequent among Marfan syndrome patients. Aortic aneurysm could turn into annuloaortic ectasia or life-threatening dissection, thus life-saving and preventive cardiac surgical interventions are frequent among patients with Marfan syndrome. We hypothesized that patients with Marfan syndrome have different level of anxiety, depression and satisfaction with life compared to that of the non-clinical patient population. METHODS: Patients diagnosed with Marfan syndrome were divided into 3 groups: those scheduled for prophylactic surgery, those needing acute surgery, and those without need for surgery (n = 9, 19, 17, respectively). To examine the psychological features of the patients, Spielberger's anxiety (STAI) test, Beck's Depression questionnaire (BDI), the Berne Questionnaire of Subjective Well-being, and the Satisfaction with Life scale were applied. RESULTS: A significant difference was found in trait anxiety between healthy individuals and patients with Marfan syndrome after acute life-saving surgery (p 0.1). Finally, a significant, medium size effect was found between patient groups on the Joy in Living scale (F (2.39) = 3.51, p = 0.040, eta2 = 0.15). CONCLUSIONS: Involving psychiatric and mental-health care, in addition to existing surgical treatment interventions, is essential for more successful recovery of patients with Marfan syndrome

Solving order constraints in logarithmic space.

We combine methods of order theory, finite model theory, and universal algebra to study, within the constraint satisfaction framework, the complexity of some well-known combinatorial problems connected with a finite poset. We identify some conditions on a poset which guarantee solvability of the problems in (deterministic, symmetric, or non-deterministic) logarithmic space. On the example of order constraints we study how a certain algebraic invariance property is related to solvability of a constraint satisfaction problem in non-deterministic logarithmic space

Effects of ganaxolone on non-seizure outcomes in CDKL5 Deficiency Disorder: Double-blind placebo-controlled randomized trial.

CDKL5 deficiency disorder (CDD) is a rare developmental and epileptic encephalopathy. Ganaxolone, a neuroactive steroid, reduces the frequency of major motor seizures in children with CDD. This analysis explored the effect of ganaxolone on non-seizure outcomes. Children (2-19 years) with genetically confirmed CDD and ≥ 16 major motor seizures per month were enrolled in a double-blind randomized placebo-controlled trial. Ganaxolone or placebo was administered three times daily for 17 weeks. Behaviour was measured with the Anxiety, Depression and Mood Scale (ADAMS), daytime sleepiness with the Child Health Sleep Questionnaire, and quality of life with the Quality of Life Inventory-Disability (QI-Disability) scale. Scores were compared using ANOVA, adjusted for age, sex, number of anti-seizure mediations, baseline 28-day major motor seizure frequency, baseline developmental skills, and behaviour, sleep or quality of life scores. 101 children with CDD (39 clinical sites, 8 countries) were randomized. Median (IQR) age was 6 (3-10) years, 79.2 % were female, and 50 received ganaxolone. After 17 weeks of treatment, Manic/Hyperactive scores (mean difference 1.27, 95%CI -2.38,-0.16) and Compulsive Behaviour scores (mean difference 0.58, 95%CI -1.14,-0.01) were lower (improved) in the ganaxolone group compared with the placebo group. Daytime sleepiness scores were similar between groups. The total change in QOL score for children in the ganaxolone group was 2.6 points (95%CI -1.74,7.02) higher (improved) than in the placebo group but without statistical significance. Along with better seizure control, children who received ganaxolone had improved behavioural scores in select domains compared to placebo

Selection of multiple donor gauges via Graphical Lasso for estimation of daily streamflow time series

A fundamental challenge in estimations of daily streamflow time series at sites with incomplete records is how to effectively and efficiently select reference or donor gauges from an existing gauge network to infer the missing data. While research on estimating missing streamflow time series is not new, the existing approaches either use a single reference streamflow gauge or employ a set of "ad-hoc" reference gauges, leaving a systematic selection of reference gauges as a long-standing open question. In this work, a novel method is introduced that facilitates systematical selection of multiple reference gauges from any given streamflow network. The idea is to mathematically characterize the network-wise correlation structure of a streamflow network via graphical Markov modeling, and further transforms a dense network into a sparsely connected one. The resulted underlying sparse graph from the graphical model encodes conditional independence conditions among all reference gauges from the streamflow network, allowing determination of an optimum subset of the donor gauges. The sparsity is discovered by using the Graphical Lasso algorithm with an L1-norm regularization parameter and a thresholding parameter. These two parameters are determined by a multi-objective optimization process. Furthermore, the graphical modeling approach is employed to solve another open problem in gauge removal planning decision (e.g., due to operation budget constraints): which gauges to remove would statistically guarantee the least loss of information by estimations from the remaining gauges? Our graphical model-based method is demonstrated with daily streamflow data from a network of 34 gauges over the Ohio River basin.Comment: arXiv admin note: substantial text overlap with arXiv:2004.0137

TANAMI: Tracking Active Galactic Nuclei with Austral Milliarcsecond Interferometry. III. First-epoch S band images

With the emergence of very high energy astronomy (VHE; E>100 GeV), new open questions were presented to astronomers studying the multi-wavelength emission from blazars. Answers to these open questions, such as the Doppler crisis, and finding the location of the high-energy activity have eluded us thus far. Recently, quasi-simultaneous multi-wavelength monitoring programs have shown considerable success in investigating blazar activity. After the launch of the Fermi Gamma-ray Space Telescope in 2008, such quasi-simultaneous observations across the electromagnetic spectrum became possible. In addition, with very long baseline interferometry (VLBI) observations we can resolve the central parsec region of active galactic nuclei (AGN) and compare morphological changes to the gamma-ray activity to study high-energy emitting blazars. To achieve our goals, we need sensitive, long-term VLBI monitoring of a complete sample of VHE detected AGN. We performed VLBI observations of TeV-detected AGN and high likelihood neutrino associations as of December of 2021 with the Long Baseline Array (LBA) and other southern hemisphere radio telescopes at 2.3 GHz. In this paper we present first light TANAMI S-band images, focusing on the TeV-detected sub-sample of the full TANAMI sample. Apart from these very high energy-detected sources, we also show images of the two flux density calibrators and two additional sources included in the observations. We study the redshift, 0.1-100 GeV photon flux and S-band core brightness temperature distributions of the TeV-detected objects, and find that flat spectrum radio quasars and low synchrotron peaked sources on average show higher brightness temperatures than high-synchrotron-peaked BL Lacs. Sources with bright GeV gamma-ray emission also show higher brightness temperature values than gamma-low sources

Auditory hallucinations and migraine of possible brainstem origin

10.1007/s10194-011-0355-zJournal of Headache and Pain125573-57

Calreticulin mutations affect its chaperone function and perturb the glycoproteome

Calreticulin (CALR) is an endoplasmic reticulum (ER)-retained chaperone that assists glycoproteins in obtaining their structure. CALR mutations occur in patients with myeloproliferative neoplasms (MPNs), and the ER retention of CALR mutants (CALR MUT) is reduced due to a lacking KDEL sequence. Here, we investigate the impact of CALR mutations on protein structure and protein levels in MPNs by subjecting primary patient samples and CALR-mutated cell lines to limited proteolysis-coupled mass spectrometry (LiP-MS). Especially glycoproteins are differentially expressed and undergo profound structural alterations in granulocytes and cell lines with homozygous, but not with heterozygous, CALR mutations. Furthermore, homozygous CALR mutations and loss of CALR equally perturb glycoprotein integrity, suggesting that loss-of-function attributes of mutated CALR chaperones (CALR MUT) lead to glycoprotein maturation defects. Finally, by investigating the misfolding of the CALR glycoprotein client myeloperoxidase (MPO), we provide molecular proof of protein misfolding in the presence of homozygous CALR mutations. Keywords: CP: Cancer; CP: Molecular biology; calreticulin; chaperone; glycoprotein; limited proteolysis-coupled mass spectrometry; myeloperoxidase; myeloproliferative neoplasm; protein folding; proteome