Stochastic optimization of a cold atom experiment using a genetic algorithm

We employ an evolutionary algorithm to automatically optimize different stages of a cold atom experiment without human intervention. This approach closes the loop between computer based experimental control systems and automatic real time analysis and can be applied to a wide range of experimental situations. The genetic algorithm quickly and reliably converges to the most performing parameter set independent of the starting population. Especially in many-dimensional or connected parameter spaces the automatic optimization outperforms a manual search.Comment: 4 pages, 3 figure

Two-point phase correlations of a one-dimensional bosonic Josephson junction

We realize a one-dimensional Josephson junction using quantum degenerate Bose gases in a tunable double well potential on an atom chip. Matter wave interferometry gives direct access to the relative phase field, which reflects the interplay of thermally driven fluctuations and phase locking due to tunneling. The thermal equilibrium state is characterized by probing the full statistical distribution function of the two-point phase correlation. Comparison to a stochastic model allows to measure the coupling strength and temperature and hence a full characterization of the system

Электрооборудование агрегата перекачки топлива

Объектом исследования является частотно-регулируемый электропривод переменного тока электронасосного агрегата. Целью выпускной квалификационной работы является проектирование электрооборудования и асинхронного электропривода насосного агрегата. В результате исследования была разработана системы регулирования насосного агрегата и защит. Выпускная квалификационная работа выполнена с помощью программ MATLAB, Mathcad 14, в текстовом редакторе MS Word и представлена на компакт - диске (в конверте на обороте обложки).Probe plant is the frequent-regulated electric drive of alternate current of the electropump aggregate. The purpose of final qualification operation is projection of electric equipment and the asynchronous electric drive of the pumping aggregate. As a result of probe has been developed regulating systems of the pumping aggregate and guards. Final qualification operation is executed by means of programs MATLAB, Mathcad 14, in text editor MS Word and is presented on a compact set - a disk (in an envelope on the back of a cover)

Gastrointestinal Tract As Entry Route for Hantavirus Infection

Background: Hantaviruses are zoonotic agents that cause hemorrhagic fevers and are thought to be transmitted to humans by exposure to aerosolized excreta of infected rodents. Puumala virus (PUUV) is the predominant endemic hantavirus in Europe. A large proportion of PUUV-infected patients suffer from gastrointestinal symptoms of unclear origin. In this study we demonstrate that PUUV infection can occur via the alimentary tract. Methods: We investigated susceptibility of the human small intestinal epithelium for PUUV infection and analyzed the resistance of virions to gastric juice. As model for intestinal virus translocation we performed infection experiments with human intestinal Caco-2 monolayers. In animal experiments we infected Syrian hamsters with PUUV via the intragastric route and tested seroconversion and protective immunity against subsequent Andes virus challenge. Results: PUUV retained infectivity in gastric juice at pH >3. The virus invaded Caco-2 monolayers in association with endosomal antigen EEA1, followed by virus replication and loss of epithelial barrier function with basolateral virus occurrence. Cellular disturbance and depletion of the tight junction protein ZO-1 appeared after prolonged infection, leading to paracellular leakage (leak flux diarrhea). Moreover, animal experiments led to dose-dependent seroconversion and protection against lethal Andes virus challenge. Conclusions: We provide evidence that hantavirus can infect the organism via the alimentary tract and suggest a novel aspect of hantavirus infection and pathogenesis. Significance: Hantaviruses are zoonotic pathogens causing severe hemorrhagic fevers worldwide. They are transmitted to humans by small mammals. To date, these viruses were thought to infect exclusively through the airborne route by inhalation of aerosols from infectious animal droppings or by rodent bites. In our work we could show that the alimentary tract is an alternative path of infection for hantaviruses, meaning a new association of virus and disease. These findings have impact on current textbook knowledge and bring many implications for hantavirus epidemiology and outbreak prevention measures

The Problem Of Social Well-Being In The Period Of Perestroika

A qualitatively new stage in the development of the scientific-educational complex in Tomsk, as well as in the whole country, came with the speech of the General Secretary of the CPSU Central Committee M.S. Gorbachev at the April plenum of the party, which marked the beginning of the period of "perestroika" in 1985. The era of perestroika was marked by a number of contradictory tendencies in the science and educational institutions of the country in general and SPhTI in particular. "Perestroika" went under the slogans of "glasnost", "new political thinking". On the one hand, the processes of democratization that began in the country served as a powerful impetus for the academic community to find new ways to solve the urgent economic, environmental and social problems. On the other hand, at that time the alarming tendencies of the obsolescence of the material and technical base for research and academic institutions, ineffectiveness or the lack of active implementation of applied developments began to make themselves felt. Particular attention is paid to identify and analyze the dynamics of the transformation of organizational forms of research development in the Tomsk scientific-educational complex; analyze the specifics of state budget financing and contractual activity as reasons for the reduction of the staff of physicists and analyze the specifics of the material and living conditions of the academic community of Tomsk in the period of Perestroika. For all who are interested in the history of science, the history of Siberia and Russia