Smart Retail in Smart Cities: Best Practice Analysis of Local Online Platforms

Against the background of urban transformation processes aggravated by e-commerce, this paper discusses chances and challenges of local online platforms. Three hypotheses are introduced. Firstly, the rapid emergence of numerous local online platforms in various European countries is linked to the urban heritage of the European City. Secondly, the success of these platforms depends on the integration of diverse services. Thirdly it is argued, that platforms need to adapt to future topics of smart retail which is why a more holistic approach is appropriate. A best practice analysis is conducted, which gives an insight into the variety and complexity of local online platforms

Patterns of HER-2/neu Amplification and Overexpression in Primary and Metastatic Breast Cancer

Background: Only 25% of patients with HER-2/neu-positive metastatic breast tumors respond favorably to trastuzamab (Herceptin) treatment. We hypothesized that a high failure rate of patients on trastuzamab could result if some of the metastases were HER-2 negative and these metastases ultimately determine the course of the disease. Methods: We used tissue microarrays (TMAs) containing four samples each from 196 lymph node-negative primary tumors, 196 lymph node-positive primary tumors, and three different lymph node metastases from each lymph node-positive tumor to estimate HER-2 gene amplification by fluorescence in situ hybridization (FISH) and Her-2 protein overexpression by immunohistochemistry (IHC). Results: FISH and IHC analyses gave the same result with respect to HER-2 status for 93.7% of the tissues contained in the TMAs. Tissue samples were, therefore, considered to be HER-2 positive if they were positive for either HER-2 DNA amplification or Her-2 protein expression and HER-2 negative if both FISH and IHC gave a negative result. The HER-2 status of lymph node-positive primary tumors was maintained in the majority of their metastases. For HER-2-positive primary tumors, 77% (95% confidence interval [CI] = 59% to 90%) had entirely HER-2-positive metastases, 6.5% (95% CI = 8% to 21%) had entirely HER-2-negative metastases, and 16.3% (95% CI = 5% to 34%) had a mixture of HER-2-positive and HER-2-negative metastases. For HER-2-negative primary tumors, 95% (95% CI = 88% to 98%) had metastases that were entirely negative for HER-2. Conclusions: Our data suggest that differences in HER-2 expression between primary tumors and their lymph node metastases cannot explain the high fraction of nonresponders to trastuzamab therap

Smart Retail in Smart Cities: Best Practice Analysis of Local Online Platforms

Against the background of urban transformation processes aggravated by e-commerce, this paper discusses chances and challenges of local online platforms. Three hypotheses are introduced. Firstly, the rapid emergence of numerous local online platforms in various European countries is linked to the urban heritage of the European City. Secondly, the success of these platforms depends on the integration of diverse services. Thirdly it is argued, that platforms need to adapt to future topics of smart retail which is why a more holistic approach is appropriate. A best practice analysis is conducted, which gives an insight into the variety and complexity of local online platforms

Smart Retail in Smart Cities: Best Practice Analysis of Local Online Platforms

Against the background of urban transformation processes aggravated by e-commerce, this paper discusses chances and challenges of local online platforms. Three hypotheses are introduced. Firstly, the rapid emergence of numerous local online platforms in various European countries is linked to the urban heritage of the European City. Secondly, the success of these platforms depends on the integration of diverse services. Thirdly it is argued, that platforms need to adapt to future topics of smart retail which is why a more holistic approach is appropriate. A best practice analysis is conducted, which gives an insight into the variety and complexity of local online platforms