Modelling Ultra High Pressure Compaction of Powder

The use of high pressure high temperature (HPHT) equipment varies; in mineral physics research the equipment is used for investigation of the earth’s interior and in industry it is used for commercially produced synthetic diamonds and other polycrystalline products. The common denominator for almost all high pressure systems is to use capsules where a powder material encloses the core material. Numerical analysis of the manufacturing processes with working conditions which reaches ultra high pressure (above 10 GPa) requires a constitutive model which can handle the specific behaviours of the powder from a low density to solid state. Calcium carbonate (CaCO3) is a mineral that can be used in high pressure processes and is very common in the earth core. A constitutive model for calcium carbonate applied to high pressure compaction is presented. The plastic response of powder is non-linear and described in a rate-independent cap plasticity model. The cap model has been developed to capture the behaviour of minerals in high pressure applications. The yield function consists of a failure envelope fitted to a strain-hardening cap. Experimental tests with a Bridgman anvil set-up using calcium carbonate powder discs are performed. Numerical analysis using the finite element method is done to virtually reproduce the experiments. Results from the analysis are compared to measured experimental results. The numerical analyses agree reasonably well with the experimental results

Preparation, characterization and catalytic behavior for propanepartial oxidation of Ga-promoted MoVTeO catalysts

[EN] Two sets of Ga-promoted MoVTeO catalysts were synthesized hydrothermally and heat-treated at 600 degrees C in N-2: (i) materials prepared from gels with Mo/V/Te/Ga atomic ratios of 1/0.60/0.17/x (x=0-0.12) (A-series) and (ii) materials prepared from gels with Mo/V/Te/Ga atomic ratios of 1/0.60-x/0.17/x (x=0.15 or 0.25) (B-series). In addition, a Ga-containing MoVTeO catalyst was also prepared from M1-containing MoVTeO material by impregnation with aqueous solution of gallium and heat-treated at 450 degrees C in N-2. Catalysts were characterized by means of powder XRD, TEM, Raman spectroscopy, NH3-TPD and XPS and tested in the partial oxidation of propane. The results showed that the addition of small amount of gallium significantly increase the selectivity to acrylic acid (AA) at low propane conversion. However, at high propane conversion, the selectivity to AA strongly depends on both the catalyst composition and the gallium incorporation method. The higher selectivity to acrylic acid over Ga-containing MoVTeO catalysts has been related to: (i) structural changes in the M1 phase by the incorporation of Ga3+ into the octahedral structural framework and/or (ii) incorporation of Ga3+ species on the catalyst surface thus modifying catalysts acid properties. (C) 2014 Elsevier B.V. All rights reserved.Financial support from DGICYT in Spain (Project CTQ2012-37925-C03-1 and Program Severo Ochoa SEV-2012-0267) is gratefully acknowledged. EGG acknowledges finantial support through spanish project MAT2010-19837-C06-05 and the ICTS-Microscopia Electronica in Madrid for facilities.Hernández Morejudo, S.; Massó Ramírez, A.; García-González, E.; Concepción Heydorn, P.; López Nieto, JM. (2015). Preparation, characterization and catalytic behavior for propanepartial oxidation of Ga-promoted MoVTeO catalysts. Applied Catalysis A: General. 504:51-61. https://doi.org/10.1016/j.apcata.2014.12.039S516150

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical development. In the present study, we demonstrate a role for MTHFD2 in DNA replication and genomic stability in cancer cells, and perform a drug screen to identify potent and selective nanomolar MTHFD2 inhibitors; protein cocrystal structures demonstrated binding to the active site of MTHFD2 and target engagement. MTHFD2 inhibitors reduced replication fork speed and induced replication stress followed by S-phase arrest and apoptosis of acute myeloid leukemia cells in vitro and in vivo, with a therapeutic window spanning four orders of magnitude compared with nontumorigenic cells. Mechanistically, MTHFD2 inhibitors prevented thymidine production leading to misincorporation of uracil into DNA and replication stress. Overall, these results demonstrate a functional link between MTHFD2-dependent cancer metabolism and replication stress that can be exploited therapeutically with this new class of inhibitors

Informe del Taller Regional de Estadísticas Ambientales: "Hacia el desarrollo de un conjunto básico de estadísticas ambientales", Santiago de Chile, 26 al 28 de noviembre de 2003"

The prediction of transient granular material flow is of fundamental industrial importance. The potential of using numerical methods in system design for increasing the operating efficiency of industrial processes involving granular material flow is huge. In the present study, a numerical tool for modelling dense transient granular material flow is presented and validated against experiments. The granular materials are modelled as continuous materials using two different constitutive models. The choice of constitutive models is made with the aim to predict the mechanical behaviour of a granular material during the transition from stationary to flowing and back to stationary state. The particle finite element method (PFEM) is employed as a numerical tool to simulate the transient granular material flow. Use of the PFEM enables a robust treatment of large deformations and free surfaces. The fundamental problem of collapsing rectangular columns of granular material is studied experimentally employing a novel approach for in-plane velocity measurements by digital image correlation. The proposed numerical model is used to simulate the experimentally studied column collapses. The model prediction of the in-plane velocity field during the collapse agrees well with experiments.Validerad;2021;Nivå 2;2021-01-22 (alebob);Finansiär: KIC RawMaterials (17152)</p

Green body behaviour of high velocity pressed metal powder

High velocity compaction (HVC) is a production technique with capacity to significantly improve the mechanical properties of powder metallurgy (PM) parts. Several investigations indicate that high-density components can by obtained using HVC. Other characteristics are low ejection force and uniform density. Investigated here are green body data such as density, tensile strength, radial springback, ejection force and surface flatness. Comparisons are performed with conventional compaction using the same pressing conditions. Cylindrical samples of a pre-alloyed water atomized iron powder are used in this experimental investigation. The different behaviour of HVC-pressed green bodies compared to conventional pressed green bodies are analysed and discussed. The HVC process in this study resulted in a better compressibility curve and lower ejection force compared to conventional quasi static pressing. Vertical scanning interferometry (VSI) measurements show that the HVC process gives flatter sample surfaces.Validerad; 2007; 20070216 (cira)</p