Survey of laying hen husbandry in Switzerland

In Switzerland eggs have not been produced in battery cages since January 1992. During the 10 year period from 1981 farmers replaced their battery cages with deep litter, aviary and grid-floor systems and modified cages. However, the cages used to replace the conventional battery cages and most of the grid- floor systems did not fulfil the requirements of the Swiss Welfare Act and they were not permitted to be advertised or sold thereafter. Sixteen years after the ban on battery cages, the Federal Veterinary Office has undertaken a survey to determine how laying hens are kept in Switzerland and how the alternative systems have fared. The survey was carried out on 96 randomly chosen farms with at least 500 hen places to find out more about the housing conditions, management processes, status and performance of hens. The results show that aviaries are very common in Switzerland (65% of the laying hens) and that the laying performance in these systems is significantly higher than that in grid- floor systems and similar to that in battery cages. Provision of a protected outdoor area is a valuable benefit. To be successful with aviary systems it is necessary for pullets to spend the rearing period under similar housing condition

Real-World Normal Map Capture for Nearly Flat Reflective Surfaces

Although specular objects have gained interest in recent years, virtually no approaches exist for markerless reconstruction of reflective scenes in the wild. In this work, we present a practical approach to capturing normal maps in real-world scenes using video only. We focus on nearly planar surfaces such as windows, facades from glass or metal, or frames, screens and other indoor objects and show how normal maps of these can be obtained without the use of an artificial calibration object. Rather, we track the reflections of real-world straight lines, while moving with a hand-held or vehicle-mounted camera in front of the object. In contrast to error-prone local edge tracking, we obtain the reflections by a robust, global segmentation technique of an ortho-rectified 3D video cube that also naturally allows efficient user interaction. Then, at each point of the reflective surface, the resulting 2D-curve to 3D-line correspondence provides a novel quadratic constraint on the local surface normal. This allows to globally solve for the shape by integrability and smoothness constraints and easily supports the usage of multiple lines. We demonstrate the technique on several objects and facades

Structure-affinity relationships of 2,3,4,5-Tetrahydro-1H-3-benzazepine and 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-amine analogues and the discovery of a radiofluorinated 2,3,4,5-Tetrahydro-1H-3-benzazepine congener for imaging GluN2B subunit-containing N-Methyl-d-aspartate receptors

Aspiring to develop a positron emission tomography (PET) imaging agent for the GluN2B subunits of the N-methyl-d-aspartate receptor (NMDAR), a key therapeutic target for drug development toward several neurological disorders, we synthesized a series of 2,3,4,5-tetrahydro-1H-3-benzazepine and 6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine analogues. After in vitro testing via competition binding assay and autoradiography, [$^{18}$F]PF-NB1 emerged as the best performing tracer with respect to specificity and selectivity over σ1 and σ2 receptors and was thus selected for further in vivo evaluation. Copper-mediated radiofluorination was accomplished in good radiochemical yields and high molar activities. Extensive in vivo characterization was performed in Wistar rats comprising PET imaging, biodistribution, receptor occupancy, and metabolites studies. [$^{18}$F]PF-NB1 binding was selective to GluN2B-rich forebrain regions and was specifically blocked by the GluN2B antagonist, CP-101,606, in a dose-dependent manner with no brain radiometabolites. [$^{18}$F]PF-NB1 is a promising fluorine-18 PET tracer for imaging the GluN2B subunits of the NMDAR and has utility for receptor occupancy studies