Innovaciones docentes mediante competencias en las ciencias jurídicas en el Espacio Europeo de Educación Superior

Este trabajo pretende acercarse al nuevo mundo que se encuentra todo estudiante de Derecho en las Facultades de nuestro país con una innumerable cantidad de innovaciones docentes como consecuencia de la construcción del Espacio Europeo de Educación superior. Más concretamente, tras una vaga explicación de todo lo que ha supuesto la construcción de este Espacio Europeo de Educación superior, hemos querido mostrar cómo, en las Guías Docentes de las asignaturas de nuestro Área de Conocimiento (Derecho Eclesiástico del Estado) en las que ya está implantado el nuevo sistema del crédito europeo en nuestra Universidad (la Pablo de Olavide de Sevilla), hemos especificado el conjunto de Competencias que, a nuestro entender, debe alcanzar el estudiante de Derecho en todo este nuevo contexto educativo del Espacio Europeo de Educación Superior. Nuestra más importante conclusión nos lleva a ser cautos y a encontrarnos ciertamente preocupados por cuanto se espera de nosotros, los docentes, a los que consideramos que se nos ha atribuido una excesiva carga de trabajo y una excesiva responsabilidad en todo este sistema novedoso. No podemos estimar a la ligera que los únicos responsables en el eventual éxito o fracaso académico de los alumnos seamos los docentes de las ciencias jurídicas porque ello nos parecería totalmente equivocado y desproporcionado

A Robust Constrained Reference Governor Approach using Linear Matrix Inequalities

The purpose of this paper is to examine and provide a solution to the output reference tracking problem for uncertain systems subject to input saturation. As well-known, input saturation and modelling errors are very common problems at industry, where control schemes are implemented without accounting for such problems. In many cases, it is sometimes difficult to modify the existing implemented control schemes being necessary to provide them with external supervisory control approaches in order to tackle problems with constraints and modelling errors. In this way, a cascade structure is proposed, combining an inner loop containing any proper controller with an outer loop where a generalized predictive controller (GPC) provides adequate references for the inner loop considering input saturations and uncertainties. Therefore, the contribution of this paper consists in providing a state space representation for the inner loop and using linear matrix inequalities (LMI) to obtain a predictive state-vector feedback in such a way that the input reference for the inner loop is calculated to satisfy robust tracking specifications considering input saturations. Hence, the final proposed solution consists in solving a regulation problem to a fixed reference value subjected to a set of constraints described by several LMI and bilinear matrix inequalities (BMI). The main contribution of the paper is that the proposed solution is a non-linear setpoint tracking approach, that is, it is allowed that the system goes into saturation facing the problem of setpoint tracking instead of regulating to the origin. An illustrative numerical example is presented.Ministerio de Ciencia y Tecnología DPI2004-07444-C04-01/0

Modelling of non-uniform corrosion-induced cover cracking in reinforced concrete

Cover cracking and spalling in concrete due to corrosion of reinforcement bars is one of the major concerns for durability of reinforced concrete structures and has been widely researched during recent years. Most approaches to the problem are based on a uniform corrosion and expansion pressure around the rebar. However, corrosion rust tends to accumulate around the steel circumference that faces the concrete cover. From this outer part of the rebar, the corrosion front gradually advances to the inner, which entails a non-uniform expansive pressure around the rebar. The purpose of the study is to simulate the effect of non-uniform rust distribution around the corroded rebar, taking advantage of an embedded cohesive crack finite element. The objective is to develop more realistic models for the estimation of the service life of reinforced concrete structure

Low molecular weight ϵ-caprolactone-pcoumaric acid copolymers as potential biomaterials for skin regeneration applications

ϵ-caprolactone-p-coumaric acid copolymers at different mole ratios (ϵ-caprolactone:p-coumaric acid 1:0, 10:1, 8:1, 6:1, 4:1, and 2:1) were synthesized by melt-polycondensation and using 4-dodecylbenzene sulfonic acid as catalyst. Chemical analysis by NMR and GPC showed that copolyesters were formed with decreasing molecular weight as p-coumaric acid content was increased. Physical characteristics, such as thermal and mechanical properties, as well as water uptake and water permeability, depended on the mole fraction of pcoumaric acid. The p-coumarate repetitive units increased the antioxidant capacity of the copolymers, showing antibacterial activity against the common pathogen Escherichia coli. In addition, all the synthesized copolyesters, except the one with the highest concentration of the phenolic acid, were cytocompatible and hemocompatible, thus becoming potentially useful for skin regeneration applications

Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea.

Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH₂Cl₂-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 1-3 displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor (TNF) and Interleukin (IL)-6 induced by lipopolysaccharide (LPS) in murine macrophages

New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum Asbestinum

Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract of Briareum asbestinum collected in Bocas del Toro, on the Caribbean side of Panama, led to the isolation of three new eunicellin-type diterpenes: briarellin T (1), asbestinin 27 (2), asbestinin 28 (3) and the previously described asbestinin 17 (4). The structures of the new compounds were determined by extensive NMR analyses and HRMS. Anti-inflammatory activity assays showed a significant reduction of the pro-inflammatory cytokines TNF-α, IL-6, IL-1β and IL-8 as well as a downregulation of COX-2 expression in LPS-stimulated THP-1 macrophages. These findings support the potential use of these marine compounds as therapeutic agents in the treatment of inflammatory diseases

Synaptic mechanisms of pattern completion in the hippocampal CA3 network

The hippocampal CA3 region plays a key role in learning and memory. Recurrent CA3–CA3 synapses are thought to be the subcellular substrate of pattern completion. However, the synaptic mechanisms of this network computation remain enigmatic. To investigate these mechanisms, we combined functional connectivity analysis with network modeling. Simultaneous recording fromup to eight CA3 pyramidal neurons revealed that connectivity was sparse, spatially uniform, and highly enriched in disynaptic motifs (reciprocal, convergence,divergence, and chain motifs). Unitary connections were composed of one or two synaptic contacts, suggesting efficient use of postsynaptic space. Real-size modeling indicated that CA3 networks with sparse connectivity, disynaptic motifs, and single-contact connections robustly generated pattern completion.Thus, macro- and microconnectivity contribute to efficient memory storage and retrieval in hippocampal networks

Parvalbumin+ interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus

Parvalbumin-positive (PV+) GABAergic interneurons in hippocampal microcircuits are thought to play a key role in several higher network functions, such as feedforward and feedback inhibition, network oscillations, and pattern separation. Fast lateral inhibition mediated by GABAergic interneurons may implement a winner-takes-all mechanism in the hippocampal input layer. However, it is not clear whether the functional connectivity rules of granule cells (GCs) and interneurons in the dentate gyrus are consistent with such a mechanism. Using simultaneous patch-clamp recordings from up to seven GCs and up to four PV+ interneurons in the dentate gyrus, we find that connectivity is structured in space, synapse-specific, and enriched in specific disynaptic motifs. In contrast to the neocortex, lateral inhibition in the dentate gyrus (in which a GC inhibits neighboring GCs via a PV+ interneuron) is ~ 10-times more abundant than recurrent inhibition (in which a GC inhibits itself). Thus, unique connectivity rules may enable the dentate gyrus to perform specific higher-order computation

Symmetric spike timing-dependent plasticity at CA3–CA3 synapses optimizes storage and recall in autoassociative networks

CA3–CA3 recurrent excitatory synapses are thought to play a key role in memory storage and pattern completion. Whether the plasticity properties of these synapses are consistent with their proposed network functions remains unclear. Here, we examine the properties of spike timing-dependent plasticity (STDP) at CA3–CA3 synapses. Low-frequency pairing of excitatory postsynaptic potentials (EPSPs) and action potentials (APs) induces long-term potentiation (LTP), independent of temporal order. The STDP curve is symmetric and broad (half-width ~150 ms). Consistent with these STDP induction properties, AP–EPSP sequences lead to supralinear summation of spine [Ca2+] transients. Furthermore, afterdepolarizations (ADPs) following APs efficiently propagate into dendrites of CA3 pyramidal neurons, and EPSPs summate with dendritic ADPs. In autoassociative network models, storage and recall are more robust with symmetric than with asymmetric STDP rules. Thus, a specialized STDP induction rule allows reliable storage and recall of information in the hippocampal CA3 network

Casimir torque

We develop a formalism for the calculation of the flow of angular momentum carried by the fluctuating electromagnetic field within a cavity bounded by two flat anisotropic materials. By generalizing a procedure employed recently for the calculation of the Casimir force between arbitrary materials, we obtain an expression for the torque between anisotropic plates in terms of their reflection amplitude matrices. We evaluate the torque in 1D for ideal and realistic model materials.Comment: 8 pages, 4 figs, Submitted to Proc. of QFEXT'05, to appear in J. Phys.