Service de configuration prédictif pour plateforme multicoeur reconfigurable hétérogène

Cet article décrit un service de gestion des reconfigurations par préchargement prédictif utile pour les architectures multicoeur composées de coeurs reconfigurables hétérogènes. Le but est de masquer les latences de reconfiguration dues aux transferts de bitstreams de grande taille, pour ainsi permettre une plus grande dynamicité de reconfiguration. Nous présentons l'implémentation logicielle du service de préchargement et sa validation fonctionnelle. L'architecture du projet européen Morpheus est utilisée comme exemple pour faire cette validation: nous montrons comment, sur des graphes d'applications simplifiés, masquer complètement le surcoût de la reconfiguration

Lymphome intravasculaire : à propos de deux observations autopsiques et revue de la littérature

Intravacular large B-cell lymphoma (LIV) is a rare entity individualized in the WHO classification since 2001 as a subtype of extranodal diffuse large B-cell lymphoma. We report two autopsic cases of LIV: a 77-year-old woman presenting with fever, dyspnea, antehypophyseal failure and a 54-year-old man presenting with fever, weight-loss, night-sweats and encephalopathy. They died respectively 10 and 7 months after the beginning of symptoms, without diagnosis. Neither infectious disease nor lymphomatous proliferation had been identified. From these two cases and our literature review, we insist on the importance of histopathological diagnosis on biopsy for this rare pathology which clinical diagnosis remains difficult

Scheduling, Binding and Routing System for a Run-Time Reconfigurable Operator Based Multimedia Architecture

International audienceThis article presents an integrated environment for application scheduling, binding and routing used for the run-time reconfigurable, operator based, ROMA multimedia architecture. The environment is very flexible and after a minor modification can support other reconfigurable architectures. Currently, it supports the architecture model composed of a bank of single (double) port memories, two communication networks (with different topologies) and a set of run-time functionally reconfigurable non-pipelined and pipelined operators. The main novelty of this work is simultaneous solving of the scheduling, binding and routing tasks. This frequently generates optimal results, which has been shown by extensive experiments using the constraint programming paradigm. In order to show flexibility of our environment, we have used it in this article for optimization of application scheduling, binding and routing (the case of the non-pipelined execution model) and for space exploration (case of the pipelined execution model)

Exploiting Reconfigurable SWP Operators for Multimedia Applications

International audienceImplementing image processing applications in embedded systems is a difficult challenge due to the drastic constraints in terms of cost, energy consumption and real time execution. Reconfigurable archi- tectures are good candidates to take-up this challenge and especially when the architecture is able to support different word-lengths of pixel through Sub-Word Parallelism (SWP) capabilities. Exploiting the diversity of supported data-types requires automation tools able to optimize the data word-length under an accuracy constraint. In this paper, a new approach for word-length optimization in the case of SWP operations is proposed. Compared to existing approaches the optimization time is significantly reduced without sacrificing the quality of the optimized solution. The results show the ability of our approach to exploit the SWP capabilities associated with multimedia processors

Association of RET codon 691 polymorphism in radiation-induced human thyroid tumours with C-cell hyperplasia in peritumoural tissue

The RET proto-oncogene encodes a protein structurally related to transmembrane receptors with an intracellular tyrosine kinase domain. In human thyroid gland, the RET proto-oncogene is normally expressed in parafollicular C-cells. Thyroid C-cell hyperplasia is associated with inherited medullary thyroid carcinomas and is considered as a pre-neoplastic stage of C-cells disease. It has also been observed in thyroid tissues adjacent to follicular and papillary carcinomas. In order to study the relationship between a misfunctioning of the RET proto-oncogene and the presence of C-cell hyperplasia, we compared a series of thyroid glands presenting sporadic or radiation-associated tumours, as well as samples of unrelated normal thyroid tissues, for alteration in exons 10 and 11 of the gene and for the presence or absence of C-cell hyperplasia. Here we report a significantly higher frequency of C-cell hyperplasia present in peritumoural thyroid tissues of radiation-induced epithelial thyroid tumours, than in peritumoural of sporadic thyroid tumours or in control normal thyroid tissues (P=0.001). A G691S RET polymorphism was present with a higher frequency in radiation-induced epithelial thyroid tumours (55%) than in sporadic tumours (20%) and in control normal thyroid tissues (15%). Interestingly, this polymorphism was associated in the majority (88%) of radiation-induced tumours with a C-cell hyperplasia in the peritumoural tissues. Several explanations for this association are discussed

First landscape of binding to chromosomes for a domesticated mariner transposase in the human genome: diversity of genomic targets of SETMAR isoforms in two colorectal cell lines

Setmar is a 3-exons gene coding a SET domain fused to a Hsmar1 transposase. Its different transcripts theoretically encode 8 isoforms with SET moieties differently spliced. In vitro, the largest isoform binds specifically to Hsmar1 DNA ends and with no specificity to DNA when it is associated with hPso4. In colon cell lines, we found they bind specifically to two chromosomal targets depending probably on the isoform, Hsmar1 ends and sites with no conserved motifs. We also discovered that the isoforms profile was different between cell lines and patient tissues, suggesting the isoforms encoded by this gene in healthy cells and their functions are currently not investigated

LES GROUPEMENTS DE REPRODUCTION CHEZ QUELQUES AMPHIBIENS ANOURES ET LEURS CONSÉQUENCES SUR LA VIE LARVAIRE

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