Efficient vectorization of forward/backward substitutions in solving sparse linear equations

Vector processors have promised an enormous increase in computing speed for computationally intensive and time-critical power system problems which require the repeated solution of sparse linear equations. Due to short vectors processed in these applications, standard sparsity-based algorithms need to be restructured for efficient vectorization. This paper presents a novel data storage scheme and an efficient vectorization algorithm that exploits the intrinsic architectural features of vector computers such as sectioning and chaining. As the benchmark, the solution phase of the Fast Decoupled Load Flow algorithm is used in simulations. The relative performances of the proposed and existing vectorization schemes are evaluated, both theoretically and experimentally, on IBM 3090/VF

Avulsiyon tedavisinde güncel yaklaşımlar

Avulsion is the partially or completely taking out of the tooth from the dental socket; and replantation is replacing the teeth which have been partially or completely avulsed by trauma. Because of the fact that avulsion is such a rare occurrence, dentists are in need of reading the guidelines and getting the posted information on dental association web sites. But unfortunately, even recent guidelines do not address the question of whether it is in the patient’s best interests to replant a tooth. In addition to this, it is important that the merits and shortcomings of clinical guidelines should be understood clearly before they are used to make clinical decisions. In this article, guidelines for management of avulsed teeth are reviewed primarily based on the current literature. ÖZET Travmatik yaralanma sonrası dişin alveoler soketten tamamen çıkmasına avulsiyon, travma sonucu parsiyel veya total olarak alveoler soketten çıkmış olan dişin veya dişlerin tekrar yerine yerleştirilmesine replantasyon adı verilmektedir. Avulsiyon, sık görülen bir olay olmadığından diş hekimi böyle bir durumla karşılaştığında öncelikle bu konuyla ilgili yayınları okumak veya internetten bilgi almak ihtiyacı hissetmektedir. Fakat ne yazık ki son yıllarda yayınlanmış yayınlar bile hastaların hekime diş replantasyonu ile ilgili sorabileceği soruların yanıtlarını tam olarak içermemektedir. Bununla birlikte klinik tedavi prensiplerinin önemi ve kusurları klinik olarak kullanımlarından önce iyice anlaşılmalıdır. Bu makalede, avulsiyon tedavisinde uygulanması önerilen yöntemler güncel literatür ışığında derlenmiştir. Anahtar kelimeler: Dental avulsiyon, replantasyon, dental travma

RACK1 is an interaction partner of ATG5 and a novel regulator of autophagy

Autophagy is biological mechanism allowing recycling of long-lived proteins, abnormal protein aggregates, and damaged organelles under cellular stress conditions. Following sequestration in double- or multimembrane autophagic vesicles, the cargo is delivered to lysosomes for degradation. ATG5 is a key component of an E3-like ATG12-ATG5-ATG16 protein complex that catalyzes conjugation of the MAP1LC3 protein to lipids, thus controlling autophagic vesicle formation and expansion. Accumulating data indicate that ATG5 is a convergence point for autophagy regulation. Here, we describe the scaffold protein RACK1 (receptor activated C-kinase 1, GNB2L1) as a novel ATG5 interactor and an autophagy protein. Using several independent techniques, we showed that RACK1 interacted with ATG5. Importantly, classical autophagy inducers (starvation or mammalian target of rapamycin blockage) stimulated RACK1-ATG5 interaction. Knockdown of RACK1 or prevention of its binding to ATG5 using mutagenesis blocked autophagy activation. Therefore, the scaffold protein RACK1 is a new ATG5-interacting protein and an important and novel component of the autophagy pathways

Avulsiyon tedavisinde güncel yaklaşımlar

<p>Avulsion is the partially or completely taking out of the tooth from the dental socket; and replantation is replacing the teeth which have been partially or completely avulsed by trauma. Because of the fact that avulsion is such a rare occurrence, dentists are in need of reading the guidelines and getting the posted information on dental association web sites. But unfortunately, even recent guidelines do not address the question of whether it is in the patient’s best interests to replant a tooth. In addition to this, it is important that the merits and shortcomings of clinical guidelines should be understood clearly before they are used to make clinical decisions. In this article, guidelines for management of avulsed teeth are reviewed primarily based on the current literature.</p> <p><strong> </strong></p> <p><strong>ÖZET</strong></p> <p>Travmatik yaralanma sonrası dişin alveoler soketten tamamen çıkmasına avulsiyon, travma sonucu parsiyel veya total olarak alveoler soketten çıkmış olan dişin veya dişlerin tekrar yerine yerleştirilmesine replantasyon adı verilmektedir. Avulsiyon, sık görülen bir olay olmadığından diş hekimi böyle bir durumla karşılaştığında öncelikle bu konuyla ilgili yayınları okumak veya internetten bilgi almak ihtiyacı hissetmektedir. Fakat ne yazık ki son yıllarda yayınlanmış yayınlar bile hastaların hekime diş replantasyonu ile ilgili sorabileceği soruların yanıtlarını tam olarak içermemektedir. Bununla birlikte klinik tedavi prensiplerinin önemi ve kusurları klinik olarak kullanımlarından önce iyice anlaşılmalıdır. Bu makalede, avulsiyon tedavisinde uygulanması önerilen yöntemler güncel literatür ışığında derlenmiştir.</p> <p><strong>Anahtar kelimeler: </strong>Dental avulsiyon, replantasyon, dental travma.</p&gt

Oral and dental findings of griscelli syndrome type 3

Griscelli syndrome (GS) is a rare autosomal recessive genetic disorder characterized by variable immunodeficiency, partial albinism, abnormal accumulation of melanosomes in melanocytes, pigmentary dilution of the skin, and shiny silver-gray hair. GS has three types, with the first and second types caused by mutations in two genes being located at band 15q21: RAB27A and MYO5A. The expression of the third form of GS is restricted to the characteristic hypopigmentation of GS, and results from mutation in the gene that encodes melanophilin MLPH. It has also been shown that an identical phenotype can result from the deletion of the MYO5A F-exon. The aim of this case report is the presentation of oral and dental features and SEM images of the hair of a 12-year-old girl with GS type 3. [Arch Clin Exp Surg 2015; 4(3.000): 164-167

A New Multiplex PCR Method for Rapid Detection of Genes Encoding VIM and IMP Types of Metallo Beta Lactamases

Objective: This study describes a multiplex polymerase chain reaction (PCR) assay protocol for rapid detection of genes encoding VIM and IMP types of metallo beta lactamases (MBL). This assay is also used for evaluate the presence and types of MBL among Pseudomonas aeruginosa isolates in a large university hospital in Istanbul. Material and Methods: bla IMP1-22 and blaVIM1-12 prototype sequences were downloaded from GenBank and aligned using ClustalW multiple alignment program in Bioedit software package. Following optimisation using different concentrations and combination of primers, the 1.2 VIM/IMP ratio for primers were determined and used throughout the screening assays. The multiplex PCR protocol was used to screen 51 P.aeruginosa isolates resistant or intermediate resistant to imipenem. Minimum inhibitory concentrations (MIC) of imipenem, meropenem, ceftazidime and cefepime were determined by the agar dilution method. Control strains comprised of P.aeruginosa strains producing IMP-1, IMP-2, IMP13, VIM-1, VIM-2, VIM-4 and a Klebsiella pneumoniae strain producing VIM-5. Results: The multiplex PCR method was able to detect all the control strains producing VIM and IMP types of MBL genes. No isolate was found to be positive for bla VIM and bla IMP genes among 51 P.aeruginosa isolates with the multiplex PCR method. MIC50 values for P.aeruginosa isolates of imipenem, meropenem, ceftazidime and cefepime were 32 mu g/ml, 32 mu g/ml, 128 mu g/ml, 64 mu g/ml, respectively. Conclusion: The multiplex PCR assay described in this study could be helpful for monitoring the epidemiology of VIM and IMP types of MBL in different clinical settings