2,743 research outputs found
Thermal Impact on Spiking Properties in Hodgkin-Huxley Neuron with Synaptic Stimulus
The effect of environmental temperature on neuronal spiking behaviors is
investigated by numerically simulating the temperature dependence of spiking
threshold of the Hodgkin-Huxley neuron subject to synaptic stimulus. We find
that the spiking threshold exhibits a global minimum in a "comfortable
temperature" range where spike initiation needs weakest synaptic strength,
indicating the occurrence of optimal use of synaptic transmission in neural
system. We further explore the biophysical origin of this phenomenon in ion
channel gating kinetics and also discuss its possible biological relevance in
information processing in neural systems.Comment: 10 pages, 4 figure
How similar are the different results?
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43555/1/11135_2004_Article_BF00145805.pd
Thermopower of Aharonov-Bohm Interferometer with a Quantum Dot
We report on the thermopower of an Aharonov-Bohm interferometer (AB) with a
quantum dot in the Kondo limit. The thermopower is anomalously enhanced due to
the Kondo effect as in heavy fermion systems. In contrast to the bulk systems,
the sign of the thermopower can be changed by adjusting the energy level scheme
or the particle-hole asymmetry of a dot with the gate voltage. Further the
magnitude and even the sign of the thermopower in the AB ring can be changed at
will with varying either magnetic fields or the gate voltages.Comment: 4 pages, 3 figures, accepted for publication in Physical Review
Letter
Integrative Genomics Viewer
Author Manuscript 2012 May 07.To the Editor:
Rapid improvements in sequencing and array-based platforms are resulting in a flood of diverse genome-wide data, including data from exome and whole-genome sequencing, epigenetic surveys, expression profiling of coding and noncoding RNAs, single nucleotide polymorphism (SNP) and copy number profiling, and functional assays. Analysis of these large, diverse data sets holds the promise of a more comprehensive understanding of the genome and its relation to human disease. Experienced and knowledgeable human review is an essential component of this process, complementing computational approaches. This calls for efficient and intuitive visualization tools able to scale to very large data sets and to flexibly integrate multiple data types, including clinical data. However, the sheer volume and scope of data pose a significant challenge to the development of such tools.National Institute of General Medical Sciences (U.S.) (R01GM074024)National Cancer Institute (U.S.) (R21CA135827)National Human Genome Research Institute (U.S.) (U54HG003067
Offenders' Crime Narratives across Different Types of Crimes
The current study explores the roles offenders see themselves playing during an offence and their relationship to different crime types. One hundred and twenty incarcerated offenders indicated the narrative roles they acted out whilst committing a specific crime they remembered well. The data were subjected to Smallest Space Analysis (SSA) and four
themes were identified: Hero, Professional, Revenger and Victim in line with the recent theoretical framework posited for Narrative Offence Roles (Youngs & Canter, 2012). Further analysis showed that different subsets of crimes were more like to be associated with different narrative offence roles. Hero and Professional were found to be associated with property offences (theft, burglary and shoplifting), drug offences and robbery and Revenger
and Victim were found to be associated with violence, sexual offences and murder. The theoretical implications for understanding crime on the basis of offenders' narrative roles as well as practical implications are discussed
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The stealth episome: suppression of gene expression on the excised genomic island PPHGI-1 from Pseudomonas syringae pv. phaseolicola
Pseudomonas syringae pv. phaseolicola is the causative agent of halo blight in the common bean, Phaseolus vulgaris. P. syringae pv. phaseolicola race 4 strain 1302A contains the avirulence gene avrPphB (syn. hopAR1), which resides on PPHGI-1, a 106 kb genomic island. Loss of PPHGI-1 from P. syringae pv. phaseolicola 1302A following exposure to the hypersensitive resistance response (HR) leads to the evolution of strains with altered virulence. Here we have used fluorescent protein reporter systems to gain insight into the mobility of PPHGI-1. Confocal imaging of dual-labelled P. syringae pv. phaseolicola 1302A strain, F532 (dsRFP in chromosome and eGFP in PPHGI-1), revealed loss of PPHGI-1::eGFP encoded fluorescence during plant infection and when grown in vitro on extracted leaf apoplastic fluids. Fluorescence-activated cell sorting (FACS) of fluorescent and non-fluorescent PPHGI-1::eGFP F532 populations showed that cells lost fluorescence not only when the GI was deleted, but also when it had excised and was present as a circular episome. In addition to reduced expression of eGFP, quantitative PCR on sub-populations separated by FACS showed that transcription of other genes on PPHGI-1 (avrPphB and xerC) was also greatly reduced in F532 cells harbouring the excised PPHGI-1::eGFP episome. Our results show how virulence determinants located on mobile pathogenicity islands may be hidden from detection by host surveillance systems through the suppression of gene expression in the episomal state
Spatial patterns and temporal variability of drought in Western Iran
An analysis of drought in western Iran from 1966 to 2000 is presented
using monthly precipitation data observed at 140 gauges uniformly distributed over
the area. Drought conditions have been assessed by means of the Standardized
Precipitation Index (SPI). To study the long-term drought variability the principal
component analysis was applied to the SPI field computed on 12-month time scale.
The analysis shows that applying an orthogonal rotation to the first two principal
component patterns, two distinct sub-regions having different climatic variability
may be identified. Results have been compared to those obtained for the largescale
using re-analysis data suggesting a satisfactory agreement. Furthermore, the
extension of the large-scale analysis to a longer period (1948–2007) shows that
the spatial patterns and the associated time variability of drought are subjected
to noticeable changes. Finally, the relationship between hydrological droughts in
the two sub-regions and El Niño Southern Oscillation events has been investigated
finding that there is not clear evidence for a link between the two phenomen
Spike-Train Responses of a Pair of Hodgkin-Huxley Neurons with Time-Delayed Couplings
Model calculations have been performed on the spike-train response of a pair
of Hodgkin-Huxley (HH) neurons coupled by recurrent excitatory-excitatory
couplings with time delay. The coupled, excitable HH neurons are assumed to
receive the two kinds of spike-train inputs: the transient input consisting of
impulses for the finite duration (: integer) and the sequential input
with the constant interspike interval (ISI). The distribution of the output ISI
shows a rich of variety depending on the coupling strength and the
time delay. The comparison is made between the dependence of the output ISI for
the transient inputs and that for the sequential inputs.Comment: 19 pages, 4 figure
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