Evidencias geol\uf3gicas, geomorfol\uf3gicas y geof\uedsicas de deformaci\uf3n asociada a la falla Cerritos y su implicaci\uf3n en el peligro s\uedsmico de Morelia, Michoac\ue1n, M\ue9xico

The Cerritos fault is located SW of Morelia city, in the state of Michoac\ue1n, M\ue9xico. The fault belongs to the western part of the Morelia-Acambay Fault System, an area with several active segmented faults that form various grabens and half-grabens. In this area, faulting affects Miocene to Holocene lithologies; some of these faults even control the distribution of regional monogenetic volcanoes. This work is an interdisciplinary approach to characterize the Cerritos fault, an important structure with a high seismic hazard potential. The Cerritos fault is a 12 km-long oblique fault (normal-left lateral) with a 130\ub15 m-high topographic relief (100 m of surface displacement + 30 m of subsurface displacement estimated from the inverted resistivity study). This fault is ENE-WSW oriented (255\ub0), with a 76\ub0 NNW dip. In a well\u2010exposed cross section of the Cerritos fault, a few meters from the master fault trace, a colluvial wedge with organic material was identified, yielding a radiocarbon age of 3.37-3.21 cal ka BP. Our geologic and geomorphological analyses indicate that the Cerritos fault is a young, tectonically-active fault, especially in its eastern part. The vertical and horizontal linearity of the fault scarp and the accumulation of lake deposits in the down-thrown block suggest active vertical motion (uplift and subsidence, respectively) along this fault. Geophysical surveys, including seismic refraction, terrestrial magnetometry, and electrical resistivity tomography, show the subsurface geometry of the fault to be characterized by a main listric fault plane and a damage zone in the footwall block, extending as far as 75 m from the main scarp. The damage zone is characterized by secondary, synthetic, and antithetic faults, forming roll-over anticlines and two crestal collapse grabens that accumulate colluvial material. Paleoseismic estimates of activity and seismic hazard potential indicate that the Cerritos fault has a slip-rate of 0.03\ub10.01 mm/yr, with mean vertical displacements of 0.5 m per event and a mean recurrence interval of 16 700 years. The Cerritos fault can generate single-segment ruptures with magnitudes of MW 6.2 to 6.6. Still, in a worst-case scenario, it could also rupture with the subparallel and adjacent Morelia and Cointzio faults, generating earthquake magnitudes up to MW 6.9

Evaluating the incidence of pathological complete response in current international rectal cancer practice: the barriers to widespread safe deferral of surgery

This is the peer reviewed version of the following article: , which has been published in final form at https://doi.org/10.1111/codi.14361. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."Colorectal Disease © 2018 The Association of Coloproctology of Great Britain and Ireland Introduction: The mainstay of management for locally advanced rectal cancer is chemoradiotherapy followed by surgical resection. Following chemoradiotherapy, a complete response may be detected clinically and radiologically (cCR) prior to surgery or pathologically after surgery (pCR). We aim to report the overall complete pathological response (pCR) rate and the reliability of detecting a cCR by conventional pre-operative imaging. Methods: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients treated by elective rectal resection were included. A pCR was defined as a ypT0 N0 EMVI negative primary tumour; a partial response represented any regression from baseline staging following chemoradiotherapy. The primary endpoint was the pCR rate. The secondary endpoint was agreement between post-treatment MRI restaging (yMRI) and final pathological staging. Results: Of 2572 patients undergoing rectal cancer surgery in 277 participating centres across 44 countries, 673 (26.2%) underwent chemoradiotherapy and surgery. The pCR rate was 10.3% (67/649), with a partial response in 35.9% (233/649) patients. Comparison of AJCC stage determined by post-treatment yMRI with final pathology showed understaging in 13% (55/429) and overstaging in 34% (148/429). Agreement between yMRI and final pathology for T-stage, N-stage, or AJCC status were each graded as ‘fair’ only (n = 429, Kappa 0.25, 0.26 and 0.35 respectively). Conclusion: The reported pCR rate of 10% highlights the potential for non-operative management in selected cases. The limited strength of agreement between basic conventional post-chemoradiotherapy imaging assessment techniques and pathology suggest alternative markers of response should be considered, in the context of controlled clinical trials