4 research outputs found

    Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin

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    Cutaneous squamous cell carcinoma (cSCC) is a skin cancer that normally progresses from UV-induced actinic keratosis (AK). Here, the authors investigate the epigenomics of cSCC and highlight two distinct subclasses of AK and cSCC originating from distinct keratinocyte differentiation stages
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