Study of the effect of a drug from the macromycetes Ganoderma lucidum on the phagocytic activity of peripheral blood neutrophils in patients with year-round allergic rhinitis

Modern complex therapy of patients with persistent (year-round, chronic) allergic rhinitis (AR), based on the use of antihistamines and intranasal glucocorticosteroids, in many cases is not effective enough, since drug therapy acts only on individual links in the pathogenesis, without preventing the progression of the allergic disease. At the same time, the quantitative and reserve capabilities of neutrophil granulocytes are depleted, which increases the level of antigenic load in patients with AR. The aim of this study is to investigate the phagocytic activity of neutrophils in patients with AR who received basic therapy and patients who received basic therapy and a course of the drug from the macromycetes Ganoderma lucidum "Astmagan". We examined 40 patients of both sexes with AR, the duration of the disease ranged from 6 months to 2 years. Patients were divided into 2 equal groups: The 1st group consisted of patients who received basic therapy (oral Loratadine and intranasal Nasonex). The 2nd group consisted of patients who received basic therapy and a course of "Astmagan". The treatment course lasted 90 days. The control group consisted of 25 healthy individuals. After the treatment, patients in both groups showed a statistically significant positive dynamics of phagocytic system activity: in group 1, the phagocytic index (FI) increased by 30 % (p=0.001), in the second group this indicator reached the normal level. Also, in patients of group 1, the phagocytic number (PN) increased by 35 % (p=0.0001), but did not reach the normal level. According to the results of comparative evaluation, a greater efficacy of the treatment complex with the additional use of "Astmagan" was established, which is manifested in the restoration of phagocytic activity of peripheral blood neutrophils, the effect persists for 6 months after treatment

Study of the effect of external use of a brown algae product on the structural-functional continuum

The authors, in a study on 25 outbred Wistar white rats weighing 180-200 g, determined the effect of Lamidana (a product from sea brown algae) on the structural-functional continuum, that is, the correlation of the functional activity of the liver parenchyma and its structural characteristics. Methods. The detoxifying function of the liver was studied by the duration of sleep of animals due to the action of anesthesia - intraperitoneal administration of sodium thiopental (estimate the rate of metabolism of thiopental, carried out by the cytochrome-P-450-dependent monooxygenase system of hepatocytes). The structural and functional state of the liver parenchyma was assessed according to the study of histological preparations. The results of the studies showed that under the influence of the external application of "Lamidin" in the test rats, the liver1s detoxification function is enhanced (significantly significant decrease in the duration of sleep of animals). At the same time, structural signs of increased functional activity of hepatocytes are determined in the parenchyma. Conclusions. The authors believe that "Lamidan", due to the peculiarities of its chemical composition, enhances the metabolic and functional activity of hepatocytes but does not damage the correlative relationships between the structure and function of hepatocytes

Assessment of the state of synergies between the structural and functional characteristics of the kidneys and liver during external use of a seaweed product Laminaria algae

The authors conducted studies to study the relationship between the functional activity of the kidneys, the detoxification activity of the liver and the structural features of the parenchymatous tissue of these organs under normal conditions and with external use of the laminar algae product “Lamidan”. The work was performed on 164 white outbred Wistar rats weighing 180-200 g. The work was carried out in accordance with current standards for working with laboratory animals. The results of many years of research have shown that normally the indicators of detoxification activity of the liver and functional activity of the kidneys practically do not change, and they correspond to the structural organization of the parenchymatous tissue of these organs, corresponding to the descriptions given in well-known manuals on the activities of these organs. The use of "Lamidan" activates the detoxification function of the liver by 28 % and the functional activity of the kidneys by 28.5 %, i.e. changes are unidirectional and proportionate. In the parenchyma of both organs, changes in the structural organization are recorded, characteristic of an increase in functional activity. Thus, there is a strictly interrelated set of stereotypical changes in the indices of the two organs under study, reflecting between the organs interrelations of functional systems

Influence of millimeter electromagnetic waves on the functional capabilities of the lower limb muscles in athletes - volleyball players

The authors, when observing 22 athletes - volleyball players of different volleyball specialization, assessed the effect of millimeter electromagnetic waves (EMW) on the functional state of the muscular system of the lower extremities. The electromagnetic effect was carried out using the "Complex SP 80" apparatus (frequencies 3900 - 4120 kHz were used). Electrodes were applied to the muscles of the thigh and lower leg, sinusoidal discharges were applied for 10 seconds during the strength training period. The results of observations showed that under the influence of EME, the height of the jump increases by 7%, due to the increase in the energy of the jump and its intensity. The release of the activity of the knee joint is also noted. The authors believe that under the influence of EME, the transmission of regulatory impulses in neuromuscular contact improves, which contributes to the synchronization and strength of contractions of the muscle fiber bundles. Also, under the influence of EMW, blood microcirculation in the muscle improves

Features of the reaction of the kidney function of healthy rats to the intake of boric hydrocarbonate sodium mineral waters of varying quantitative macro- and micro-composition

The purpose of the work is a comparative assessment of the effect of boron hydrocarbonate sodium mineral waters with a varying quantitative and qualitative composition of macroelements and with different amounts of a bioactive element on the state of the urinary system of rats. Materials and methods. The work was performed on 81 white rats of the Wistar line of auto bred breeding, weighing 180-200 g. The rats were divided into four groups: group 1 - 21 intact rats served as controls; group 2 - 20 rats treated intragastrically with a soft probe MW "Polyana Ploskivskaya" at a dose of 1% of body weight daily, a course of 7 days; group 3 - 20 rats treated with MW "Polyana Kupel" according to the above method; group 4 - 20 rats treated with MW "Svalyava" according to the above process. Before removing the animals from the experiment, daily urine was collected from them; blood was also taken from the tail vein for biochemical studies. At autopsy, pieces of kidneys were taken for histological and histoenzymological studies (the activity of succinate dehydrogenase and lactate dehydrogenase was determined). Results. The histological studies showed no pathological changes in the kidneys were observed with the use of the studied boron MW. Still, there were structural changes, as well as an increase in the activity of redox enzymes. Changes in kidney function were unidirectional with using any of the investigated MW. Still, they had quantitative differences, which are less related to the amount of boron (in the form of orthoboric acid) in 1 liter of MW and more dependent on the osmolarity of the MW, the qualitative composition of macronutrients, and their ratio. Conclusion. We believe that osmolarity, as an integrated indicator of the state of the macronutrient component of MW, can be used to assess its effect on the structural and functional characteristics of the kidneys

Perspectiveness of correction of accompanying diseases in patients with autism by course of interior use of naturally low mineralized water

The article reviews the pathogenesis and the course of autism. Authors define autism as a psychosomatic disorder. A distinctive feature of mineral waters, as natural therapeutic factors of weak intensity, is their pronounced biological activity, the absence of side effects and the possibility of long-term use in combination with medication therapy. The paper presents data substantiating the possibility of using mineral water with an increased content of organic substances for the correction of the somatic component of autism (problems of the gastrointestinal tract, carbohydrate metabolism disorders, neurosis)

Comparative evaluation of the effectiveness of natural silicon mineral waters and their artificial analogics on the current experimental patiology of sleeve-surface tract

The article presents data on the effect of silicon-containing mineral waters (MW) and their artificial analogues with the corresponding content of metasilicic acid on the state of the stomach wall in the modeling of gastritis in white rats. It was established that the use of MW with different content of metasilicic acid has a unidirectional, positive effect on the course of gastritis. MW with greater mineralization, molarity and high content of methacrylic acid completely eliminate inflammation and moderately stimulate reparative processes. In the application of MW with less mineralization, molarity and lower content of metasilicic acid, there were definitive inflammation manifestations, but the manifestations of reparative processes were more pronounced. The same trend was observed with the use of artificial analogues - model solutions on distilled water with the corresponding content of metasilicic acid. It is determined the same restorative in the direction, but much weaker corrective effect than the corresponding MW. The important component of the corrective action of these silicon MW when used in animals with gastritis is determined by the peculiarities of the macro component composition and the proportion of the main macro components - Na +, K +, Mg2 +, Ca2 +, НСО3, Cl-, SO42- and, to a lesser extent, silicon content

Study of the effect of external use of a brown algae product on the structural-functional continuum

Nasibullin B. A., Gushcha S. G., Dekhtyar Yu. N., Volyanska V. S. Study of the effect of external use of a brown algae product on the structural-functional continuum. Journal of Education, Health and Sport. 2023;47(1):75-83. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.47.01.007 https://apcz.umk.pl/JEHS/article/view/46248 https://zenodo.org/record/8364684 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of 17.07.2023 No. 32318. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 17.07.2023 Lp. 32318. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 29.07.2023. Revised:21.08.2023. Accepted: 28.08.2023. Published: 29.08.2023. Study of the effect of external use of a brown algae product on the structural-functional continuum B. A. Nasibullin, S. G. Gushcha, Yu. N. Dekhtyar, V. S. Volyanska State Institution «Ukrainian Research Institute of Medical Rehabilitation and Resort Therapy of the Ministry of Health of Ukraine», Odesa, Ukraine Boris Nasibullin: ORCID https://orcid.org/0000-0003-3963-2374; e-mail: [email protected] Sergey Gushcha: ORCID https://orcid.org/0000-0003-3097-5258; e-mail: [email protected] Veronika Volyanska: ORCID https://orcid.org/0000-0002-3019-7620; e-mail: [email protected] Abstract The authors, in a study on 25 outbred Wistar white rats weighing 180-200 g, determined the effect of Lamidana (a product from sea brown algae) on the structural-functional continuum, that is, the correlation of the functional activity of the liver parenchyma and its structural characteristics. Methods. The detoxifying function of the liver was studied by the duration of sleep of animals due to the action of anesthesia - intraperitoneal administration of sodium thiopental (estimate the rate of metabolism of thiopental, carried out by the cytochrome-P-450-dependent monooxygenase system of hepatocytes). The structural and functional state of the liver parenchyma was assessed according to the study of histological preparations. The results of the studies showed that under the influence of the external application of "Lamidin" in the test rats, the liver1s detoxification function is enhanced (significantly significant decrease in the duration of sleep of animals). At the same time, structural signs of increased functional activity of hepatocytes are determined in the parenchyma. Conclusions. The authors believe that "Lamidan", due to the peculiarities of its chemical composition, enhances the metabolic and functional activity of hepatocytes but does not damage the correlative relationships between the structure and function of hepatocytes. Keywords: product from brown algae; liver; structural-functional continuum

Influence of mineral water on the structural and functional state of the rats kidneys with metabolic syndrome

In white rats in the setting of development of metabolic syndrome inhibition of the urinary and excretory functions of the kidney, with impaired water-ion balance (the kidneys excrete slightly hyperosmotic urine in a small amount) on the background of structural signs of dystrophies. Daily diuresis is reduced by 37% due to a decrease in glomerular filtration rate (GFR) by 22% and an increase in the percentage of tubular reabsorption (p <0.001), excretion of creatinine, urea and chloride decreased by 22%, 15% and 56%. The excretion of potassium and sodium ions increases by 14% and 38%, respectively. The daily urine is greatly delayed. Two-week internal course administration of lowmineralized sodium chloride water has a positive effect on impaired renal function: the volume of diuresis is increased by 15% by accelerating GFR by 20% and restoring the value of tubular reabsorption. Creatinine excretion is increased by 20% and urea by 32%. The excretion of potassium and sodium ions is increased by 50% and 166%, respectively. Excretion of chloride ions and urine pH is fully restored. Microscopically determined residual manifestations of dystrophic processes in the kidneys, which against the background of the recovery of processes of urination and stimulation of ion-regulating and excretory functions of the kidneys, indicates the ability of the applied sodium chloride MW to correct the structural and functional disorders of the metabolic syndrome

Correction of magnesium deficiency in the body with balneological means: experimental studies

In the modern world, a lack of magnesium in the body is one of the most common deficient conditions in humans. Low levels of magnesium have been associated with a number of chronic diseases. This work is devoted to the study of the effect of the use of the balneological means "Magnesium oil" for the correction of the manifestations of experimentally induced magnesium deficiency. The experiment was conducted on 50 white female rats of the Wistar auto-breeding line which were divided into 3 equal groups: (1) control, (2) model of magnesium deficiency, (3) received "Magnesium oil". As a result of modeling the state of magnesium deficiency, significant changes are observed in the central nervous system, vegetative nervous system, and kidneys of animals. The use of balneological means "Magnesium oil" can significantly reduce the negative manifestations of magnesium deficiency