Econometric modelling of enterprise financial activity

The article considers specific features of application of vector auto-regression technologies and models of error correcting in the study of strategic financial position of an enterprise. It offers an algorithm of selection of the method of forecasting interconnected financial indicators. It develops dynamic systems of indicators of external and internal financial environment of an enterprise. The obtained results could be used in strategic management of the enterprise financial activity

Development of the draft standard of organization «VALUE STREAM MAPPING»

The standard of organization « Value Stream Mapping» at the Kalinin Machine-Building Plant is developed. Using this standard, the enterprise will be able to reduce working losses, to increase production effectiveness and to take the leading positions in the marketРазработан проект стандарта организации «Картирование потока создания ценности» на ПАО «Машиностроительный завод имени М. И. Калинина». Используя данный стандарт, предприятие сможет сократить производственные потери, повысить производственную эффективность и занять лидирующие позиции на рынк

Novel LRBA Mutation and Possible Germinal Mosaicism in a Slavic Family

Peer reviewe

Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells

DNMT3A mutations are observed in myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). Transplantation studies have elucidated an important role for Dnmt3a in stem cell self-renewal and in myeloid differentiation. Here we investigated the impact of conditional hematopoietic Dnmt3a loss on disease phenotype in primary mice. Mx1-Cre-mediated Dnmt3a ablation led to the development of a lethal, fully penetrant myeloproliferative neoplasm with myelodysplasia (MDS/MPN) characterized by peripheral cytopenias and by marked, progressive hepatomegaly. We detected expanded stem/progenitor populations in the liver of Dnmt3a-ablated mice. The MDS/MPN induced by Dnmt3a ablation was transplantable, including the marked hepatomegaly. Homing studies showed that Dnmt3a-deleted bone marrow cells preferentially migrated to the liver. Gene expression and DNA methylation analyses of progenitor cell populations identified differential regulation of hematopoietic regulatory pathways, including fetal liver hematopoiesis transcriptional programs. These data demonstrate that Dnmt3a ablation in the hematopoietic system leads to myeloid transformation in vivo, with cell autonomous aberrant tissue tropism and marked extramedullary hematopoiesis (EMH) with liver involvement. Hence, in addition to the established role of Dnmt3a in regulating self-renewal, Dnmt3a regulates tissue tropism and limits myeloid progenitor expansion in vivo

Method for the Synthesis of a Composition Based on Aluminum Oxide and a Solid Solution of Cerium and Zirconium Oxides

FIELD: metallurgy. SUBSTANCE: invention relates to methods for producing composite powder materials by hydrometallurgical method, namely, to compositions based on stabilized aluminum oxide and a solid solution of cerium and zirconium oxides, which can be used as carriers of the catalytically active phase in an automotive catalytic unit. A method for synthesizing a composition based on aluminum oxide and a solid solution of cerium and zirconium oxides includes the preparation of an aqueous suspension of cerium, zirconium and possibly yttrium or lanthanum hydroxides with a pH of 7 to 10 with the addition of ammonia at room temperature, the preparation of an aqueous suspension of aluminum hydroxides and possibly zirconium or lanthanum at room temperature. Next, the resulting suspensions are mixed at room temperature to produce a total suspension. The precipitate is separated from the mother liquor and isopropyl alcohol is injected. The mixture is dried and burnt. Before separating the precipitate from the mother liquor, the total suspension is ground so that the D90 value is less than 9.5 mcm, or subjected to hydrothermal treatment at a temperature above 110°C with the duration of 0 hours or more. EFFECT: increase in the thermal stability of the surface of the particles of the composite powder material is provided. 8 cl, 1 dwg, 6 ex.Изобретение относится к способам получения композиционных порошковых материалов гидрометаллургическим способом, а именно к композициям на основе стабилизированного оксида алюминия и твердого раствора оксидов церия и циркония, которые могут быть применены как носители каталитически активной фазы в автомобильном каталитическом блоке. Способ синтеза композиции на основе оксида алюминия и твердого раствора оксидов церия и циркония включает приготовление водной суспензии гидроксидов церия, циркония и, возможно, иттрия или лантана с рН от 7 до 10 добавлением аммиака при комнатной температуре, приготовление водной суспензии гидроксидов алюминия и, возможно, циркония или лантана при комнатной температуре. Далее смешивают полученные суспензии при комнатной температуре с получением общей суспензии. Отделяют осадок от маточного раствора и вводят изопропиловый спирт. Сушат и обжигают. Причем до отделения осадка от маточного раствора общую суспензию подвергают помолу так, чтобы значение D90 составляло менее 9,5 мкм, или подвергают гидротермальной обработке при температуре выше 110°С длительностью от 0 часов и более. Обеспечивается повышение термической стабильности поверхности частиц композиционного порошкового материала. 2 н. и 6 з.п. ф-лы, 1 ил., 6 пр

STUDY OF THE INFLUENCE OF THE SYNTHESIS METHOD ON THE SURFACE PROPERTIES OF SOLID SOLUTIONS BASED ON ZIRCONIUM AND CERIUM OXIDES

The effect of the pH of the synthesis and subsequent treatment of solid solutions of zir-conium and cerium on the specific surface area was investigated.Работа частично поддержана проектом FEUZ-2020-0059 Минобрнауки РФ

STUDY OF PROPERTIES OF OXIDE AND HYBRID LUMINOPHERS BASED ON Gd-Eu

Oxide and hybrid phosphors based on Gd-Eu with a molar ratio of europium-ions to the sum of REE-ions in powders of 0,01 and 0,1 were synthesized. Oxide phosphors significantly outperform hybrid phosphors in luminosity. The luminosity increases with increasing euro-pium content in the sample.Работа частично поддержана проектом FEUZ-2020-0059 Минобрнауки РФ

Enhancement of COPD biological networks using a web-based collaboration interface

The construction and application of biological network models is an approach that offers a holistic way to understand biological processes involved in disease. Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory disease of the airways for which therapeutic options currently are limited after diagnosis, even in its earliest stage. COPD network models are important tools to better understand the biological components and processes underlying initial disease development. With the increasing amounts of literature that are now available, crowdsourcing approaches offer new forms of collaboration for researchers to review biological findings, which can be applied to the construction and verification of complex biological networks. We report the construction of 50 biological network models relevant to lung biology and early COPD using an integrative systems biology and collaborative crowd-verification approach. By combining traditional literature curation with a data-driven approach that predicts molecular activities from transcriptomics data, we constructed an initial COPD network model set based on a previously published non-diseased lung-relevant model set. The crowd was given the opportunity to enhance and refine the networks on a website ( https://bionet.sbvimprover.com/) and to add mechanistic detail, as well as critically review existing evidence and evidence added by other users, so as to enhance the accuracy of the biological representation of the processes captured in the networks. Finally, scientists and experts in the field discussed and refined the networks during an in-person jamboree meeting. Here, we describe examples of the changes made to three of these networks: Neutrophil Signaling, Macrophage Signaling, and Th1-Th2 Signaling. We describe an innovative approach to biological network construction that combines literature and data mining and a crowdsourcing approach to generate a comprehensive set of COPD-relevant models that can be used to help understand the mechanisms related to lung pathobiology. Registered users of the website can freely browse and download the networks

Quantum majorization and a complete set of entropic conditions for quantum thermodynamics

What does it mean for one quantum process to be more disordered than another? Interestingly, this apparently abstract question arises naturally in a wide range of areas such as information theory, thermodynamics, quantum reference frames, and the resource theory of asymmetry. Here we use a quantum-mechanical generalization of majorization to develop a framework for answering this question, in terms of single-shot entropies, or equivalently, in terms of semi-definite programs. We also investigate some of the applications of this framework, and remarkably find that, in the context of quantum thermodynamics it provides the first complete set of necessary and sufficient conditions for arbitrary quantum state transformations under thermodynamic processes, which rigorously accounts for quantum-mechanical properties, such as coherence. Our framework of generalized thermal processes extends thermal operations, and is based on natural physical principles, namely, energy conservation, the existence of equilibrium states, and the requirement that quantum coherence be accounted for thermodynamically