Comparative review of biochemistry and cell anatomy of the hepatic tissue in rats administered some anti hypertensive drug for a long time

The adverse biochemical and structural effects of antihypertensive drugs over a long period (clonidine, methyldopa, rilmenidine, amlodipine, ramipril) on hepatic tissue has been examined in this study. The results are considered to be beneficial for the identification of indications and contraindications in hypertensive patients. Severe bile duct proliferation, portal inflammation, interface hepatitis, focal necrosis and hepatocyte degeneration were demonstrated in the clonidine and amlodipine groups, which had higher oxidant parameters, aspartate aminotransferase, alanine amino transferase and lactate dehydrogenase activity and a higher amount of 8-OH Gua. In the group receiving rilmenidine, all the histopathological findings were the same as those in the clonidine and amlodipine groups, except for bile duct proliferation and interface hepatitis. On histopathological examination of the cell anatomy, it was shown that methyldopa and ramipril caused mild liver damage. While clonidine and amlodipine gave rise to severe liver damage, rilmenidine caused moderate damage, and methyldopa and ramipril led to mild loss of liver function.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Post-Traumatic Glioblastoma Multiforme: A Case Report

Malignant glioma development after trauma is a rare occurrence. We report a glioblastoma multiforme case that developed after a depressed skull fracture. A 65-year-old man was admitted because of right sided hemiplegia, epilepsy and changes in consciousness due to a malignant glial tumor. He had been operated on for a left calvarial depression fracture caused by cerebral laceration thirty-five years before. Radiologic imaging revealed a large contrast-enhanced mass lesion at the left frontotemporoparietal junction under the depression site. The patient underwent urgent surgery, and radical excision of the mass was achieved. The histopathologic diagnosis was a high-grade glial tumor. Although the possibility of a pre-existing tumor rather than a trauma-induced tumor is very high, the presented case suggests that traumatic cerebral lesions may also be a predisposing factor for the development of malignant glial tumors

Post-Traumatic Glioblastoma Multiforme: A Case Report

Malignant glioma development after trauma is a rare occurrence. We report a glioblastoma multiforme case that developed after a depressed skull fracture. A 65-year-old man was admitted because of right sided hemiplegia, epilepsy and changes in consciousness due to a malignant glial tumor. He had been operated on for a left calvarial depression fracture caused by cerebral laceration thirty-five years before. Radiologic imaging revealed a large contrast-enhanced mass lesion at the left frontotemporoparietal junction under the depression site. The patient underwent urgent surgery, and radical excision of the mass was achieved. The histopathologic diagnosis was a high-grade glial tumor. Although the possibility of a pre-existing tumor rather than a trauma-induced tumor is very high, the presented case suggests that traumatic cerebral lesions may also be a predisposing factor for the development of malignant glial tumors

Reactions of connective tissue to self-etching/priming dentin bonding systems: oxidative stress, tumor necrosis factor a expression, and tissue reactions

ERCAN, Ertugrul/0000-0002-4753-6553WOS: 000270695000005Background/purpose: Few data have been published concerning tissue and systemic responses to resinous dental materials. The aim of this study was to compare and evaluate the biocompatibility of four kinds of dental self-etching/priming adhesives by measuring tissue responses, local and systemic tumor necrosis factor (TNF) alpha expression, and oxidative stress parameters. Materials and methods: Eighty rats were equally divided into 10 groups. Four dental adhesives (Clearfil SE Bond, iBond, Clearfil Protect Bond, and Adper Prompt L-Pop) were applied to connective tissue of the rats. In the control group, rats were operated on with no material being applied. Biocompatibilities of the bonding agents were evaluated according to tissue responses, histopathologic and biochemical TNF-alpha expressions, and levels of malondialdehyde, glutathione, superoxide dismutase and glutathione peroxidase activities 1 week and 1 month after initiation of treatment. Results: All neutrophil levels and edema formation between the iBond group and the other groups were statistically significant after 1 week. Fibroblast levels in the Clearfil SE Bond group were higher than all other groups. Vascularization levels statistically differed between the Clearfil SE Bond and iBond groups, and between the Adper Prompt L-Pop and control groups. Tissue TNF-alpha levels statistically differed in all groups other than the control group. At the end of 1 month, the neutrophil level in the iBond group was higher than that in the control group. The differences in fibroblast levels after 1 month were statistically significant between the Clearfil SE Bond and Clearfil Protect Bond groups, and between the control and iBond groups. Tissue TNF-alpha levels were higher in the iBond, Clearfil Protect Bond, and Adper Prompt L-Pop groups than in the Clearfil SE Bond and control groups. Conclusion: There were no statistical differences in levels of serum TNF-alpha and oxidative stress parameters in any groups during the course of the study. The four different adhesive systems exhibited different degrees of local toxicity to the subsurface of the skin of rats, but no systemic toxicity was detected.Ataturk University Scientific Project Research Foundation, TurkeyAtaturk University [2003166]; Heraeus Kulzer GmbH; Dental Department of Kuraray America, IncThis study was supported by a grant-in-aid (2003166) from the Ataturk University Scientific Project Research Foundation, Turkey. The iBond and Clearfil Protect Bond used in this study was generously supplied by Heraeus Kulzer GmbH and the Dental Department of Kuraray America, Inc. We thank Dr Yunus Emre Ozkanlar for critically reviewing the manuscript

Lichenoid Drug Eruption Associated With Imatinib Mesylate: Two Cases

Imatinib mesylate (STI571) is a new therapeutic agent which inhibits the tyrosine kinase of the BCR-ABL, c-kit and platelet derived growth factor oncogenes. It is used for the treatment of chronic myelogenous leukemia, Philadelphia chromosome positive acute lymphoblastic leukemia and gastrointestinal stromal tumors. Although, cutaneous side effects of this drug is common, lichenoid eruption is exceptional. We report two cases of disseminated lichenoid cutaneous reaction, which developed in two patients with chronic myelogenous leukemia treated with imatinib mesylate

The crucial role of pathologist in determining the prognosis of colorectal carcinoma cases: An analysis of 502 cases with colorectal carcinoma by Turkish National Working Group of Gastrointestinal Pathology

WOS: 000249454600179

Efficacy of L-Carnitine Administration on Lungs of Neonatal Rats Exposed to Hyperoxia

Oxygen toxicity is believed to play a prominent role in the lung injury that leads to the development of bonchopulmonary dysplasia. L-carnitine (LCAR) is an antioxidant and prevents the accumulation of end products of lipid peroxidation, acts as a free radical scavenger and protects cells from reactive oxygen species. The aim of the present study was to evaluate the effects of LCAR on the histopathologic characteristics of oxygen-induced lung injury. Thirty one rat pups were divided into 4 groups: Healthy control group (group 1, n = 8), hyperoxia-exposed group (group 2, n = 7), hyperoxia-exposed and 100 mg kg(-1) LCAR-treated group (goup 3, n = 10), hyperoxia-exposed and 200 mg kg(-1) LCAR-treated group (goup 4, n = 6). Although in group given 100 mg kg(-1) LCAR together with hyperoxia-exposure, it was observed some improvement, histopathologic findings obtained from animals treated with 200 mg kg(-1) LCAR were similar to normal surprisingly. In conclusion, it should be focused on more the possible protective effect mechanism of LCAR and it should be made more effort to be able to use it in routine